Calicheamicin−Homeodomain Conjugate as an Efficient, Sequence-Specific DNA Cleavage and Mapping Tool

Wu, Minwan; Stoermer, Doris; Tullius, and Thomas D.; Townsend, Craig A.

doi:10.1021/ja002280o

Cited by 14 publications

(11 citation statements)

References 16 publications

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“…Binucleating ligands are particularly suited for the synthesis of such complexes as they are more stable and the Gd(III) and Cu(II) metal ions are fixed in close proximity, which has important implications for metal-metal interactions and their reactivity 7 . These properties have turned chemical nucleases into useful tools as adjuvant in PCR diagnostics 8 nucleic acid attacking and cleaving agents 9 .…”

Section: S208mentioning

confidence: 99%

Spectral, Magnetic, Electrochemical, Photochemical, DNA Binding and Cleavage, Catalytic and Biological Studies of 2, 2'-Bipyridyl Based d-f Hetero Binuclear Gd(III) and Cu(II) Complexes

2013

Chem Sci Trans

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Section: S208mentioning

confidence: 99%

Spectral, Magnetic, Electrochemical, Photochemical, DNA Binding and Cleavage, Catalytic and Biological Studies of 2, 2'-Bipyridyl Based d-f Hetero Binuclear Gd(III) and Cu(II) Complexes

2013

Chem Sci Trans

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“…The findings described above have been used to prepare DNA-cleaving calicheamicin-oligosaccharide conjugates. [51] For example, Danishefsky and co-workers have prepared a daunorubicin calicheamicin oligosaccharide hybrid. [52] Nicolaou et al designed and prepared calicheamicin q I 1, a fully synthetic analogue of 26, which was shown to be a potent and sequence-specific DNA scissor.…”

Section: Calicheamicin G Imentioning

confidence: 99%

Probing the Biology of Natural Products: Molecular Editing by Diverted Total Synthesis

2010

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The systematic modification of natural products through diverted total synthesis is a powerful concept for the systematic modification of natural products with the aim of studying mechanistic aspects of their biological activity. This concept offers far-reaching opportunities for discovery at the interface of biology and chemistry. It is underpinned by the power of chemical synthesis, which manifests itself in the ability to modify structure at will. Its implementation, when combined with innovative design, enables the preparation of unique mechanistic probes that can be decisive in differentiating and validating biological hypotheses at the molecular level. This Review assembles a collection of classic and current cases that illustrate and underscore the scientific possibilities for practitioners of chemical synthesis.

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“…Die oben beschriebenen Befunde wurden genutzt, um DNA spaltende Calicheamicin‐Oligosaccharid‐Konjugate herzustellen 51. Zum Beispiel synthetisierte Danishefskys Gruppe ein Daunorubicin‐Calicheamicin‐Oligosaccharid‐Hybrid 52.…”

Section: Calicheamicin γI1unclassified

Untersuchung der Biologie von Naturstoffen: systematische Strukturvariation durch umgelenkte Totalsynthese

Szpilman

Carreira

2010

Angewandte Chemie

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Calicheamicin−Homeodomain Conjugate as an Efficient, Sequence-Specific DNA Cleavage and Mapping Tool

Cited by 14 publications

References 16 publications

Spectral, Magnetic, Electrochemical, Photochemical, DNA Binding and Cleavage, Catalytic and Biological Studies of 2, 2'-Bipyridyl Based d-f Hetero Binuclear Gd(III) and Cu(II) Complexes

Spectral, Magnetic, Electrochemical, Photochemical, DNA Binding and Cleavage, Catalytic and Biological Studies of 2, 2'-Bipyridyl Based d-f Hetero Binuclear Gd(III) and Cu(II) Complexes

Probing the Biology of Natural Products: Molecular Editing by Diverted Total Synthesis

Untersuchung der Biologie von Naturstoffen: systematische Strukturvariation durch umgelenkte Totalsynthese

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