Abstract. Estimating the flow velocity and discharge in rivers is of particular interest for monitoring, modelling, and research purposes. Instruments for measuring water level and surface velocity are generally mounted on bridge decks, and this poses a challenge because the bridge structure (e.g., piers and abutments) can lead to perturbated flow fields. The current research aims to investigate the applicability of the entropy theory to estimate the velocity distribution and the discharge in the vicinity of river bridges. To this purpose, a Computational Fluid Dynamics (CFD) model is used to obtain three-dimensional flow fields along a stretch of the Paglia River (central Italy), where a historical multi-arch bridge strongly affects flood flows. The input data for the entropy model include the cross-sectional bathymetry and the surface velocity provided by the numerical simulations. Different flow conditions and cross-sections, either upstream and downstream of the bridge, are considered. It is found that the entropy model can be applied safely upstream of the bridge, also when forced with a single (i.e., the maximum) value of the surface velocity, with errors on total discharge below 13 % in the considered case. On the contrary, downstream the bridge, the wakes generated by the bridge piers strongly affect the velocity distribution, both in the spanwise and in the vertical directions, and for very long distances. Here, notwithstanding the complex and multimodal spanwise distribution of flow velocity, the entropy model estimates the discharge with error lower than 8 % if forced with the river-wide distribution of the surface velocity. The present study has important implications for the optimal positioning of sensors and suggest the potential of using CFD modelling and entropy theory jointly to foster the knowledge of river systems.