Calotropis gigantiea (L.) R. Br (Apocynaceae): A phytochemical and pharmacological review

Kadiyala, Madhuri; Ponnusankar, Sivasankaran; Elango, K

doi:10.1016/j.jep.2013.08.045

Cited by 46 publications

(29 citation statements)

References 32 publications

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“…On the other hand, nanoparticle production using physical methods demands high energy consumption and chemical methods produce hazardous and toxic compounds that reduce the biological applications of generated nanoparticles [11]. In this study, we used C. gigantea L. (Asclepiadaceae) for the green synthesis of AgNPs due to its multiple reported therapeutic potentials, including anti-inflammatory, analgesic, anticonvulsant, anxiolytic, sedative, antidiarrheal, antipyretic, and antimicrobial effects [12,13]. In addition, leaves and areal parts of the plant were reported to have anti-bacterial, anti-fungal [14], and anti-oxidant activities [15].…”

Section: Introductionmentioning

confidence: 99%

Effective Inhibition of Candidiasis Using an Eco-Friendly Leaf Extract of Calotropis-gigantean-Mediated Silver Nanoparticles

Ali

Abdallah

2020

Nanomaterials

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The approaches used for the green biosynthesis of nanoparticles with clinical applications have been widely used in nanotechnology due to their potential to provide safe, eco-friendly, cost effective, high-stability, and high-loading-capacity nanoparticles. This study aimed to evaluate the anti-candidal activity of silver nanoparticles (AgNPs) biosynthesized using the aqueous leaf extract of Calotropis gigantea (CG) alone or in a combination with the plant extract of CG (AgNPs/CG). AgNPs were characterized using UV-Vis spectrophotometry, Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), and X-ray diffraction (XRD). The results of the standard disk diffusion method revealed that AgNPs alone displayed anti-candidal activity (11.33-mm inhibition zone), while AgNPs/CG displayed a strong synergistic anti-candidal activity (17.76-mm inhibition zone). Similarly, AgNPs/CG completely inhibited the growth of C. albicans after 4 h of incubation, as measured using the time-kill assay. In addition, AgNPs/CG inhibited the dimorphic transition of C. albicans and suppressed both the adhesion and the biofilm formation of C. albicans by 41% and 38%, respectively. The treatment of Candida. albicans with AgNPs/CG showed a significant inhibition of the production of several antioxidant enzymes. Interestingly, AgNPs/CG did not show any cytotoxicity in animal cells, including the MCF-7 cell line and primary mouse bone marrow-derived mesenchymal stem cells (mBMSCs), at the concentration used to completely inhibit the dimorphic transition of C. albicans. In conclusion, we identified AgNPs/CG as a promising natural-product-based nanoparticle that can potentially be used as an anti-candidal drug.

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Section: Introductionmentioning

confidence: 99%

Effective Inhibition of Candidiasis Using an Eco-Friendly Leaf Extract of Calotropis-gigantean-Mediated Silver Nanoparticles

Ali

Abdallah

2020

Nanomaterials

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“…Calotropis gigantea is a notorious weed, so far not cultivated commercially. Still, the plant has been screened for different pharmacological activities, in the form of extract of any part, isolated compound or latex, using different scientifically accepted in-vivo or in-vitro models [14]. Based on phytochemicals present, different parts of Calotropis gigantea were reported to possess different pharmacological activities (Table 1).…”

Section: Pharmacological Potential Of Calotropis Giganteamentioning

confidence: 99%

Calotropis gigantea assisted green synthesis of nanomaterials and their applications: a review

