Caloric restriction attenuates the age-associated increase of adipose-derived stem cells but further reduces their proliferative capacity

Schmuck, Eric G.; Mulligan, Jacob D.; Saupe, Kurt W.

doi:10.1007/s11357-010-9166-4

Cited by 10 publications

(5 citation statements)

References 51 publications

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“…Among the gene sets that were modified in the same direction in liver included ‘Ribosomal_proteins’ and ‘Ceramide_Pathway’, whereas reciprocal regulation of gene sets by CR and SRT2104 in muscle included ‘Boquest_CD31plus_vs_CD31minus_Up’, ‘Stemcell_Neural_Up’, and ‘Iglesias_E2Fminus_Up’ (Fig 2E ). Resident muscle stem cell side population as defined as CD31 (Pecam-1) negative lineage (Motohashi et al ., 2008 ) might be reciprocally affected by SRT2104 or CR (Schmuck et al ., 2011 ).…”

Section: Resultsmentioning

confidence: 99%

SRT 2104 extends survival of male mice on a standard diet and preserves bone and muscle mass

et al. 2014

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Summary Increased expression of SIRT1 extends the lifespan of lower organisms and delays the onset of age-related diseases in mammals. Here, we show that SRT2104, a synthetic small molecule activator of SIRT1, extends both mean and maximal lifespan of mice fed a standard diet. This is accompanied by improvements in health, including enhanced motor coordination, performance, bone mineral density and insulin sensitivity associated with higher mitochondrial content and decreased inflammation. Short-term SRT2104 treatment preserves bone and muscle mass in an experimental model of atrophy. These results demonstrate it is possible to design a small molecule that can slow aging and delay multiple age-related diseases in mammals, supporting the therapeutic potential of SIRT1 activators in humans.

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Section: Resultsmentioning

confidence: 99%

SRT 2104 extends survival of male mice on a standard diet and preserves bone and muscle mass

et al. 2014

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“…In [ 84 ], it was shown that CR reduces the percentage of ASC in the lin − SVF while also reducing colony-forming ability. Therefore, it was postulated that CR appears to have antiproliferative effects on ASCs that may be advantageous from the perspective of cancer.…”

Section: The Influence Of Ier On Humansmentioning

confidence: 99%

The Role of Intermittent Energy Restriction Diet on Metabolic Profile and Weight Loss among Obese Adults

et al. 2022

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Obesity is a disease defined by an elevated body mass index (BMI), which is the result of excessive or abnormal accumulation of fat. Dietary intervention is fundamental and essential as the first-line treatment for obese patients, and the main rule of every dietary modification is calorie restriction and consequent weight loss. Intermittent energy restriction (IER) is a special type of diet consisting of intermittent pauses in eating. There are many variations of IER diets such as alternate-day fasting (ADF) and time-restricted feeding (TRF). In the literature, the IER diet is known as an effective method for bodyweight reduction. Furthermore, IER diets have a beneficial effect on systolic or diastolic pressure, lipid profile, and glucose homeostasis. In addition, IER diets are presented as being as efficient as a continuous energy restriction diet (CER) in losing weight and improving metabolic parameters. Thus, the IER diet could present an alternative option for those who cannot accept a constant food regimen.

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“…[63] The effects of CR is mediated by SIRT1, which participates in the extension of organismal life span by modulating DNA damage reactions. [64,65] White adipose tissue is the future of regenerative medicine because it serves as a source of mesenchymal stem cells. Age and CR leads to a wide remodeling of white adipose tissue but how this remodeling in uences the resident stem cell population requires more studies.…”

Section: Cells Stemnessmentioning

confidence: 99%

Cyclic Feeding Regime Stimulates Chromatin Condensation in the Hepatocytes Nuclei of Old Rats

Danladi

Serakinci

Ivanovich³

et al. 2023

Preprint

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Aging related Human malignancies and diseases are linked to flaws in chromatin condensation, which may be due to its significance in the segregation of chromosome, regulation of genes and apoptosis. Investigations of CR (Calorie Restriction) have given a significant information on the mechanisms that control cell reactions to metabolic variations and how these structures function in synergy towards ensuring a harmonized reaction, chromatin plays a vital part in this process. CFR (Cyclic feeding regime) is more beneficial than CR in that it is easy to carry out. Therefore the reason for this investigation was to investigate the effect of CFR on chromatin condensation in the hepatocytes nuclei of 20 months old rats. DNA accessibility assay was used as a marker for chromatin condensation using Acridine Orange,DNA accessibility is the ability of A.O to intercalate and stain the DNA structure .Thus from the DNA accessibility results DNA condensation increased to 66% with 34% DNA accessibility after the first fasting with a reduction to 41% with 59% DNA accessibility following refeeding. The second fasting-refeeding regime lead to a sharp 74% increase and 35% decrease in DNA condensation with 26% and 65% DNA accessibility respectively. They results showed that old animals responded to CFR, with they consecutive fasting regime increasing the chromatin condensation.

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Caloric restriction attenuates the age-associated increase of adipose-derived stem cells but further reduces their proliferative capacity

Cited by 10 publications

References 51 publications

SRT 2104 extends survival of male mice on a standard diet and preserves bone and muscle mass

SRT 2104 extends survival of male mice on a standard diet and preserves bone and muscle mass

The Role of Intermittent Energy Restriction Diet on Metabolic Profile and Weight Loss among Obese Adults

Cyclic Feeding Regime Stimulates Chromatin Condensation in the Hepatocytes Nuclei of Old Rats

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