Calpain Activity in Leukocytes Is Associated with Diabetes Biochemical Markers

Salazar, Ana Marı́a; Pánico, Pablo; Burns, Anna L.; Dı́az-Villaseñor, Andrea; Torres-Arellano, José M.; Juárez-Nájera, Adriana; González-Pimienta, Rosa Elena; Alvarez-Sekely, Ana Magaly; Zacarías-Castillo, Rogelio; Ostrosky‐Wegman, Patricia

doi:10.1016/j.arcmed.2019.11.009

Cited by 2 publications

(1 citation statement)

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“…Glucose metabolism and glucose uptake are necessary to maintain proper lymphocyte function and to sustain proliferation in the presence of immunogenic stimulus ( 187 – 190 ). Also, the lymphocytes from T2D patients had reduced glucose metabolism, the expression of the GLUT transporters, and the activity of calpains, which are proteases involved in regulating GLUTs ( 191 – 194 ). In vitro treatment of human lymphocytes with up to 1 µM of sodium arsenite for 72 h resulted in reduced GLUT1 trafficking, alterations in glucose uptake and calpain activity ( 195 ).…”

Section: Arsenic Effects On Inflammation and Immune Systemmentioning

confidence: 99%

Is Arsenic Exposure a Risk Factor for Metabolic Syndrome? A Review of the Potential Mechanisms

et al. 2022

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Exposure to arsenic in drinking water is a worldwide health problem. This pollutant is associated with increased risk of developing chronic diseases, including metabolic diseases. Metabolic syndrome (MS) is a complex pathology that results from the interaction between environmental and genetic factors. This condition increases the risk of developing type 2 diabetes, cardiovascular diseases, and cancer. The MS includes at least three of the following signs, central obesity, impaired fasting glucose, insulin resistance, dyslipidemias, and hypertension. Here, we summarize the existing evidence of the multiple mechanisms triggered by arsenic to developing the cardinal signs of MS, showing that this pollutant could contribute to the multifactorial origin of this pathology.

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