Calf venous compliance measured by venous occlusion plethysmography: methodological aspects

Skoog, Johan; Zachrisson, Helene; Lindenberger, Marcus; Ekman, Mikael; Ewerman, Lea; Länne, Toste

doi:10.1007/s00421-014-3009-4

Cited by 17 publications

(23 citation statements)

References 41 publications

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“…We recently investigated the impact of net fluid filtration on C calf calculated with the QRE and found that some of the subjects displayed a nonphysiological negative C calf in the high pressure range (44). Accordingly, the present study revealed that 10% of the subjects at 55 mmHg and ϳ75% of the subjects at 60 mmHg displayed a negative C calf calculated with the QRE.…”

Section: Vwm Vs Qrementioning

confidence: 78%

“…1B). The calf cuff pressure-venous pressure relationship is less reliable below 10 mmHg, and these data were excluded from the analysis (44). All data were recorded, stored, and analyzed using PeriVasc software (Ekman Biomedical Data, Göteborg, Sweden).…”

Section: Venous Occlusion Plethysmographymentioning

confidence: 99%

“…Elevation of cuff pressure to 60 mmHg evoked a rapid increase in calf volume to the maximum volume stored in the veins at the given pressure (V cap response), followed by a slower increase caused by net fluid filtration. We recently showed that V cap is completed within 3-4 min when cuff pressure is elevated to 60 mmHg (44). Net fluid filtration (ml·100 ml Ϫ1 ·min Ϫ1 ) was therefore calculated as the slope of the volume curve between 4 and 8 min, and V cap (ml/100 ml) was obtained by a backward extrapolation of the filtration slope to the onset of venous occlusion plethysmography (VOP) (29).…”

Section: Venous Occlusion Plethysmographymentioning

confidence: 99%

“…In these studies, venous compliance was determined after several minutes of venous stasis without separation of venous blood pooling from the prominent net fluid filtration. We recently demonstrated that this can lead to misinterpretations, since net fluid filtration significantly affects venous compliance (44). Present assessments commonly use a mathematically derived quadratic regression equation (QRE) to model the venous pressure-volume curve and the first derivative of this equation to characterize venous compliance.…”

mentioning

confidence: 99%

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Reduced venous compliance: an important determinant for orthostatic intolerance in women with vasovagal syncope

Skoog

Lindenberger

Ekman³

et al. 2016

American Journal of Physiology-Regulatory, Integrative and Comp

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The influence of lower limb venous compliance on orthostatic vasovagal syncope (VVS) is uncertain. The most widespread technique to calculate venous compliance uses a nonphysiological quadratic regression equation. Our aim was therefore to construct a physiologically derived venous wall model (VWM) for calculation of calf venous compliance and to determine the effect of venous compliance on tolerance to maximal lower body negative pressure (LBNP). Venous occlusion plethysmography was used to study calf volume changes in 15 women with VVS (25.5 ± 1.3 yr of age) and 15 controls (22.8 ± 0.8 yr of age). The fit of the VWM and the regression equation to the experimentally induced pressure-volume curve was examined. Venous compliance was calculated as the derivative of the modeled pressure-volume relationship. Graded LBNP to presyncope was used to determine the LBNP tolerance index (LTI). The VWM displayed a better fit to the experimentally induced pressure-volume curve (P < 0.0001). Calf blood pooling was similar in the groups and was not correlated to the LTI (r = 0.204, P = 0.30). Venous compliance was significantly reduced at low venous pressures in women with VVS (P = 0.042) and correlated to the LTI (r = 0.459, P = 0.014) in the low pressure range. No correlation was found between venous compliance at high venous pressures and the LTI. In conclusion, the new VWM accurately adopted the curvilinear pressure-volume curve, providing a valid characterization of venous compliance. Reduced venous compliance at low venous pressures may adversely affect mobilization of peripheral venous blood to the central circulation during hypovolemic circulatory stress in women with VVS.

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Section: Vwm Vs Qrementioning

confidence: 78%

Section: Venous Occlusion Plethysmographymentioning

confidence: 99%

Section: Venous Occlusion Plethysmographymentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Reduced venous compliance: an important determinant for orthostatic intolerance in women with vasovagal syncope

Skoog

Lindenberger

Ekman³

et al. 2016

American Journal of Physiology-Regulatory, Integrative and Comp

Self Cite

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show abstract

“…The flow was measured at 3 sec ‐cuff inflation to remove variabilities in the measurement of blood flow without the influence of changes in capillary filtration and venous compliance (Skoog et al. ).…”

Section: Methodsmentioning

confidence: 99%

Microvascular function in pre-eclampsia is influenced by insulin resistance and an imbalance of angiogenic mediators

et al. 2017

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In preeclampsia, maternal microvascular function is disrupted and angiogenesis is dysfunctional. Insulin resistance that occurs in some pregnancies also pathologically affects microvascular function. We wished to examine the relationship of angiogenic mediators and insulin resistance on microvascular health in pregnancy. We performed a nested, case–control study of 16 women who developed preeclampsia with 17 normal pregnant controls. We hypothesized that the impaired microvascular blood flow in preeclamptic women associated with an increased ratio of the antiangiogenic factors; (s‐endoglin [sEng] and soluble fms‐like tyrosine kinase‐1 [sFlt‐1]) and proangiogenic molecule (placental growth factor [PlGF]) could be influenced by insulin resistance. Serum samples taken after 28 weeks of gestation were measured for the angiogenic factors, insulin, and glucose alongside the inflammatory marker; tumor necrosis factor‐α and endothelial activation, namely; soluble vascular cell adhesion molecule 1, intercellular adhesion molecule‐1, and e‐selectin. Maternal microvascular blood flow, measured by strain gauge plethysmography, correlated with ratios of pro‐ and antiangiogenic mediators independently of preeclampsia. Decreased microvascular function measured in preeclampsia strongly correlated with both the antiangiogenic factor (sFlt‐1 + sEng): PlGF ratio and high levels of insulin resistance, and combining insulin resistance with antiangiogenic factor ratios further strengthened this relationship. In pregnancy, microvascular blood flow is strongly associated with perturbations in pro‐ and antiangiogenic mediators. In preeclampsia, the relationship of maternal microvascular dysfunction with antiangiogenic mediators is strengthened when combined with insulin resistance.

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Vascular Parameters for Ambulatory Monitoring of Congestive Heart Failure Patients: Proof of Concept

Goy

Yanicelli

Vargas

et al. 2019

Cardiovasc Eng Tech

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Calf venous compliance measured by venous occlusion plethysmography: methodological aspects

Cited by 17 publications

References 41 publications

Reduced venous compliance: an important determinant for orthostatic intolerance in women with vasovagal syncope

Reduced venous compliance: an important determinant for orthostatic intolerance in women with vasovagal syncope

Microvascular function in pre-eclampsia is influenced by insulin resistance and an imbalance of angiogenic mediators

Vascular Parameters for Ambulatory Monitoring of Congestive Heart Failure Patients: Proof of Concept

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