Call for trials – Strategic criteria of clinical studies using physical plasma in head and neck cancer

Seebauer, Christian; Schuster, Matthias; Rutkowski, Rico; Mksoud, Maria; Nedrelow, David S.; Metelmann, Philine H.

doi:10.1016/j.cpme.2015.11.004

Cited by 9 publications

(3 citation statements)

References 6 publications

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“…This opens up new possibilities of supportive CAP application e.g. in surgical or radiative cancer eradication as well as in palliative cancer therapies (Metelmann et al 2015, Seebauer et al 2015.…”

Section: Medical Application Of Cold Atmospheric Plasmamentioning

confidence: 99%

Plasma medicine—current state of research and medical application

Weltmann¹,

Woedtke

2016

Plasma Phys. Control. Fusion

445

331

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Plasma medicine means the direct application of cold atmospheric plasma (CAP) on or in the human body for therapeutic purposes. Further, the field interacts strongly with results gained for biological decontamination. Experimental research as well as first practical application is realized using two basic principles of CAP sources: dielectric barrier discharges (DBD) and atmospheric pressure plasma jets (APPJ). Originating from the fundamental insights that the biological effects of CAP are most probably caused by changes of the liquid environment of cells, and are dominated by reactive oxygen and nitrogen species (ROS, RNS), basic mechanisms of biological plasma activity are identified. It was demonstrated that there is no increased risk of cold plasma application and, above all, there are no indications for genotoxic effects. The most important biological effects of cold atmospheric pressure plasma were identified: (1) inactivation of a broad spectrum of microorganisms including multidrug resistant ones; (2) stimulation of cell proliferation and tissue regeneration with lower plasma treatment intensity (treatment time); (3) inactivation of cells by initialization of programmed cell death (apoptosis) with higher plasma treatment intensity (treatment time). In recent years, the main focus of clinical applications was in the field of wound healing and treatment of infective skin diseases. First CAP sources are CE-certified as medical devices now which is the main precondition to start the introduction of plasma medicine into clinical reality. Plasma application in dentistry and, above all, CAP use for cancer treatment are becoming more and more important research fields in plasma medicine. A further in-depth knowledge of control and adaptation of plasma parameters and plasma geometries is needed to obtain suitable and reliable plasma sources for the different therapeutic indications and to open up new fields of medical application.

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Section: Medical Application Of Cold Atmospheric Plasmamentioning

confidence: 99%

Plasma medicine—current state of research and medical application

Weltmann¹,

Woedtke

2016

Plasma Phys. Control. Fusion

445

331

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“…Numerous in vitro and in vivo tests have unveiled the effectiveness of CAP not only in decontamination of infected wounds and the stimulation of wound healing, but the impact of CAP on cancer cellsas well [1,2,3]. As was recently mentioned by our group in a call for clinical trials [4], CAP is nearing the final stages of development for broad clinical applications in curative and palliative treatment of head and neck cancer. Despite a series of well observed clues that CAP might serve as a promising tool in cancer therapy, there are still many aspects that remain uncertain.…”

Section: Introductionmentioning

confidence: 88%

Clinical Studies Applying Physical Plasma in Head and Neck Cancer - Key Points and Study Design

Metelmann¹,

Nedrelow²,

Schuster³

et al. 2016

Int J Clin Res Trials

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“…At the current level of EBM, treatment with plasma will not be considered when surgery, radiotherapy, or chemotherapy is available and promising. Further clinical pilot studies should be choosing patients for palliation who face no positive effect of the first‐ to third‐line therapy . If the results of these pilot studies give way to curatively intended randomized clinical trials, it takes 5 years of follow‐up of the patients to obtain information about healing.…”

Section: Introductionmentioning

confidence: 99%

Treating cancer with cold physical plasma: On the way to evidence‐based medicine

Metelmann

Seebauer

Rutkowski

et al. 2018

Contributions to Plasma Physics

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The application of cold physical plasma in head and neck cancer patients is moving upwards in the pyramid of evidence‐based medicine (EBM). The effectiveness of plasma in cancer cell lines, cultivated human tumour cells, human tumour specimen freshly explanted from patients, animal model tumours, and animals with transplanted human tumour stem cells is well documented. There is consent among experts, referred to as EBM‐level IV, about the response to plasma in experimental settings and proof of concept by clinical pilot studies, EBM‐level III, for plasma treatment of head and neck cancer. If there is a manageable amount of tumour stem cells, like in precancerous lesions of oral mucosa or in small tumours like early basal cell carcinoma of the skin, plasma could become a clinical treatment option soon. Currently, it is already a concept in palliative care of patients with locally advanced head and neck cancer and contaminated ulcerations because of proven effectiveness against microbial pathogens. Patients greatly appreciate that plasma reduces strong fetid odour and pain while not being accompanied by serious side effects.

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Call for trials – Strategic criteria of clinical studies using physical plasma in head and neck cancer

Cited by 9 publications

References 6 publications

Plasma medicine—current state of research and medical application

Plasma medicine—current state of research and medical application

Clinical Studies Applying Physical Plasma in Head and Neck Cancer - Key Points and Study Design

Treating cancer with cold physical plasma: On the way to evidence‐based medicine

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