Californium-252 interstitial implants in carcinoma of the tongue

Vtyurin, B. M.; Ivanov, Vladimir N.; Medvedev, V. S.; Galantseva, G.F.; Abdulkadyrov, Said A.; Ivanova, Lyudmila F.; Petrovskaya, Galina A.; Plichko, V. I.

doi:10.1016/0360-3016(85)90173-7

Cited by 7 publications

(1 citation statement)

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“…In the 1980s, 252 Cf was used extensively in Russia for clinical applications in the high-and low-dose-rate regimens (16)(17)(18). To support Russian clinical implementation of high-dose-rate 252 Cf brachytherapy (19)(20)(21)(22) …”

Section: Empirical Modelmentioning

confidence: 99%

A Radiobiological Model for the Relative Biological Effectiveness of High-Dose-Rate²⁵²Cf Brachytherapy

et al. 2005

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While there is significant clinical experience using both low- and high-dose-rate 252Cf brachytherapy, there are minimal data regarding values for the neutron relative biological effectiveness (RBE) with both modalities. The aim of this research was to derive a radiobiological model for 252Cf neutron RBE and to compare these results with neutron RBE values used clinically in Russia. The linear-quadratic (LQ) model was used as the basis to characterize cell survival after irradiation, with identical cell killing rates (S(N) = S(gamma)) between 252Cf neutrons and photons used for derivation of RBE. Using this equality, a relationship among neutron dose and LQ radiobiological parameter (i.e., alpha(N), beta(N), alpha(gamma), beta(gamma)) was obtained without the need to specify the photon dose. These results were used to derive the 252Cf neutron RBE, which was then compared with Russian neutron RBE values. The 252Cf neutron RBE was determined after incorporating the LQ radiobiological parameters obtained from cell survival studies with fast neutrons and teletherapy photons. For single-fraction high-dose-rate neutron doses of 0.5, 1.0, 1.5 and 2.0 Gy, the total biologically equivalent doses were 1.8, 3.4, 4.7 and 6.0 RBE Gy with 252Cf neutron RBE values of 3.2, 2.9, 2.7 and 2.5, respectively. Using clinical data for late-responding reactions from 252Cf, Russian investigators created an empirical model that predicted high-dose-rate 252Cf neutron RBE values ranging from 3.6 to 2.9 for similar doses and fractionation schemes and observed that 252Cf neutron RBE increases with the number of treatment fractions. Using these relationships, our results were in general concordance with high-dose-rate 252Cf RBE values obtained from Russian clinical experience.

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Section: Empirical Modelmentioning

confidence: 99%

A Radiobiological Model for the Relative Biological Effectiveness of High-Dose-Rate²⁵²Cf Brachytherapy

et al. 2005

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Salvagebehandlung fortgeschrittener Plattenepithelkarzinome der Mundhöhle und des Oropharynx

Krüll

Schwarz

et al. 1997

Strahlenther. Onkol.

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Californium-252 (252Cf) versus Conventional Gamma Radiation in the Brachytherapy of Advanced Cervical Carcinoma

2003

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Californium-252 interstitial implants in carcinoma of the tongue

Cited by 7 publications

References 20 publications

A Radiobiological Model for the Relative Biological Effectiveness of High-Dose-Rate²⁵²Cf Brachytherapy

A Radiobiological Model for the Relative Biological Effectiveness of High-Dose-Rate²⁵²Cf Brachytherapy

Salvagebehandlung fortgeschrittener Plattenepithelkarzinome der Mundhöhle und des Oropharynx

Californium-252 (252Cf) versus Conventional Gamma Radiation in the Brachytherapy of Advanced Cervical Carcinoma

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Californium-252 interstitial implants in carcinoma of the tongue

Cited by 7 publications

References 20 publications

A Radiobiological Model for the Relative Biological Effectiveness of High-Dose-Rate252Cf Brachytherapy

A Radiobiological Model for the Relative Biological Effectiveness of High-Dose-Rate252Cf Brachytherapy

Salvagebehandlung fortgeschrittener Plattenepithelkarzinome der Mundhöhle und des Oropharynx

Californium-252 (252Cf) versus Conventional Gamma Radiation in the Brachytherapy of Advanced Cervical Carcinoma

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Product

Resources

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A Radiobiological Model for the Relative Biological Effectiveness of High-Dose-Rate²⁵²Cf Brachytherapy

A Radiobiological Model for the Relative Biological Effectiveness of High-Dose-Rate²⁵²Cf Brachytherapy