Calophyllum brasiliense Cambess: An alternative and promising source of shikimic acid

Marchiosi, Rogério; Ferro, Ana Paula; Ramos, Anderson Valdiney Gomes; Baldoqui, Débora Cristina; Constantin, Rodrigo Polimeni; Constantin, Renato Polimeni; Santos, Wanderley Dantas dos; Ferrarese-Filho, Osvaldo

doi:10.1016/j.scp.2019.100188

Cited by 5 publications

(4 citation statements)

References 35 publications

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“…The SHA pathway in plants is responsible for generating numerous secondary metabolites [42]. It plays an important role as an intermediary for the biosynthesis of aromatic amino acids (tryptophan, tyrosine, and phenylalanine) and has extensive biotechnological applications, with analgesic, antioxidant, anticoagulant, anti-inflammatory, antithrombotic, neuroprotective effects and as material for the synthesis of antivirals [43][44][45][46][47].…”

Section: Metabolite Amountsmentioning

confidence: 99%

Classical Food Quality Attributes and the Metabolic Profile of Cambuci, a Native Brazilian Atlantic Rainforest Fruit

et al. 2021

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The cambuci is a native Brazilian fruit from the Atlantic Forest biome. A soft and astringent pulp, a green color, and a sweet aroma are its main characteristics. Classical food quality attributes (fresh fruit mass, fruit height, diameters, total soluble solid, titratable acidity, and ratio) and the metabolic profile from ten accessions from three different locations were analyzed herein by analytical methods (refractometry and neutralization titration) and nuclear magnetic resonance spectroscopy. Concerning sugar content, sucrose was the predominant compound, with glucose and fructose alternating in second, depending on the accession. Citric acid was the most relevant acid, followed by shikimic and quinic acids in quite variable amounts. These three main acids vary in amounts for each accession. Ascorbic acid content emerges as an important quality attribute and makes this fruit nutritionally attractive, due to values comparable to those contained in citric fruits. The main amino acids identified in cambuci were glutamic acid individually or in comprising the tripeptide glutathione (glutamic acid, cysteine, glycine). The quality diversity of the evaluated accessions suggests the potentiality of cambuci use in future breeding programs.

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Section: Metabolite Amountsmentioning

confidence: 99%

Classical Food Quality Attributes and the Metabolic Profile of Cambuci, a Native Brazilian Atlantic Rainforest Fruit

et al. 2021

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“…The SAC in the dried needles of P. sylvestris was 1.60% [34]. The extractable shikimic acid was estimated as 3.79% in Calophyllum brasiliense leaves [35]. The amount of shikimic acid in the fruits of Illicium genus was over 24% on a dry basis [8,36].…”

Section: Mean Variation and Heritabilitymentioning

confidence: 96%

Genetic Parameters and Selection Responses for Important Breeding Traits in Liquidambar formosana Based on a Provenance–Family Trial

Dong,

Zhou,

et al. 2023

Forests

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Liquidambar formosana is a multipurpose tree species native to China. There has been increasing interest in L. formosana due to its leaves being rich in shikimic acid, which plays a key role in the synthesis of the antiviral drug oseltamivir phosphate. Here, shikimic acid content (SAC) and other breeding traits, including tree height (HT), diameter at breast height (DBH), height to crown base (HCB), individual tree volume (VOL), leaf color (LC) and stem straightness degree (SSD), for 387 families of 19 provenances were evaluated in a provenance–family trial of L. formosana to estimate genetic parameters and reveal geographical variation patterns and, ultimately, screen out superior provenances and families. Differences among provenances and families were significant for all tested traits, indicating a high potential for selective breeding. Broad-sense heritabilities of provenance (hp2 = 0.19–0.57) and family (hf2 = 0.16–0.31) were moderate for most traits. Moderate to strong genetic correlations were found among HT, DBH, VOL, HCB and LC (rA = 0.339–0.982), while adverse correlations (rA = −0.494 to −0.816) were observed between SAC and growth traits. All target traits, excluding SSD, exhibited clinal variation in response to latitudinal gradients, and a clustering heatmap divided the 19 provenances into three groups. For single-trait selection, SAC persistently had the highest genetic gains (85.14%–163.57%). A weighted index based on breeding values was used to concomitantly improve SAC, HT and DBH. At a selection rate of 25%, the genetic gains at the provenance and family levels for SAC were 36.42% and 73.52%, and those for core growth traits ranged from −2.29% to 3.49% and 4.05% to 4.47%, respectively. As far as we know, this is the first study in L. formosana to explore the inheritance of SAC and its correlations with other traditional breeding traits. The genetic parameter estimations contribute to a better understanding of the genetic basis of SAC, and the superior provenances and families obtained lay a material foundation for the development of new varieties rich in shikimic acid, thereby promoting the in-depth exploitation and utilization of germplasm resources of L. formosana.

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“…On the other hand, shikimic acid is fundamental for plant metabolism, producing l-phenylalanine and l-tryptophan, which are essential amino acids for humans (Krämer et al, 2003). Furthermore, this compound is used in the synthesis of the antiviral agent oseltamivir phosphate, which is employed against the human influenza virus A and B (Marchiosi et al, 2019). Pereira et al (2015), irradiating Ginkgo biloba (1 and 10 kGy) also observed that the treatment preserved compounds such as quinic and shikimic acids.…”

Section: Identification and Quantification Of Phenolic Compounds In Fmentioning

confidence: 99%

Pytochemical profile and antioxidant activity of chiltepin chili ( Capsicum annuum var. glabriusculum), Sonora, Mexico

Vazquez-Flores¹,

Góngora-Pérez²,

Olivas-Orduña³

et al. 2020

Journal of Food Bioactives

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The effect of processing on potential changes of antioxidant activity (DPPH and ABTS), total phenolic content (TPC) and total flavonoids (FLAV) of feijoa pulp during storage was investigated. In addition, possible modifications in the phenolic composition of the pulp. The pulp was subjected to refrigeration (control, 5 °C), pasteurization (85 °C/5 min) and irradiation (2.0 kGy). TPC, FLAV, DPPH and ABTS were measured during 28 days, whereas the identification and quantification of phenolic compounds were conducted after processing. The results were submitted to principal component analysis (SAS 9.4). Pasteurization preserved TPC, DPPH and ABTS for 21 days, while in the irradiated samples and control, the values were decreased and FLAV were maintained at high levels. The profile of phenolic compounds was different for each sample with six compounds being identified.

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Calophyllum brasiliense Cambess: An alternative and promising source of shikimic acid

Cited by 5 publications

References 35 publications

Classical Food Quality Attributes and the Metabolic Profile of Cambuci, a Native Brazilian Atlantic Rainforest Fruit

Classical Food Quality Attributes and the Metabolic Profile of Cambuci, a Native Brazilian Atlantic Rainforest Fruit

Genetic Parameters and Selection Responses for Important Breeding Traits in Liquidambar formosana Based on a Provenance–Family Trial

Pytochemical profile and antioxidant activity of chiltepin chili ( Capsicum annuum var. glabriusculum), Sonora, Mexico

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