Calibrated magnetic resonance hydrometry to quantify pancreatic juice: A preliminary study

Abstract

Purpose:To investigate the effectiveness of the calibrated MR hydrometry (CMRH) method for accurately measuring pancreatic secretion. Materials and Methods:All studies were performed on a 1.5-T MR system using a fat-suppressed, single-shot halfFourier fast spin-echo sequence with a standard body coil. A certain volume (20 mL) of saline solution was employed as an extrabody calibrator. The validity of the CMRH method was tested both in vitro and in vivo, and actual and calculated volumes were compared. Results:The in vitro study yielded a high correlation (r ϭ 0.99; P Ͻ 0.0001) between the actual volume of saline solution in the imaging field and the calculated volume. In the in vivo study, for all volunteers, there was a very strong and significant positive correlation between the measured signal intensities or calculated volumes and actual volumes (correlation coefficient range: 0.94 -0.99; P Ͻ 0.0001).Conclusion: This preliminary study shows that CMRH is an effective tool to measure the amount of pancreatic fluid secretion.

MRI and S‐MRCP findings in patients with suspected chronic pancreatitis: Correlation with endoscopic pancreatic function testing (ePFT)

“…Secretin stimulated endoscopic pancreatic function testing (ePFT) is considered one of the most sensitive clinical pancreatic exocrine function testing methods (1–3). Secretin stimulated magnetic resonance cholangiopancreatography (S‐MRCP) can estimate pancreatic exocrine function, and at the same time an increased number of side branch ectasia and or decreased pancreatic duct compliance after secretin stimulation can be demonstrated as early imaging findings of chronic pancreatitis (4–7). In addition, there have been studies that compared pancreatic exocrine function and pancreatic parenchymal and ductal findings on magnetic resonance imaging (MRI), MRCP, ERCP, and endoscopic ultrasound (EUS).…”