Calorie Restriction Mimetics: Upstream-Type Compounds for Modulating Glucose Metabolism

Shintani, Hideya; Shintani, Tomoya; Ashida, Hisashi; Sato, Masashi

doi:10.20944/preprints201811.0179.v1

Cited by 21 publications

(11 citation statements)

References 61 publications

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“…Of note, we do not directly demonstrate that in vivo 2-DG treatment reduces brain glycolysis after TBI. 2-DG is well established as an inhibitor of glycolysis (67) across multiple organ systems, animal models, and disease states (68)(69)(70)(71)(72)(73)(74)(75). We observe acute changes in blood glucose and ketone body levels (Figure 4, I-J) upon administration of 2-DG, consistent with 2-DG's ability to inhibit glycolysis and decrease glucose utilization.…”

Section: Discussionsupporting

confidence: 73%

Glycolytic inhibitor 2-deoxyglucose prevents cortical hyperexcitability after traumatic brain injury

Koenig¹,

Cantú²,

Low³

et al. 2019

JCI Insight

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Section: Discussionsupporting

confidence: 73%

Glycolytic inhibitor 2-deoxyglucose prevents cortical hyperexcitability after traumatic brain injury

Koenig¹,

Cantú²,

Low³

et al. 2019

JCI Insight

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“…Thereafter, activation of SIRTs and autophagy (84) occur. It is considered that 2DG causes delay of age-related dysfunction, and shows effects similar to CR 85 . On some organisms it has been shown that 2DG can stimulate stress response proteins and heat shock protein 70 86 .…”

Section: Caloric Restriction Mimeticsmentioning

confidence: 99%

Aging, Calorie Restriction and Calorie Restriction Mimetics

Čepelak

Dodig

2019

Rad Hrvatske akademije znanosti i umjetnosti

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In line with the increase in the number of older people in the world, the focus of scientists is directed at examining mechanisms of the aging process as well as establishing strategies/interventions in order to slow down aging and achieve longevity. On preclinical testing models, the most effective strategy for this purpose, as well as for the purpose of delaying age-related diseases, nutritional intervention-restriction of calorie (CR) has been demonstrated, but also some alternative forms of calorie restriction. Possible undesirable effects of restriction are still in the testing phase, and it is known that it is generally difficult to implement in humans. Therefore, the new area of research in gerontology has become the discovery and examination of the effects of compounds that mimic the effects of caloric restriction, so called caloric restriction mimetics (CRM). These compounds include numerous compounds of natural origin but also approved medicaments with certain indications. This overview summarizes the latest data on known mechanisms of caloric restriction and more familiar caloric restriction mimetics. Sažetak:Starenje, kalorijske restrikcije i kalorijsko restrikcijska mimetrika U skladu s povećanjem broja starijih ljudi u svijetu, fokus znanstvenika usmjeren je na ispitivanje mehanizama procesa starenja kao i na uspostavljanje strategija / intervencija kako bi se usporilo starenje i postigla dugovječnost. Na predkliničkim modelima ispitivanja, najučinkovitija strategija za ovu svrhu, kao i za odgađanje bolesti povezanih s dobi, pokazana je prehrambena intervencija -ograničenje kalorija, ali i neki alternativni oblici ograničavanja kalorija. Mogući neželjeni učinci restrikcije još su u fazi ispitivanja, a poznato je da je to općenito teško provesti kod ljudi. Stoga je novo područje istraživanja u gerontologiji postalo otkriće i ispitivanje učinaka spojeva koji oponašaju učinke kalorijske restrikcije, takozvane mimetike kalorijske restrikcije. Ti spojevi uključuju brojne spojeve prirodnog podrijetla, ali i odobrene lijekove s određenim indikacijama. Ovaj pregled sažima najnovije podatke o poznatim mehanizmima kalorijskog ograničenja i poznatijim mimeticima za ograničenje kalorija. ključne

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“…Increased breathing can induce the temporary upregulation of ROS, leading to increased anti-oxidative enzyme activity and survival rates. 16) 20) Orally administrated D-All also reduces body weight in rodents, 5) which might affect carbohydrate or lipid metabolism. However, the mechanism underlying the antiaging or antimetabolic effect of D-All is not precise, and the role of the nutrient sensor AMPK should be evaluated in the future.…”

Section: Methodsmentioning

confidence: 99%

D-Allose, a Stereoisomer of D-Glucose, Extends the Lifespan of <i>Caenorhabditis elegans</i> via Sirtuin and Insulin Signaling

et al. 2019

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D-Allose (D-All), C-3 epimer of D-glucose, is a rare sugar known to suppress reactive oxygen species generation and prevent hypertension. We previously reported that D-allulose, a structural isomer of D-All, prolongs the lifespan of the nematode Caenorhabditis elegans. Thus, D-All was predicted to affect longevity. In this study, we provide the first empirical evidence that D-All extends the lifespan of C. elegans. Lifespan assays revealed that a lifespan extension was induced by 28 mM D-All. In particular, a lifespan extension of 23.8 % was achieved (p < 0.0001). We further revealed that the effects of D-All on lifespan were dependent on the insulin gene daf-16 and the longevity gene sir-2.1, indicating a distinct mechanism from those of other hexoses, such as D-allulose, with previously reported antiaging effects.

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Calorie Restriction Mimetics: Upstream-Type Compounds for Modulating Glucose Metabolism

Cited by 21 publications

References 61 publications

Glycolytic inhibitor 2-deoxyglucose prevents cortical hyperexcitability after traumatic brain injury

Glycolytic inhibitor 2-deoxyglucose prevents cortical hyperexcitability after traumatic brain injury

Aging, Calorie Restriction and Calorie Restriction Mimetics

D-Allose, a Stereoisomer of D-Glucose, Extends the Lifespan of <i>Caenorhabditis elegans</i> via Sirtuin and Insulin Signaling

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