Calidad de vida y estados crónicos de salud en supervivientes de leucemia aguda infantil

Aznar, Elena Guadalupe Corella; Ayerza-Casas, Ariadna; Bañeres, Ana Carboné; Escribano, María Ángeles Carlota Calvo; Aizpún, José Ignacio Labarta; Villagrasa, Pilar Samper

doi:10.1016/j.medcli.2018.05.014

Cited by 6 publications

(2 citation statements)

References 28 publications

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“…The wide range of recovery time and age at testing among our patients may also affect our findings, as different developmental levels during treatment and at testing may influence this psychophysical assessment (Hirschfeld et al 2012 ; Blankenburg et al 2011 ). QoL may have given more insights into the clinical relevance of our study (Vetsch et al 2018 ; Corella Aznar et al 2019 ; Ness et al 2015 ; Goebel et al 2019 ), but was not measured due to already extensive testing. In future studies, large- and small-fiber neuropathy leading to motor function impairment could be tested by, e.g., 6-min walking test, and timed up-and-go test (Varedi et al 2018b ).…”

Section: Discussionmentioning

confidence: 99%

Long-term small-fiber neuropathy and pain sensitization in survivors of pediatric acute lymphoblastic leukemia after stem cell transplantation

Ruscher

Lieber

Kühl

et al. 2020

J Cancer Res Clin Oncol

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Purpose We aimed at describing for the first time peripheral small-fiber neurotoxicity and pain sensitization in survivors of pediatric acute lymphoblastic leukemia after stem cell transplantation (SCT). Methods In a cross-sectional, retrospective, single-center study, we assessed 25 relapse-free long-term survivors (median age at SCT: 11 ± 4.9 years; median time between SCT and testing: 8.25 years, 19 males) using a reduced version of the pediatric-modified total neuropathy score for clinical assessment and Quantitative Sensory Testing (QST). Inclusion criteria: $$\ge$$ ≥ 6 years old at testing, $$\le$$ ≤ 18 years old at time of SCT, $$\ge$$ ≥ 1 year between SCT and testing. Results Nine patients (36%) had peripheral neuropathy as defined by the clinical red-pmTNS (≥ 4). The QST parameters mechanical pain sensitivity, mechanical detection threshold, thermal sensory limen, vibration detection threshold and pressure pain threshold were significantly abnormal in the survivor cohort (p < 0.0038). Except for one, all survivors showed at least one abnormal QST parameter. When using QST, signs of small and large fiber dysfunction were present in 22 (88%) and 17 (68%) survivors, respectively. More than half of all survivors were found to experience pathologic sensitization to pain. Conclusions and implications for cancer survivors Survivors of pediatric acute lymphoblastic leukemia after SCT are at high risk for long-term peripheral neuropathy with a dominating small-fiber and pain sensitization pattern.

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Section: Discussionmentioning

confidence: 99%

Long-term small-fiber neuropathy and pain sensitization in survivors of pediatric acute lymphoblastic leukemia after stem cell transplantation

Ruscher

Lieber

Kühl

et al. 2020

J Cancer Res Clin Oncol

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“…In this regard, the vibrational frequency calculations were performed for the entire dataset and displayed no imaginary frequency, indicating that all of the geometries were minimum-geometry structures. Both minimum structures and frequency calculations were used to find electronic and molecular descriptors such as dipolar momentum (µ), HOMO (High Occupied Molecular Orbital) and LUMO (Low Unoccupied Molecular Orbital) energies, polarizability (α), enthalpy (H), entropy (S), free energy (G), ionization potential (PI), electronic affinity energy (EAE), hardness (η), softness (s), electrophilic index (ω), lipophilia (ClogP), polar surface area (PSA), topological index (TI), Balaban index (BI), hydrogen bond acceptor (HA), hydrogen bond donator (HD), AC [1]_K_F_AB_nCi_2_M1_NS0_C_LGL [8][9]_a_MID (AC1RABABMID), and TS [1]_K_F_AB_nCi_2_M1_SS0_T_LGL [2][3]_a_MID (TS1KFABMID). Except for AC1RABABMID and TS1KFABMID, these topological indexes were computed using Chemaxon [50], while AC1RABABMID and TS1KFABMID were calculated using QuBiLs-MIDAS as reported previously [51].…”

Section: Molecular Modelingmentioning

confidence: 99%

Modeling the Antileukemia Activity of Ellipticine-Related Compounds: QSAR and Molecular Docking Study

et al. 2019

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The antileukemia cancer activity of organic compounds analogous to ellipticine representes a critical endpoint in the understanding of this dramatic disease. A molecular modeling simulation on a dataset of 23 compounds, all of which comply with Lipinski’s rules and have a structure analogous to ellipticine, was performed using the quantitative structure activity relationship (QSAR) technique, followed by a detailed docking study on three different proteins significantly involved in this disease (PDB IDs: SYK, PI3K and BTK). As a result, a model with only four descriptors (HOMO, softness, AC1RABAMBID, and TS1KFABMID) was found to be robust enough for prediction of the antileukemia activity of the compounds studied in this work, with an R2 of 0.899 and Q2 of 0.730. A favorable interaction between the compounds and their target proteins was found in all cases; in particular, compounds 9 and 22 showed high activity and binding free energy values of around −10 kcal/mol. Theses compounds were evaluated in detail based on their molecular structure, and some modifications are suggested herein to enhance their biological activity. In particular, compounds 22_1, 22_2, 9_1, and 9_2 are indicated as possible new, potent ellipticine derivatives to be synthesized and biologically tested.

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Quality of life of adolescent and adult survivors of childhood cancer in Europe—A systematic review

Larsen

Amidi

Ghith

et al. 2023

Intl Journal of Cancer

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Advances in diagnostics and treatment of childhood cancer during the past few decades have substantially increased survival, resulting in a growing population of survivors of childhood cancer. Somatic and mental late effects of the cancer and the treatment may impact the quality of life (QoL). Previous reviews of QoL in survivors of childhood cancer have shown contradictory findings across studies and the majority of studies included have been based on data from North America and may not be directly comparable to a European setting. The aim of our study was to critically evaluate and summarise the latest evidence on the QoL of childhood cancer survivors in Europe and to identify survivors at particular risk. The eligible studies were published between 2008 and 2022, conducted in Europe and included participants who had survived at least 5 years after diagnosis of a childhood cancer. The main outcome of interest was QoL of survivors which was measured with validated qualitative and quantitative QoL questionnaires. A systematic literature search conducted in PubMed, EMBASE, PsycINFO and CINALH resulted in inclusion of 36 articles with a total of 14 342 survivors of childhood cancer. The majority of included studies found that childhood cancer survivors reported poorer QoL than comparisons. Female gender, treatment with haematopoietic stem cell transplantation and a brain tumour diagnosis were associated with lower QoL. With a growing population of childhood cancer survivors with many years ahead of them, targeted interventions and optimal follow‐up care are important to improve the QoL of survivors.

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Calidad de vida y estados crónicos de salud en supervivientes de leucemia aguda infantil

Cited by 6 publications

References 28 publications

Long-term small-fiber neuropathy and pain sensitization in survivors of pediatric acute lymphoblastic leukemia after stem cell transplantation

Long-term small-fiber neuropathy and pain sensitization in survivors of pediatric acute lymphoblastic leukemia after stem cell transplantation

Modeling the Antileukemia Activity of Ellipticine-Related Compounds: QSAR and Molecular Docking Study

Quality of life of adolescent and adult survivors of childhood cancer in Europe—A systematic review

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