Caloric Restriction and Remission of Severe Chronic Spontaneous Urticaria: An Autobiographical Case Report

Abrahim, Mohammed

doi:10.7759/cureus.19371

Cited by 3 publications

(3 citation statements)

References 15 publications

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“…It has been suggested that there is a significant association between CU with greater affected body surface and heavier weight and higher BMI [23]. Therefore, it seems likely that visceral fat reduction significantly improves inflammation and reduces immune markers [24], yet we could not find such a relationship in this study.…”

Section: Discussioncontrasting

confidence: 66%

Chronic Urticaria: Seeking the Causes in Iranian Population

Azarafraz

Hemmatyar²,

Abachi³

et al. 2022

Immunoregulation

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Background: Chronic urticaria (CU) is the recurrence of erythematous itching papular skin lesions for at least 6 weeks. Although it is often considered a benign condition, there are reports of the association of chronic idiopathic urticaria with infections, thyroid disease, foods, medications, autoimmunity, neoplasms, and low serum level of vitamin D. We aimed to identify the effect of lifestyle characteristics, environmental factors, family history, and specific comorbidities as potential external eliciting factors on the onset of chronic urticaria. Materials and Methods: The present research was conducted on 141 adult patients diagnosed by CU at the allergy clinics of Azad University hospitals in Tehran from January 2021 to January 2022. A questionnaire on different life events during the past 3 months before the onset of urticaria was developed to evaluate the characteristics of the patients with chronic urticaria. Meanwhile, 58 healthy individuals who were similar to the patients in terms of age range and gender were asked to participate in the study as the control group. Results: The mean age of the patients and the controls were 41.7 years and 39.8 years, respectively. The female and male patients were 105(74.47%) and 36(25.53%), respectively. Only two of the evaluated predisposing factors were meaningful including the use of new medications (23.4% versus 19%; P=0.006) and the co-existence of anxiety and depression (14.1% versus 4%; P=0.036). Conclusion: Among the different factors evaluated in this study, only two were found to be significant in relationship with CU which are anxiety/depression and medications.

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Section: Discussioncontrasting

confidence: 66%

Chronic Urticaria: Seeking the Causes in Iranian Population

Azarafraz

Hemmatyar²,

Abachi³

et al. 2022

Immunoregulation

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“…In an autobiographical case report, the physician–author–patient reported remission of his own severe CSU associated with angio‐oedema [Urticaria Activity Severity score over 7 days (UAS7) of 35; poor response with oral cetirizine 20 mg thrice daily] in response to caloric restriction and subsequent weight loss (reduction in UAS7 from 37 to 0, in BMI from 37 to 24.7 and in waist circumference from 122 cm to 85 cm) 67 …”

Section: Dermatological Conditionsmentioning

confidence: 99%

Does weight loss lead to improvement of dermatological conditions: what is the evidence?

Rout

Das

2022

Clinical and Experimental Dermatology

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Obese and overweight individuals may have a wide spectrum of cutaneous features and can have more severe manifestations of multiple dermatological conditions. There have been multiple expert opinions on the role of weight loss, in the improvement of skin conditions. There have been few studies over the past decade evaluating the effects of exercise and other modes of weight reduction on various dermatoses such as psoriasis, acne vulgaris, hidradenitis suppurativa and acanthosis nigricans. In this review, we have attempted to provide a summary of the beneficial effects of weight loss on various dermatological conditions.

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“…Andererseits ergibt sich das Potenzial, durch eine verbesserte metabolische Situation die Krankheitsaktivität und damit einhergehend die Krankheitslast für CSU-Betroffene zu reduzieren. So kann ein autobiografischer Bericht beispielhaft angebracht werden, bei welchem eine gewollte Gewichtsreduktion von 30 kg in 6 Monaten zu einer Reduktion der Urtikaria-Aktivität sowie eine Verminderung der täglichen Antihistaminika-Dosis bei einem Patienten mit seit 28 Jahren bestehender CSU führte 82 . Das Erkennen und die damit einhergehende Präventions- und Behandlungsmöglichkeit metabolischer Erkrankungen bei CSU-Patienten sollte vermehrt in den Fokus betreuender Ärzte treten und möglicherweise im Verlauf zu den standardmäßigen Empfehlungen der Leitlinie aufgenommen werden.…”

Section: Immunologische Dysregulation Und Systemische Inflammation Be...unclassified

Chronische spontane Urtikaria, Adipositas und metabolische Erkrankungen

Zarnowski

Simon

Treudler

2022

Adipositas - Ursachen, Folgeerkrankungen, Therapie

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Zusammenfassung Ziel Darstellung der aktuellen Literatur und neuer Erkenntnisse zum Zusammenhang der chronisch spontanen Urtikaria (CSU) mit Adipositas-assoziierter Inflammation und metabolischen Erkrankungen. Methodik Eine englischsprachige, Pubmed-basierte Literaturrecherche mit den Stichwörtern „chronic urticaria“ und „hypertension“, „hyperlipidemia“, „metabolic syndrome“, „metabolic diseases“, „obesity“, „overweight“, „glucose intolerance“, „diabetes“ sowie zu „cytokines“, „pro-inflammatory“, „adipokines“, „immunological dysregulation“. Ergebnisse In der aktuellen Literatur zeigen sich erhöhte Prävalenzen für Adipositas, Diabetes mellitus, Hyperlipidämie und Hypertonie bei CSU-Patienten. Zudem zeigen sich signifikante Assoziationen zwischen metabolischen Komorbiditäten und der klinischen Ausprägung, Krankheitsdauer oder dem therapeutischen Ansprechen bei der CSU. Darüber hinaus lassen sich gemeinsame immunologische Merkmale zwischen der CSU und Adipositas erkennen, da eine Dysbalance pro- und anti-inflammatorisch wirksamer Zytokine sowie Adipokine zugunsten eines pro-inflammatorischen Zustandes bei beiden Erkrankungen vorliegt. Die Ableitung klinischer Implikationen in Hinblick auf Screening-, Präventions- oder Interventionsmaßnahmen metabolischer Erkrankungen bei der CSU sollte diskutiert werden.

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Caloric Restriction and Remission of Severe Chronic Spontaneous Urticaria: An Autobiographical Case Report

Cited by 3 publications

References 15 publications

Chronic Urticaria: Seeking the Causes in Iranian Population

Chronic Urticaria: Seeking the Causes in Iranian Population

Does weight loss lead to improvement of dermatological conditions: what is the evidence?

Chronische spontane Urtikaria, Adipositas und metabolische Erkrankungen

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