Caloric Restriction Prevents Visceral Adipose Tissue Accumulation and Maintains Erectile Function in Aging Rats

Maio, M. Tina; Hannan, Johanna L.; Komolova, Marina; Adams, Michael

doi:10.1111/j.1743-6109.2012.02681.x

Cited by 16 publications

(10 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It was found functionally in the process of caloric restriction (CR) by regulating caveolin1 (CAV1) [38], which was also identified as its target in this study. Interestingly, CR was also found to be a protective factor in maintaining erectile function in aged rats [39].…”

Section: Discussionmentioning

confidence: 94%

Identification and Characterization of the MicroRNA Profile in Aging Rats with Erectile Dysfunction

Pan

Zhang

Qiu

et al. 2014

The Journal of Sexual Medicine

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 94%

Identification and Characterization of the MicroRNA Profile in Aging Rats with Erectile Dysfunction

Pan

Zhang

Qiu

et al. 2014

The Journal of Sexual Medicine

View full text Add to dashboard Cite

“…This approach minimized weight loss, however, if weight loss approached 10% in individual rats, the diet was then supplemented with normal rat chow and/or Nutri‐Cal. Control rats were calorically restricted (∼20% less than an ad libitum diet) to maintain their initial body weight [43]. Biweekly sampling of blood (<1 mL) from the saphenous vein was obtained for the assessment of serum creatinine and phosphorous as described previously [41,42].…”

Section: Methodsmentioning

confidence: 99%

Calcification of the Internal Pudendal Artery and Development of Erectile Dysfunction in Adenine-Induced Chronic Kidney Disease: A Sentinel of Systemic Vascular Changes

Maio¹,

McCabe²,

Pruss³

et al. 2014

The Journal of Sexual Medicine

Self Cite

View full text Add to dashboard Cite

Introduction Chronic kidney disease (CKD), erectile dysfunction (ED), and cardiovascular disease share common vascular etiologies and risk factors. Aim Using a rat model, this is the first study to characterize the consequences of CKD in the onset and development of ED associated with differential regional vascular calcification and circulatory changes. Methods Stable CKD was generated at 3 weeks in male Sprague-Dawley rats given dietary adenine and progressed until 7 weeks. Mineral content and morphometry were assessed in the internal pudendal arteries (IPAs), thoracic aorta, and carotid artery. Endothelial function was determined via changes in serum von Willebrand factor (VWF) and endothelium-dependent relaxation of the thoracic aorta. Results In severe CKD rats, calcium and phosphate content in all arteries increased, and pulse wave velocity was elevated. Distal IPA segments, in particular, were the first to calcify, but penile tissue per se did not. CKD rats had endothelial dysfunction, as indicated by a decrease in acetylcholine-mediated relaxation (∼40%) and an increase in serum VWF (∼40%), as well as increased lumen diameter (20%) of the distal IPA. Erectile function, assessed using a centrally acting dopaminergic agent, was significantly impaired by 7 weeks (∼40%). Conclusions In CKD, the distal IPA appears to be more susceptible to vascular dysfunction and calcification. Additionally, the onset of ED may be an important sentinel of impending systemic vascular disease. To confirm this concept, future experimental and clinical studies will need to examine a range of vessel types and the use of supplementary methods to assess erectile function.

show abstract

“… 68 A recent study in the same experimental model of rats demonstrated that the caloric restriction preserved both visceral adipose tissue (VAT) accumulation and erectile function; moreover, analysis of body composition showed that enhanced erectile response in calories-restricted rats was well correlated with the lower levels of VAT, indicating that the beneficial effect on erectile function may depend on decrease in adipose tissue. 69 Hannan et al . 70 showed that a combination of exercise and calories restriction may, in part, attenuated the age-related decline in apomorphine-induced erectile function in both normotensive and hypertensive rats, with an inverse correlation between the number of pharmacologically-induced erections and body weight.…”

Section: Effects Of Lifestyle Changes On Erectile Dysfunctionmentioning

confidence: 99%

Lifestyle modifications and erectile dysfunction: what can be expected?

2015

View full text Add to dashboard Cite

Erectile dysfunction (ED) is a common medical disorder whose prevalence is increasing worldwide. Modifiable risk factors for ED include smoking, lack of physical activity, wrong diets, overweight or obesity, metabolic syndrome, and excessive alcohol consumption. Quite interestingly, all these metabolic conditions are strongly associated with a pro-inflammatory state that results in endothelial dysfunction by decreasing the availability of nitric oxide (NO), which is the driving force of the blood genital flow. Lifestyle and nutrition have been recognized as central factors influencing both vascular NO production, testosterone levels, and erectile function. Moreover, it has also been suggested that lifestyle habits that decrease low-grade clinical inflammation may have a role in the improvement of erectile function. In clinical trials, lifestyle modifications were effective in ameliorating ED or restoring absent ED in people with obesity or metabolic syndrome. Therefore, promotion of healthful lifestyles would yield great benefits in reducing the burden of sexual dysfunction. Efforts, in order to implement educative strategies for healthy lifestyle, should be addressed.

show abstract

Caloric Restriction Prevents Visceral Adipose Tissue Accumulation and Maintains Erectile Function in Aging Rats

Cited by 16 publications

References 43 publications

Identification and Characterization of the MicroRNA Profile in Aging Rats with Erectile Dysfunction

Identification and Characterization of the MicroRNA Profile in Aging Rats with Erectile Dysfunction

Calcification of the Internal Pudendal Artery and Development of Erectile Dysfunction in Adenine-Induced Chronic Kidney Disease: A Sentinel of Systemic Vascular Changes

Lifestyle modifications and erectile dysfunction: what can be expected?

Contact Info

Product

Resources

About