California Men's Health Study (CMHS): a multiethnic cohort in a managed care setting

Enger, Shelley M.; Eeden, Stephen K. Van Den; Sternfeld, Barbara; Loo, Ronald K.; Quesenberry, Charles P.; Rowell, Sarah; Sadler, Marianne; Schaffer, Donna; Habel, Laurel A.; Caan, Bette J.

doi:10.1186/1471-2458-6-172

Cited by 55 publications

(52 citation statements)

References 24 publications

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“…Furthermore, the characteristics of the CMHS cohort was similar to the general male population who participated in a random digit dial survey in California. 29 Therefore, our results are likely generalizable to the broader male population in similar age range.…”

Section: Epidemiologymentioning

confidence: 91%

“…A total of 84,170 men including a nearly 40% minority participation completed the questionnaires and hence joined the cohort. Details of the cohort design and recruitment methods were described previously by Enger et al 29 Between study baseline and December 2007, 14,177 men in the cohort terminated their health plan membership (not including death), resulting in a follow-up rate of 83% by end of 2007.…”

mentioning

confidence: 99%

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Red wine consumption and risk of prostate cancer: The California Men's Health Study

Chao

Haque

Eeden

et al. 2009

Intl Journal of Cancer

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Red wine contains polyphenol antioxidants that inhibit prostate cancer development in animal studies. We investigated the effect of red wine intake on the risk of prostate cancer using data prospectively collected in the California Men's Health Study (CMHS). CMHS is a multiethnic cohort of 84,170 men aged 45-69 years who were members of the Kaiser Permanente Southern and Northern California Health Plans. Information on demographic and lifestyle factors was collected using mailed questionnaires between 2002 and 2003. We used Cox models to estimate the effect of red wine on prostate cancer risk, adjusting for potential confounders. A total of 1,340 incident prostate cancer cases identified from Surveillance, Epidemiology and End Result-affiliated cancer registries were included in the analyses. We did not find a clear association between red wine intake and risk of prostate cancer. Hazard ratio (HR) estimates for consuming <1 drink/week, 1 drink/week but <1 drink/day and 1 drink/day were 0.89, 95% confidence interval (0.74-1.07), 0.99 (0.83-1.17) and 0.88 (0.70-1.12), respectively. Further, we observed no linear dose response. The lack of association for red wine intake was consistently observed when we restricted the analyses to those with and without a history of PSA screening. In addition, we also did not observe any association with prostate cancer for beer, white wine, liquor or combined alcoholic beverage intake (HR for combined alcoholic beverage intake of 5 drinks/day 5 1.16 (0.83-1.63). Neither red wine nor total alcohol consumption were associated with prostate cancer risk in this population of moderate drinkers.Red wine is a rich source of polyphenol antioxidants such as resveratrol. Recently, resveratrol has received considerable attention because of its potent anti-cancer properties.

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Section: Epidemiologymentioning

confidence: 91%

mentioning

confidence: 99%

Red wine consumption and risk of prostate cancer: The California Men's Health Study

Chao

Haque

Eeden

et al. 2009

Intl Journal of Cancer

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“…Some studies have reported diabetic men to be screened less often (23,47), whereas others have noted no difference or increased screening in some age groups (22). We examined two interval cohorts within our setting (48,49) and found little evidence of differential PSA screening by diabetes mellitus.…”

Section: Discussionmentioning

confidence: 99%

Glycemic Status and Risk of Prostate Cancer

Darbinian

Ferrara

Eeden

et al. 2008

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: To examine the risk of prostate cancer and glucose tolerance in a large, racially diverse cohort. Methods: We conducted a cohort study of 47,209 male members of Kaiser Permanente Northern California who had completed at least one Multiphasic Health Checkup (MHC) between 1964 and 1973. The MHC provided information on diabetes, serum glucose 1 h after a 75-g oral glucose challenge test, demographics, and other health conditions. Cox proportional hazards were used to estimate relative risks (RR) while adjusting for confounders. Results: During a median follow-up of 18.4 years, a total of 2,833 men developed prostate cancer. At baseline, 4.6% (n = 2,159) of the cohort had diabetes and 33% had serum glucose of z200 mg/dL. After adjusting for age, race, birth year, and body mass index, RR (95% confidence interval) of prostate cancer

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“…A total of 84,170 men including a nearly 40% minority participation completed the questionnaires and hence joined the cohort. Details of the cohort design and recruitment methods were described previously by Enger et al (10). The CMHS cohort was similar to the population of health plan members on important characteristics and appeared similar to men who responded to a general health survey in California (California Health Interview Survey) on a variety of important demographic and clinical characteristics (10).…”

Section: Methodsmentioning

confidence: 99%

“…Details of the cohort design and recruitment methods were described previously by Enger et al (10). The CMHS cohort was similar to the population of health plan members on important characteristics and appeared similar to men who responded to a general health survey in California (California Health Interview Survey) on a variety of important demographic and clinical characteristics (10). Between study baseline and December 2006, 11,144 men in the cohort terminated their health plan membership, resulting in a follow-up rate of 87% by end of the 2006.…”

Section: Methodsmentioning

confidence: 99%

Alcoholic Beverage Intake and Risk of Lung Cancer: The California Men's Health Study

Chao

Slezak²,

Caan³

et al. 2008

Cancer Epidemiology, Biomarkers &Amp; Prevention

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We investigated the effect of alcoholic beverage consumption on the risk of lung cancer using the California Men's Health Study. Methods: The California Men's Health Study is a multiethnic cohort of 84,170 men ages 45 to 69 years who are members of the Kaiser Permanente California health plans. Demographics and detailed lifestyle characteristics were collected from surveys mailed between 2000 and 2003. Incident lung cancer cases were identified by health plan cancer registries through December 2006 (n = 210). Multivariable Cox's regression was used to examine the effects of beer, red wine, white wine (including rosé), and liquor consumption on risk of lung cancer adjusting for age, race/ethnicity, education, income, body mass index, history of chronic obstructive pulmonary disease/emphysema, and smoking history.Results: There was a significant linear decrease in risk of lung cancer associated with consumption of red wine among ever-smokers: hazard ratio (HR), 0.98; 95% confidence interval (95% CI), 0.96-1.00 for increase of 1 drink per month. This relationship was slightly stronger among heavy smokers (z20 pack-years): HR, 0.96; 95% CI, 0.93-1.00. When alcoholic beverage consumption was examined by frequency of intake, consumption of z1 drink of red wine per day was associated with an approximately 60% reduced lung cancer risk in ever-smokers: HR, 0.39; 95% CI, 0.14-1.08. No clear associations with lung cancer were seen for intake of white wine, beer, or liquor. Conclusion: Moderate red wine consumption was inversely associated with lung cancer risk after adjusting for confounders. Our results should not be extrapolated to heavy alcohol consumption. (Cancer Epidemiol Biomarkers Prev 2008;17(10):2692 -9)

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California Men's Health Study (CMHS): a multiethnic cohort in a managed care setting

Abstract: Background: We established a male, multiethnic cohort primarily to study prostate cancer etiology and secondarily to study the etiologies of other cancer and non-cancer conditions.

Cited by 55 publications

References 24 publications

Red wine consumption and risk of prostate cancer: The California Men's Health Study

Red wine consumption and risk of prostate cancer: The California Men's Health Study

Glycemic Status and Risk of Prostate Cancer

Alcoholic Beverage Intake and Risk of Lung Cancer: The California Men's Health Study

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