Caloric restriction improves the redox homeostasis in the aging male rat heart even when started in middle-adulthood and when the body weight is stable

Şimşek, Bahadir; Yanar, Karolin; Kansu, Aydan; Belce, Ahmet; Aydın, Seval; Çakatay, Ufuk

doi:10.1007/s10522-018-9781-5

Cited by 19 publications

(6 citation statements)

References 47 publications

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“…[35] caloric restriction plays an important regulatory role in reducing oxidative stress damage and inflammation, improving telomerase activity, activating autophagy, and improving mitochondrial dysfunction. [36,37] Similarly, exercise may increase antioxidant capacity by increasing reactive oxygen scavenging enzymes, while acting as an induced form of physiological stress may slow or reverse the process of cardiac aging. [38] Interventions such as enhancement of autophagy and improvement of mitochondrial dysfunction can delay or even reverse the process of cardiac aging.…”

Section: Discussionmentioning

confidence: 99%

Bibliometric analysis of trends in cardiac aging research over the past 20 years

Hao,

Li,

Huber

et al. 2023

Medicine

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Background: In recent years, many studies have addressed cardiac aging and related diseases. This study aims to understand the research trend of cardiac aging and find new hot issues. Methods: We searched the web of science core collection database for articles published between 2003 and 2022 on the topic of “cardiac aging.” Complete information including keywords, publication year, journal title, country, organization, and author were extracted for analysis. The VOS viewer software was used to generate network maps of keywords, countries, institutions, and author relationships for visual network analysis. Results: A total of 1002 papers were analyzed in the study. Overall, the number of annual publications on cardiac aging has increased since 2009, and new hot topics are emerging. The top 3 countries with the most publications were the United States (471 articles), China (209 articles) and Italy (101 articles). The University of Washington published the most papers (35 articles). The cluster analysis with author as the keyword found that the connections among different scholars are scattered and clustered in a small range. Network analysis based on keyword co-occurrence and year of publication identified relevant features and trends in cardiac aging research. According to the results of cluster analysis, all the articles are divided into 4 topics: “mechanisms of cardiac aging”, “prevention and treatment of cardiac aging”, “characteristics of cardiac aging”, and “others.” In recent years, the mechanism and treatment of cardiac aging have attracted the most attention. In both studies, animal models are used more often than in human populations. Mitochondrial dysfunction, autophagy and mitochondrial autophagy are hotspots in current research. Conclusion: In this study, bibliometric analysis was used to analyze the research trend of cardiac aging in the past 20 years. The mechanism and treatment of cardiac aging are the most concerned contents. Mitochondrial dysfunction, autophagy and mitophagy are the focus of future research on cardiac aging.

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Section: Discussionmentioning

confidence: 99%

Bibliometric analysis of trends in cardiac aging research over the past 20 years

Hao,

Li,

Huber

et al. 2023

Medicine

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“…In rats, CR restored redox homeostasis in aged hearts [ 258 ], delayed skeletal muscle degeneration [ 259 ], postponed aging-correlative recession in locomotor activity [ 260 ], alleviated aging-related metabolic disorders [ 261 ], remodeled age-related methylation pattern[ 262 ], and even caused epigenetic age deceleration [ 263 ]. In terms of longevity, in the last century, people have observed that 40% of long-term CR maintains cellular replication capacity and increases both average lifespan and maximum lifespan by 36% and 20%, respectively [ 264 ].…”

Section: Conserved Role Of Dietary Restriction In Aging and Cancersmentioning

confidence: 99%

Common Pathogenetic Mechanisms Underlying Aging and Tumor and Means of Interventions

Shen¹,

He²,

Hou³

et al. 2022

Aging and disease

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Recently, there has been an increase in the incidence of malignant tumors among the older population. Moreover, there is an association between aging and cancer. During the process of senescence, the human body suffers from a series of imbalances, which have been shown to further accelerate aging, trigger tumorigenesis, and facilitate cancer progression. Therefore, exploring the junctions of aging and cancer and searching for novel methods to restore the junctions is of great importance to intervene against aging-related cancers. In this review, we have identified the underlying pathogenetic mechanisms of aging-related cancers by comparing alterations in the human body caused by aging and the factors that trigger cancers. We found that the common mechanisms of aging and cancer include cellular senescence, alterations in proteostasis, microbiota disorders (decreased probiotics and increased pernicious bacteria), persistent chronic inflammation, extensive immunosenescence, inordinate energy metabolism, altered material metabolism, endocrine disorders, altered genetic expression, and epigenetic modification. Furthermore, we have proposed that aging and cancer have common means of intervention, including novel uses of common medicine (metformin, resveratrol, and rapamycin), dietary restriction, and artificial microbiota intervention or selectively replenishing scarce metabolites. In addition, we have summarized the research progress of each intervention and revealed their bidirectional effects on cancer progression to compare their reliability and feasibility. Therefore, the study findings provide vital information for advanced research studies on age-related cancers. However, there is a need for further optimization of the described methods and more suitable methods for complicated clinical practices. In conclusion, targeting aging may have potential therapeutic effects on aging-related cancers.

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“…As mentioned previously, there is evidence that slowing the formation of macromolecules in oxidatively 6 Oxidative Medicine and Cellular Longevity damaged cells may improve cardiac function and prevent cardiac aging. Studies have shown that CR exerts cardioprotective effects partly by improving redox homeostasis and inhibiting oxidative stress in aging male rats, even when body weight remains stable [114]. In this context, CR has the potential to improve cardiac aging.…”

Section: Possible Treatment Strategies Formentioning

confidence: 99%

Cardiac Aging: From Basic Research to Therapeutics

Yan

Sun

et al. 2021

Oxidative Medicine and Cellular Longevity

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With research progress on longevity, we have gradually recognized that cardiac aging causes changes in heart structure and function, including progressive myocardial remodeling, left ventricular hypertrophy, and decreases in systolic and diastolic function. Elucidating the regulatory mechanisms of cardiac aging is a great challenge for biologists and physicians worldwide. In this review, we discuss several key molecular mechanisms of cardiac aging and possible prevention and treatment methods developed in recent years. Insights into the process and mechanism of cardiac aging are necessary to protect against age-related diseases, extend lifespan, and reduce the increasing burden of cardiovascular disease in elderly individuals. We believe that research on cardiac aging is entering a new era of unique significance for the progress of clinical medicine and social welfare.

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Caloric restriction improves the redox homeostasis in the aging male rat heart even when started in middle-adulthood and when the body weight is stable

Cited by 19 publications

References 47 publications

Bibliometric analysis of trends in cardiac aging research over the past 20 years

Bibliometric analysis of trends in cardiac aging research over the past 20 years

Common Pathogenetic Mechanisms Underlying Aging and Tumor and Means of Interventions

Cardiac Aging: From Basic Research to Therapeutics

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