Patil

2020

Beni-Suef Univ J Basic Appl Sci

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Background: Nanotechnology has been receiving wonderful impetus in the current emerging technological era by opening a pool of scientific ideas to compete with the daily challenges of developing technology. So far, numerous properties and countless applications of nanomaterials have been explored which have been even proved to be based on characteristic shape, size, surface area and surface chemistry. Main content: By the time, several attempts have been made for green synthesis of nanomaterials, using plant extracts. Calotropis gigantiea (L.) R. Br is the plant belonging to Apocynaceae, have been screened and proved to possess various pharmacological activities, due to different polar phytochemicals like flavonoids, lignans and terpenoids. This review focus on phytochemicals so far reported from different parts of the plant; pharmacological activities exhibited; green synthesis of nanomaterials, particularly metallic nanoparticles green synthesised by facilitating reaction of metallic ion donor molecule/salt and aqueous extract of leaves or flowers of C. gigantiea and their biological or non-biological applications. The use of C. gigantea in the fabrication of nanomaterials is an ecofriendly and safe approach. Secondary metabolites present act as a stabilizing agent for nanomaterials. Cadmium sulphide, titanium dioxide, nickel and nickel oxide nanoparticles synthesised using C. gigantea exerted better antimicrobial action, compared to extracts. Nanoencapsulated magnesium oxide nanoparticles avoided biochemical degradation of MgO; increase its bioavailability and proved beneficial in type II diabetes mellitus. Cupric oxide nanoparticles got applied in dye-sensitised solar cell. Silver nanoparticles showed better cytotoxicity in HeLa cells. Biomaterial-supported zero-valent iron and stannic oxide nanoparticles proved to have utilities in water purification. Green synthesised Eu 3+ doped Y 2 SiO 5 nanophosphors had significant chromaticity coordinates and average correlated colour temperature, hence find application in displays. Conclusion: Variety of nanomaterials including nanoparticles and nanophophors could successfully be biosynthesised using Calotropis gigantean extract or its latex. These green synthesised nanomaterials have several applications in the healthcare system and technology.

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“…It is commonly called as "crown flower" or "giant milk weed" is a well-known weed to many cultures for treating various disorders related to central nervous system, skin diseases, digestive system, respiratory system, reproductive system, etc. [11] It is used as a traditional medicinal plant and is used to treat common disease such as fevers, rheumatism, indigestion, cough, cold, eczema, asthma, elephantiasis, nausea, vomiting, and diarrhea. According to Ayurveda, dried whole plant is a good tonic, expectorant, depurative, and anthelmintic.…”

Section: Original Articlementioning

confidence: 99%

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Mandal

2017

IJGP

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Objective: Extracts of the root of Calotropis gigantea (family: Apocynaceae) have been used as a natural therapeutic agent in traditional medicine to treat inflammation and pain. This study aims to evaluate the antiinflammatory and analgesic activity of methanol extract of C. gigantea root (MECG). Materials and Methods: The analgesic activity of MECG was evaluated using formalin-induced pain and glutamate-induced paw licking models. Antagonism of opioid receptors using naloxone was used to determine the involvement of central pathways of pain. The acute inflammation was measured by carrageenan and dextran-induced paw edema models. Cyclooxygenase (COX) assay was carried out to determine the action of MECG on prostaglandins (PGs). Results: MECG 200 mg/kg dose was found to produce a significant (P < 0.001) and dose-dependent analgesic activity in the models used. MECG caused significant inhibition of edema in the carrageenan and dextran-induced inflammation tests. MECG was found to reduce the expression of COX, thus confirming the inhibitory action of MECG on PGs. Conclusion: The findings suggest that MECG possesses analgesic and antiinflammatory activity mediated through peripheral and central mechanisms. The results justify its traditional use in the treatment of inflammation and pain.

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Calotropis gigantiea (L.) R. Br (Apocynaceae): A phytochemical and pharmacological review

Cited by 46 publications

References 32 publications

Effective Inhibition of Candidiasis Using an Eco-Friendly Leaf Extract of Calotropis-gigantean-Mediated Silver Nanoparticles

Effective Inhibition of Candidiasis Using an Eco-Friendly Leaf Extract of Calotropis-gigantean-Mediated Silver Nanoparticles

Calotropis gigantea assisted green synthesis of nanomaterials and their applications: a review

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