Calotropis poisoning with severe cardiac toxicity A case report

Iyadurai, Ramya; Gunasekaran, Karthik; Jose, Arun; Pitchaimuthu, Kishore

doi:10.4103/jfmpc.jfmpc_783_20

Cited by 14 publications

(7 citation statements)

References 11 publications

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“…Calotropis, a small shrub (sometimes referred to as weed), belongs to the family Apocynaceae. Calotropis is a widely distributed plant in tropical and subtropical zones, comprising two species, procera and gigantea [ 30 ]. In our routine screening of novel lectins from tropical endogenous plants, we have detected a robust hemagglutinating activity (HA) in the Calotropis procera crude leaves extract.…”

Section: Resultsmentioning

confidence: 99%

Purification, Partial Characterization, and Evaluation of the Antiulcer Activity of Calotropis procera Leaf Lectin

Althobaiti

Konozy

2022

PPL

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Background: Lectins are proteins with therapeutic and diagnostic potential that can be applied in battling various ailments. Aim and Objective: This study was designed to purify and characterize the hemagglutinating activity derived from the leaves of Calotropis procera and its possible role in protecting the stomach against ethanol-induced lesions. Methods: The Calotropis procera leaf lectin (ProLec), was isolated by homogenization of the defatted leaf powder in Phosphate-Buffered Saline (PBS) and purified by affinity chromatography on Sephadex G-100. The lectin was eluted from the affinity column by 3% acetic acid and was physicochemically characterized. In a dose-dependent manner, ProLec was administered to rats with ethanol-induced ulcers, Biochemical, histopathological and toxicological examinations were performed. Results: ProLec is a heterodimer of 75 and 68kDa. It agglutinated all human RBCs, whereas it showed weak interaction with animal erythrocytes. The protein was optimally active at 25°C and was labile above this temperature. ProLec exhibited two pH optima and was a metalo-protein requiring Ca, Mn, and Ni. It contains 1.6% tryptophan residues of which about 1% is exposed and critical for lectin activity. The lectin exhibited a potent gastroprotective effect against ethanol-induced gastric lesions with no apparent toxicity to both kidneys and liver. Examination of the pH of the gastric juice of lectin treated animals indicated a possible role of lectin in maintaining stomach acidity within the normal ranges compared to the gastric juice pH of animals that received ethanol only. Conclusion: These results may suggest that ProLec could conceivably be a good future drug for the treatment of gastric ulcers, however, extensive immunological and toxicologically research remains needed.

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Section: Resultsmentioning

confidence: 99%

Purification, Partial Characterization, and Evaluation of the Antiulcer Activity of Calotropis procera Leaf Lectin

Althobaiti

Konozy

2022

PPL

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“…The therapeutic limitations and clinical pitfalls of calotropin as an anticancer agent are represented by insufficient data on adverse and toxic effects in humans. Very few cases have reported some digestive, hepatotoxic adverse effects and only one case with severe cardiotoxicity ( Iyadurai et al, 2020 ). Other important limitations are the lack of clinical studies of calotropin in cancer, and the lack of in vivo studies of calotropin in experimental animal models for all cancers.…”

Section: Limitationsmentioning

confidence: 99%

An updated pharmacological insight into calotropin as a potential therapeutic agent in cancer

et al. 2023

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Calotropin is a pharmacologically active compound isolated from milkweed plants like Calotropis procera, Calotropis gigantea, and Asclepias currasavica that belong to the Asclepiadaceae family. All of these plants are recognised as medical traditional plants used in Asian countries. Calotropin is identified as a highly potent cardenolide that has a similar chemical structure to cardiac glycosides (such as digoxin and digitoxin). During the last few years, cytotoxic and antitumor effects of cardenolides glycosides have been reported more frequently. Among cardenolides, calotropin is identified as the most promising agent. In this updated and comprehensive review, we aimed to analyze and discuss the specific mechanisms and molecular targets of calotropin in cancer treatment to open new perspectives for the adjuvant treatment of different types of cancer. The effects of calotropin on cancer have been extensively studied in preclinical pharmacological studies in vitro using cancer cell lines and in vivo in experimental animal models that have targeted antitumor mechanisms and anticancer signaling pathways. The analyzed information from the specialized literature was obtained from scientific databases until December 2022, mainly from PubMed/MedLine, Google Scholar, Scopus, Web of Science, and Science Direct databases using specific MeSH search terms. The results of our analysis demonstrate that calotropin can be a potential chemotherapeutic/chemopreventive adjunctive agent in cancer pharmacotherapeutic management.

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“…Calotropis procera Linn. is a common shrub mostly found as a weed around India (Iyadurai et al 2020), attributed to warm and dry areas, the sub-Himalayan regions and the southern regions of the country. Different parts of Calotropis procera have been reported to possess different therapeutic activities such as proteolytic (Atal andSethi 1962) antimicrobial, larvicidal (Al-Rowaily et al 2020), nematocidal, anticancer, anti-in ammatory (Basu and Chaudhuri 1991;Kumar and Basu 1994).…”

Section: Introductionmentioning

confidence: 99%

The potentials of Calotropis procera against filarial elephantiasis: an in-silico approach

et al. 2021

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Lymphatic lariasis is one of the major diseases that belong to the category of neglected tropical illness.Filarial nematodes are the cause of the disease and are transmitted to humans via blood-feeding arthropod vectors. Drugs such as Albendazole, Ivermectin and diethylcarbamazine are administered either individually or in combination to overcome the progress of the lymphatic lariasis. However, these drugs have some disadvantages like temporary hair loss, dizziness, nausea etc. The larial parasites have multifunctional proteins including the Glutathione-s-transferase (GST) enzyme which plays a major role in detoxi cation of endogenous electrophilic compounds. This study aims at the identi cation of a natural molecule that has the potential to bind with the GST enzyme and thus interrupt the detoxi cation process within the larial parasite, Brugia malayi. A medicinal plant Calotropis procera, owing to its anthelmintic properties was searched for the presence of potential phytocompounds. The phytocompounds were docked against the homology modeled GST enzyme using the MOE software. The results were screened and analyzed based on the Lipinski rule of 5. N-octanoate was the phytocompound obtained based on molecular docking, subjected to molecular dynamics. These results require further in vitro and in vivo validation to consider n-octanoate as a potential drug candidate for lymphatic lariasis treatment.

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Calotropis poisoning with severe cardiac toxicity A case report

Cited by 14 publications

References 11 publications

Purification, Partial Characterization, and Evaluation of the Antiulcer Activity of Calotropis procera Leaf Lectin

Purification, Partial Characterization, and Evaluation of the Antiulcer Activity of Calotropis procera Leaf Lectin

An updated pharmacological insight into calotropin as a potential therapeutic agent in cancer

The potentials of Calotropis procera against filarial elephantiasis: an in-silico approach

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