Calixarene and Calixresorcarene Glycosides: Their Synthesis and Biological Applications

Synthesis and Properties of the Emerging Azacalix[14]arenes

“…[1-3] Many structural modifications [4,5] of the upper and lower rims (i.e., functionalization of the phenyl rings) in 1 have been performed and studied in terms of conformational flexibility and inclusion behavior. [6][7][8][9][10] In contrast, functionalization of the bridges cannot be achieved easily, [11] whereas new and specific properties can be envisaged.…”

Functionalized calix[4]arenes as potential therapeutic agents

“…One such macrocyclic scaffold is calixarene. [11][12][13][14][15][16][17][18][19][20] Calix [n]arenes are one of the most exciting synthetic macrocycles known to date besides cyclodextrins, crown ethers, cryptands, and cucurbiturils having diverse applications in supramolecular chemistry. [21][22][23] They can easily be synthesized by the reaction of p-tert-butyl phenol and formaldehyde in the presence of a base.…”

Simple Calix[n]arenes and Calix[4]resorcinarenes as Drug Solubilizing Agents

“…Such calix [n]arenes are often amphiphilic and may self-assemble into larger networks in an aqueous environment, sometimes an advantage for solubilization of small molecules [19]. Calix[n]arenes and calix [4]resorcinarenes with more complex functionalities that also have biological activity and potential for solubilization have been reported, glycosylated calix[n]arenes and other multivalent calix[n]arenes for example [20][21][22][23]. The structures of a calix [6]arene and a calix [8]arene.…”