Calpastatin peptide attenuates early brain injury following experimental subarachnoid hemorrhage

Teng, Fei; Yin, Yanxin; Guo, Jia; Jiang, Ming

doi:10.3892/etm.2020.8510

Cited by 3 publications

(2 citation statements)

References 35 publications

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“…The CAST is a cell-permeable peptide that acts as an endogenous inhibitor of calpain in the central nervous system [ 73 , 74 ]. Calpains are cysteine proteases that are activated by calcium, that is, they are positively regulated by calcium and negatively regulated by CAST [ 75 , 76 ].…”

Section: Discussionmentioning

confidence: 99%

Brain fatty acid and transcriptome profiles of pig fed diets with different levels of soybean oil

et al. 2023

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Background The high similarity in anatomical and neurophysiological processes between pigs and humans make pigs an excellent model for metabolic diseases and neurological disorders. Lipids are essential for brain structure and function, and the polyunsaturated fatty acids (PUFA) have anti-inflammatory and positive effects against cognitive dysfunction in neurodegenerative diseases. Nutrigenomics studies involving pigs and fatty acids (FA) may help us in better understanding important biological processes. In this study, the main goal was to evaluate the effect of different levels of dietary soybean oil on the lipid profile and transcriptome in pigs’ brain tissue. Results Thirty-six male Large White pigs were used in a 98-day study using two experimental diets corn-soybean meal diet containing 1.5% soybean oil (SOY1.5) and corn-soybean meal diet containing 3.0% soybean oil (SOY3.0). No differences were found for the brain total lipid content and FA profile between the different levels of soybean oil. For differential expression analysis, using the DESeq2 statistical package, a total of 34 differentially expressed genes (DEG, FDR-corrected p-value < 0.05) were identified. Of these 34 DEG, 25 are known-genes, of which 11 were up-regulated (log2 fold change ranging from + 0.25 to + 2.93) and 14 were down-regulated (log2 fold change ranging from − 3.43 to -0.36) for the SOY1.5 group compared to SOY3.0. For the functional enrichment analysis performed using MetaCore with the 34 DEG, four pathway maps were identified (p-value < 0.05), related to the ALOX15B (log2 fold change − 1.489), CALB1 (log2 fold change − 3.431) and CAST (log2 fold change + 0.421) genes. A “calcium transport” network (p-value = 2.303e-2), related to the CAST and CALB1 genes, was also identified. Conclusion The results found in this study contribute to understanding the pathways and networks associated with processes involved in intracellular calcium, lipid metabolism, and oxidative processes in the brain tissue. Moreover, these results may help a better comprehension of the modulating effects of soybean oil and its FA composition on processes and diseases affecting the brain tissue.

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Section: Discussionmentioning

confidence: 99%

Brain fatty acid and transcriptome profiles of pig fed diets with different levels of soybean oil

et al. 2023

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“…There are many clinical studies regarding the perioperative use of dexamethasone to reduce neurological complications in cervical spine surgery [ 199 – 201 ] but not BSCB disruption per se. Inhibiting proinflammatory cascades via attenuation of TNFα signaling and calpain with infliximab and calpastatin respectively restored BBB permeability and promoted endothelial cell survival and TJ expression in mouse models of subarachnoid hemorrhage (SAH) and traumatic brain injury (TBI) [ 202 – 204 ]. Compounds derived from natural herbs that possess anti-inflammatory or antioxidant activity, such as shikonin, curcumin, and salvianolic acid B have also demonstrated efficacy in rat models of SCI [ 205 – 208 ].…”

Section: Potential Therapeutic Strategies To Ameliorate Bscb Disruptionmentioning

confidence: 99%

Blood-spinal cord barrier disruption in degenerative cervical myelopathy

Kim,

Yong,

Shea

2023

Fluids Barriers CNS

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Degenerative cervical myelopathy (DCM) is the most prevalent cause of spinal cord dysfunction in the aging population. Significant neurological deficits may result from a delayed diagnosis as well as inadequate neurological recovery following surgical decompression. Here, we review the pathophysiology of DCM with an emphasis on how blood-spinal cord barrier (BSCB) disruption is a critical yet neglected pathological feature affecting prognosis. In patients suffering from DCM, compromise of the BSCB is evidenced by elevated cerebrospinal fluid (CSF) to serum protein ratios and abnormal contrast-enhancement upon magnetic resonance imaging (MRI). In animal model correlates, there is histological evidence of increased extravasation of tissue dyes and serum contents, and pathological changes to the neurovascular unit. BSCB dysfunction is the likely culprit for ischemia–reperfusion injury following surgical decompression, which can result in devastating neurological sequelae. As there are currently no therapeutic approaches specifically targeting BSCB reconstitution, we conclude the review by discussing potential interventions harnessed for this purpose.

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Neuroprotective Effects of Piceatannol on Olfactory Bulb Injury after Subarachnoid Hemorrhage

et al. 2023

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Calpastatin peptide attenuates early brain injury following experimental subarachnoid hemorrhage

Cited by 3 publications

References 35 publications

Brain fatty acid and transcriptome profiles of pig fed diets with different levels of soybean oil

Brain fatty acid and transcriptome profiles of pig fed diets with different levels of soybean oil

Blood-spinal cord barrier disruption in degenerative cervical myelopathy

Neuroprotective Effects of Piceatannol on Olfactory Bulb Injury after Subarachnoid Hemorrhage

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