Calprotectin in gingival crevicular fluid correlates with clinical and biochemical markers of periodontal disease

Kido, Jun‐ichi; Nakamura, Teruo; Kido, Reiko; Ohishi, Keiji; Yamauchi, Noriyuki; Kataoka, Masatoshi; Nagata, Toshihiko

doi:10.1034/j.1600-051x.1999.261004.x

Cited by 90 publications

(104 citation statements)

References 27 publications

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“…The present data indicated that GCF calprotectin levels increased as the periodontal disease progresses from health to disease, but similar in G-AgP and CP. Our findings are consistent with the previous data showing the role of calprotectin as an inflammatory marker of periodontal disease [11,12,42,43]. Kaner et al [44] have demonstrated that GCF calprotectin levels are significantly correlated with the levels of periodontal inflammation and decreased after periodontal therapy in G-AgP patients.…”

Section: Discussionsupporting

confidence: 83%

“…Although this technique provides larger GCF volumes compared to superficial intracrevicular technique [40], in accor- dance with the suggestions of others our discussion of the data as well as studying relationship with clinical data was based on the total amount rather than concentration of the data which consider the amount of GCF collected [37,41]. The relationship between GCF calprotectin levels and several other inflammatory markers has been previously investigated and calprotectin levels were shown to be a significant contributor to host defense against infection [8,9,42,43]. The present data indicated that GCF calprotectin levels increased as the periodontal disease progresses from health to disease, but similar in G-AgP and CP.…”

Section: Discussionmentioning

confidence: 99%

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Gingival Crevicular Fluid Calprotectin, Osteocalcin and Cross-Linked N-Terminal Telopeptid Levels in Health and Different Periodontal Diseases

et al. 2011

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Abstract. Aim:The aim of the present study was to investigate gingival crevicular fluid (GCF) calprotectin, osteocalcin and cross-linked N-terminal telopeptide (NTx) levels in health along with different periodontal diseases. Material and methods: Twenty chronic periodontitis (CP), 20 generalized aggressive periodontitis (G-AgP), 20 gingivitis and 20 healthy subjects were included. Probing depth, clinical attachment level, plaque index and papillary bleeding index was recorded. GCF calprotectin, osteocalcin and NTx levels were analyzed by enzyme-linked immunosorbent assay (ELISA). Results: CP, G-AgP and gingivitis groups had higher GCF calprotectin total amount compared to healthy subjects (p < 0.008). CP and G-AgP groups had similar, but higher levels compared to gingivitis groups (p < 0.008). CP and G-AgP groups had lower GCF osteocalcin total amount compared to gingivitis and healthy groups (p < 0.008). CP group had higher GCF NTx but lower osteocalcin total amount and osteocalcin/NTx ratio than the G-AgP group (p < 0.008). Conclusions: Our results suggest that elevated GCF calprotectin levels play a role as a reliable inflammatory marker in the pathogenesis of periodontal disease. Fluctuating GCF levels of osteocalcin and NTx might point out to the abnormal bone turnover in periodontitis. Our data document for the first time the role of NTx in the pathogenesis of different periodontal diseases.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Gingival Crevicular Fluid Calprotectin, Osteocalcin and Cross-Linked N-Terminal Telopeptid Levels in Health and Different Periodontal Diseases

et al. 2011

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“…Recently, we detected calprotectin in Gingival crevicular fluid and its concentrations in periodontal pockets were higher than those in healthy gingival crevices [16,17] . Investigations done by Jun-ichi Kido found the correlations between Gingival crevicular fluid calprotectin levels and clinical indicators (probing depth and bleeding on probing, BOP), and the IL-1β and PgE 2 levels [14] .…”

Section: Effect Site Change In Concentrationmentioning

confidence: 93%

Effect of Gingival Crevicular Fluid Volume in Smokers

2017

IJCRR

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The association between smoking and periodontal disease has been proven by many epidemiological evidences. This article reviews the recent studies and compiles the effect of smoking on Gingival crevicular fluid volume. Many studies support the fact that tobacco smoking affects the periodontium through different pathways like microcirculatory, host immune systems, connective tissue and bone mechanisms.

