Calprotectin in Cystic Fibrosis

Rumman, Nisreen; Sultan, Mutaz; El‐Chammas, Khalil; Goh, Vi Lier; Salzman, Nita H.; Quintero, Diana; Werlin, Steven L.

doi:10.1186/1471-2431-14-133

Cited by 41 publications

(68 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[21] Serum S100A8 levels have been shown to increase in inflammatory disease, such as autoimmune disease (including rheumatoid arthritis and inflammatory bowel disease), various types of cancer, cystic fibrosis, and neurodegeneration. [22][23][24] In our study, serum S100A8 levels were higher in females with PCOS compared to controls.…”

Section: Discussionsupporting

confidence: 49%

“…Calgranulin A (S100A8) is a low molecular weight protein with calcium binding properties that is released by activated granulocytes and mediates inflammatory signaling pathways, such as the NF‐kB pathway . Serum S100A8 levels have been shown to increase in inflammatory disease, such as autoimmune disease (including rheumatoid arthritis and inflammatory bowel disease), various types of cancer, cystic fibrosis, and neurodegeneration . In our study, serum S100A8 levels were higher in females with PCOS compared to controls.…”

Section: Discussionmentioning

confidence: 52%

See 1 more Smart Citation

Polycystic Ovary Syndrome and Insulin Physiology: An Observational Quantitative Serum Proteomics Study in Adolescent, Normal‐Weight Females

Manousopoulou

Al‐Daghri

Sabico

et al. 2019

Proteomics Clinical Apps

View full text Add to dashboard Cite

Background Polycystic ovary syndrome (PCOS) is a common endocrine disorder associated with insulin resistance, even in the absence of overweight/obesity. The aim of the present study is to examine the global serum proteomic profile of adolescent, normal‐weight females with PCOS in order to gain novel insight in the association of this endocrine disorder with insulin physiology and to identify novel circulating markers that can guide intervention protocols. Methods Non‐depleted serum from normal‐weight (BMI: 18–23 kg m−2), adolescent females (13–21 years old) with PCOS (n = 20) is compared to BMI‐ and age‐matched healthy controls (n = 20) using our 3D quantitative proteomics methodology. Serum samples from study participants are randomly pooled to form four biological replicates of females with PCOS and four of healthy controls (n = 5 per sample pool). Results One‐hundred and twenty‐six proteins are differentially expressed in females with PCOS compared to controls. Gene ontology analysis shows significant enrichment for terms related to inflammatory immune response, metabolism and insulin‐like growth factor receptor signaling pathway. Circulating levels of IGF‐1 and ‐2 and IGFBP‐2, ‐3, and ‐4 are found to be lower in females with PCOS compared to healthy controls. Conclusions The present serum proteomics study provides insight into the pro‐inflammatory status and insulin dysregulation in young females with PCOS and identifies potential serological markers that can guide early intervention protocols.

show abstract

Section: Discussionsupporting

confidence: 49%

Section: Discussionmentioning

confidence: 52%

Polycystic Ovary Syndrome and Insulin Physiology: An Observational Quantitative Serum Proteomics Study in Adolescent, Normal‐Weight Females

Manousopoulou

Al‐Daghri

Sabico

et al. 2019

Proteomics Clinical Apps

View full text Add to dashboard Cite

show abstract

“…The presence of mutation in the ABCC7/CFTR gene has been associated with cystic brosis (CF) which is a prevalent disease in white populations, dysfunction and changes in gene expression has been implicated in other diseases development, including chronic in ammation 11,12 . In patients with CF has been observed an increase of fecal calprotectin as same as happens in the in ammatory bowel disease (IBD) [13][14][15] . The ABCC7/CFTR knock-out mice model developed intestinal in ammation suggesting a role of this gene in the gut in ammation 12,16 .…”

Section: Introductionmentioning

confidence: 72%

“…It is well known that CFTR has been widely studied in cystic brosis (CF) and recently, it has grown interest in to study its role in other diseases or in ammatory conditions such as in the biliary epithelium and intestine 12,22−24 . In animal models and in vitro studies have demonstrated the role of CFTR in the intestinal in ammatory process characterized by histological in ltration of immune cells and increased of in ammatory fecal biomarkers [13][14][15][16] .…”

Section: Discussionmentioning

confidence: 99%

ABCC7/CFTR Expression is Down-regulated in Patients with Active Ulcerative Colitis

Yamamoto-Furusho

Villeda‐Ramírez

Meza-Guillén

et al. 2020

Preprint

View full text Add to dashboard Cite

Background Inflammatory Bowel Disease includes Ulcerative Colitis (UC) and Crohn´s disease (CD) of unknown etiology. The expression of ATP Binding Cassette Family proteins (ABC) has been associated with drug resistance and development of UC. The Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) or also known as ABCC7 is involved in the inflammatory chronic response. The aim of the study was to evaluate the role of ABCC7/CFTR in UC patients and normal controls without inflammation.Results A total of 62 patients with UC and normal controls were included. We found a significant downregulation of CFTR gene expression in patients with active UC compared to remission UC and normal controls without inflammation (P<0.004 and P<0.0001 respectively) even the gene expression of CFTR was decreased in remission UC patients compared to normal controls (P=0.047). The CFTR gene expression was associated with persistent activity of UC and young age at diagnosis before 40 years. The protein expression of CFTR was decreased in severe active UC patients compared to normal controls without inflammation. ConclusionThe CFTR gene and protein expression were significantly decreased in active UC patients and it was also associated with clinical outcomes.

show abstract

“…[36]. Fecal calprotectin is often elevated in individuals with CF; however, the correlation of these levels with the degree of intestinal inflammation is not well characterized, although studies are ongoing [37,38].…”

Section: Symptom Diarymentioning

confidence: 99%

Approach to chronic abdominal pain in Cystic Fibrosis

Lusman

Grand

2017

Journal of Cystic Fibrosis

View full text Add to dashboard Cite

Abdominal pain in individuals with CF is challenging for the patient as well as the physician, as the differential diagnosis can be complex. Most gastrointestinal manifestations of CF present with regional abdominal pain. Pain localization, which requires knowledge of gut development and innervation, is crucial to understanding the pathophysiology of abdominal pain in CF. The location of the pain, together with the clinical presentation, shapes the differential diagnosis and thus guides the evaluation and management.

show abstract

Calprotectin in Cystic Fibrosis

Cited by 41 publications

References 24 publications

Polycystic Ovary Syndrome and Insulin Physiology: An Observational Quantitative Serum Proteomics Study in Adolescent, Normal‐Weight Females

Polycystic Ovary Syndrome and Insulin Physiology: An Observational Quantitative Serum Proteomics Study in Adolescent, Normal‐Weight Females

ABCC7/CFTR Expression is Down-regulated in Patients with Active Ulcerative Colitis

Approach to chronic abdominal pain in Cystic Fibrosis

Contact Info

Product

Resources

About