Calprotectin levels in amniotic fluid in relation to intra-amniotic inflammation and infection in women with preterm labor with intact membranes: A retrospective cohort study

Aberšek, Nina; Akouri, Randa; Jonsson, Daniel; Grankvist, Anna; Barman, Malin; Hallingström, Maria; Kacerovský, Marian; Jacobsson, Bo

doi:10.1016/j.ejogrb.2022.03.006

Cited by 1 publication

(2 citation statements)

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“…62 Consistent with its proinflammatory role, previous studies on AF of women with PPROM or PTL have shown that the S100A8/A9 levels significantly increased in patients with MIAC, IAI, or acute HCA com-pared with those of women without these conditions. 28,63 In this study, the plasma S100A8/A9 levels were elevated when MIAC/IAI occurred in pregnancies complicated with PPROM, which agrees with the previous findings in cases of acute HCA complicated with PPROM. 24 Furthermore, we revealed (i) that elevated plasma levels of S100A8/A9…”

Section: Discussionsupporting

confidence: 92%

“…S100A8/A9 (also known as calprotectin) is a heterodimeric protein that plays an important role in the regulation of inflammatory processes through cytokine release and leukocyte recruitment, and is constitutively expressed in monocytes, neutrophils, and macrophages 62 . Consistent with its proinflammatory role, previous studies on AF of women with PPROM or PTL have shown that the S100A8/A9 levels significantly increased in patients with MIAC, IAI, or acute HCA compared with those of women without these conditions 28,63 . In this study, the plasma S100A8/A9 levels were elevated when MIAC/IAI occurred in pregnancies complicated with PPROM, which agrees with the previous findings in cases of acute HCA complicated with PPROM 24 .…”

Section: Discussionsupporting

confidence: 59%

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Potential of plasma inflammatory and angiogenic mediators for predicting spontaneous preterm delivery, intraamniotic infection/inflammation, and composite neonatal morbidity/mortality in women with early preterm premature rupture of membranes

Kim,

Park,

Joo

et al. 2024

American J Rep Immunol

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ProblemTo assess the potential of five inflammatory and six angiogenic/antiangiogenic plasma proteins for predicting imminent spontaneous preterm delivery (SPTD; ≤14 days of sampling), microbial invasion of the amniotic cavity and/or intraamniotic inflammation (MIAC/IAI), and composite neonatal morbidity and mortality (CNMM) in women with early preterm premature rupture of membranes (PPROM).Methods of StudyThis retrospective cohort study included 76 singleton pregnant women with early PPROM (23–30 weeks). Amniotic fluid obtained via amniocentesis was cultured for microorganism detection and assayed for interleukin‐6 to define IAI (≥2.6 ng/mL). Plasma C4a, endoglin, endostatin, IGFBP‐1, IGFBP‐2, MMP‐9, PlGF, S100A8, S100A9, S100 A8/A9, and VEGFR‐1 levels were determined using ELISA.ResultsMultivariate logistic regression analyses revealed significant associations between (i) high levels of plasma S100A8/A9, SPTD ≤14 days after sampling, and shorter sampling‐to‐delivery intervals; (ii) elevated plasma MMP‐9, S100A9, and S100A8/A9 levels and MIAC/IAI, and (iii) decreased plasma endoglin levels and increased CNMM risk, while adjusting for gestational age at sampling (or delivery) and tocolytic use. The area under the curves of the aforementioned proteins ranged from 0.655 to 0.731 for each outcome. Notably, the SPTD risk increased significantly with increasing plasma S100A8/A9 levels (P for trend < .05).ConclusionsPlasma S100A8/A9, MMP‐9, S100A9, and endoglin may represent valuable biomarkers associated with SPTD, MIAC/IAI, and CNMM in women with early PPROM. Owing to their less invasive nature, repeatability, and fair‐to‐moderate diagnostic accuracy, these biomarkers may contribute to risk stratification of PPROM‐related complications in the clinical setting.

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