calix[4]arene C-145 Effects on Plasma Haemostasis

DS, Chernyshenko VO Korolova; Pashevin, Dosenko VAA; LV, Kalchenko VI Pirogova

doi:10.4172/2153-2435.1000406

Pharm Anal Acta

2015

DOI: 10.4172/2153-2435.1000406

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calix[4]arene C-145 Effects on Plasma Haemostasis

Chernyshenko VO Korolova DS¹,

Dosenko VAA Pashevin²,

Kalchenko VI Pirogova LV³

Abstract: Methods: Parameters of coagulation system of rabbits intravenously injected with C-145 were monitored. We measured thrombin time (TT), ecamulin time (ET) and activated partial thromboplastin time (APTT), determined the levels of fibrinogen, prothrombin, protein C, PAI-1, monitored overall haemostatic potential before and after the injection.Results: C-145 was administrated intravenously in the dose of 7.5 mg/kg of rabbit weight. 4 hours after the injection the thrombin time and activated partial thromboplastin… Show more

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Cited by 3 publications

References 17 publications

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Silica Nanoparticles Effects on Blood Coagulation Proteins and Platelets

Gryshchuk

Галаган

2016

Biochemistry Research International

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Interaction of nanoparticles with the blood coagulation is important prior to their using as the drug carriers or therapeutic agents. The aim of present work was studying of the primary effects of silica nanoparticles (SiNPs) on haemostasis in vitro. We studied the effect of SiNPs on blood coagulation directly estimating the activation of prothrombin and factor X and to verify any possible effect of SiNPs on human platelets. It was shown that SiNPs shortened coagulation time in APTT and PT tests and increased the activation of factor X induced by RVV possibly due to the sorption of intrinsic pathway factors on their surface. SiNPs inhibited the aggregation of platelet rich plasma induced by ADP but in the same time partially activated platelets as it was shown using flow cytometry. The possibility of SiNPs usage in nanomedicine is strongly dependant on their final concentration in bloodstream and the size of the particles that are used. However SiNPs are extremely promising as the haemostatic agents for preventing the blood loss after damage.

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Silica Nanoparticles Effects on Blood Coagulation Proteins and Platelets

Gryshchuk

Галаган

2016

Biochemistry Research International

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Approbation of Calix[4]arene as an Antithrombotic Agent in Vivo

Didkivskyi¹

2022

Biotechnol. acta

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Intravascular thrombosis is one of the main causes of mortality in the working-age population of the world. There are no antithrombotic drugs that act directly on the final stage of thrombosis – fibrin polymerization. However, a new compound of the calix[4]arene series, calix[4]arene C-145, which directly interacts with the fibrin polymerization site ‘A-knob’ thus blocking formation of polymeric fibrin and preventing thrombosis. So, the purpose of this work was to study the calix[4]arene C-145 series as antithrombotic agents in vivo using different animals and types of administration. Materials and methods. Laboratory animals (rats, mice and rabbits) were used for C-145 testing in vivo. Activated partial thromboplastin time and platelet aggregation were measured to determine the anticoagulant action after intravenous or per os administration. Results. Per os way of administration was selected as the optimal one. We showed the substantial prolongation of clotting time in APTT test that was observed starting from the 2nd hour after the per os administration, reached the maximum on 6th hour and eliminated in 24 hours. The effect of C-145 on platelets reached maximum on 4-6 hours and eliminated in 12 hours. Conclusions. C-145 was proven to be prospective antithrombotic drug that can be administered per os. Further investigations must be focused on the study of C-145 pharmacodynamics and metabolism. Such data would allow fast implementation of the tested compound into practice.

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Haemostasis modulation by calix[4]arene methylenebisphosphonic acid C-145 and its sulfur-containing analogue

Chernyshenko¹,

Savchuk²,

Cherenok³

et al. 2018

Ukr.Biochem.J

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calix[4]arene C-145 Effects on Plasma Haemostasis

Cited by 3 publications

References 17 publications

Silica Nanoparticles Effects on Blood Coagulation Proteins and Platelets

Silica Nanoparticles Effects on Blood Coagulation Proteins and Platelets

Approbation of Calix[4]arene as an Antithrombotic Agent in Vivo

Haemostasis modulation by calix[4]arene methylenebisphosphonic acid C-145 and its sulfur-containing analogue

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