The U.S. Department of Energy (DOE) Office of Fossil Energy (FE) National Energy Technology Laboratory (NETL) Carbon Storage Program helps develop technologies that safely and permanently store carbon dioxide (CO2) without adversely impacting natural resources or hindering economic growth. Since 1997, the program has significantly advanced carbon capture, utilization, and storage (CCUS) science and technology, with more than 10.5 million metric tons (MMT) of CO2 safely stored. However, key gaps in experience and knowledge This article is protected by copyright. All rights reserved. This is the author manuscript accepted for publication and has undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1002/aic.16855 remain (e.g., the technology, expertise, and processes needed to safely characterize and monitor 50+ MMT-scale geologic CO2 storage sites). DOE's Carbon Storage Assurance Facility Enterprise (CarbonSAFE) Initiative (launched in FY16) is beginning to address this gap. The CarbonSAFE Initiative currently consists of 13 projects in Phase I: Integrated Carbon Capture and Storage (CCS) Pre-Feasibility and 6 projects in Phase II: Storage Complex Feasibility. This paper includes the latest updates from the CarbonSAFE Initiative.