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“…Kido, J., Nakamura, T., Kido, R., Ohishi, K., Yamauchi, N., Kataoka, M., and Nagata, T. (1999). Calprotectin in gingival crevicular fluid correlates with clinical and biochemical markers of periodontal disease.…”

Section: Acknowledgmentsmentioning

confidence: 99%

“…It is expressed in neutrophils, monocytes, macrophages, and mucosal keratinocytes and is involved in leukocyte trafficking and arachidonic acid metabolism (Nacken et al, 2003). It is upregulated in inflammatory conditions, including periodontal disease in which it is elevated in the gingival cervicular fluid (Kido et al, 1999). It is constitutively expressed in cells of stratified oral epithelia and in cultured gingival epithelial cells and is highly responsive to stress in epidermis (Marionnet et al, 2003).…”

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confidence: 99%

Antimicrobial Peptides in the Oral Environment: Expression and Function in Health and Disease

2005

Current Issues in Molecular Biology

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The oral cavity is a unique environment in which antimicrobial peptides play a key role in maintaining health and may have future therapeutic applications. Present evidence suggests that α-defensins, β-defensins, LL-37, histatin, and other antimicrobial peptides and proteins have distinct but overlapping roles in maintaining oral health and preventing bacterial, fungal, and viral adherence and infection. The expression of the inducible hBD-2 in normal oral epithelium, in contrast to other epithelia, and the apparent differential signaling in response to commensal and pathogenic organisms, provides new insights into innate immunity in this body site. Commensal bacteria are excellent inducers of hBD-2 in oral epithelial cells, suggesting that the commensal bacterial community acts in a manner to benefit the overall innate immune readiness of oral epithelia. This may have major significance for understanding host defense in the complex oral environment. The oral environmentThe oral cavity is a unique environment. Oral mucosa is a critical protective interface between external and internal environments and must serve as a barrier to the myriad microbial species present in this warm, moist environment. The oral cavity is the only area of the body in which hard tissues break through the epithelial surface. The periodontal epithelium surrounding the tooth is specialized to form an attachment and seal around each tooth. This unique function imparts special challenges to the tissue and leads to certain vulnerabilities associated with periodontal disease, especially in view of the continual exposure to the bacterial biofilm (dental plaque) that forms on the tooth surface at the junction of the soft tissue. Thus, this anatomical region is one where there is a significant risk of bacterially induced infection and inflammation.Antimicrobial peptides are important contributors to maintaining the balance between health and disease in this complex environment. These include several salivary antimicrobial peptides, the β-defensins expressed in the epithelium, the α-defensins expressed in neutrophils, and the cathelicidin, LL-37, expressed in both epithelium and neutrophils. These peptides are part of the host innate immune response in this environment. Epithelia, polymorphonuclear leukocytes (neutrophils), and saliva all contribute to the maintaining the health of the oral cavity in overlapping but independent ways. This review will focus on the human oral cavity and include 1) the expression and function of antimicrobial peptides in the oral cavity in the context of innate immune responses, 2) regulation of β-defensins which has led to advances in our understanding of oral epithelial innate immunity, and 3) functional efficacy against oral microbes when it is known. Epithelial antimicrobial peptidesHistorically, the oral epithelium has been considered mainly as a passive covering that becomes damaged and ulcerated in disease. This view has changed dramatically and the epithelial compartment is now seen as providing both...

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Calprotectin in gingival crevicular fluid correlates with clinical and biochemical markers of periodontal disease

Cited by 90 publications

References 27 publications

Gingival Crevicular Fluid Calprotectin, Osteocalcin and Cross-Linked N-Terminal Telopeptid Levels in Health and Different Periodontal Diseases

Gingival Crevicular Fluid Calprotectin, Osteocalcin and Cross-Linked N-Terminal Telopeptid Levels in Health and Different Periodontal Diseases

Effect of Gingival Crevicular Fluid Volume in Smokers

Antimicrobial Peptides in the Oral Environment: Expression and Function in Health and Disease

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