2010
DOI: 10.3109/02688697.2010.495166
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Calvarial tuberculosis: Uncommon manifestation of common disease – a series of 21 cases

Abstract: Calvarial tuberculosis is endemic in developing countries. This disease mainly affects the young population. With the rising incidence of AIDS, neurosurgeons all over the world are more likely to be exposed to this disease. CT-head and MRI-brain is the mainstay for radiological diagnosis. Definitive diagnosis rests on a biopsy report. Surgical debridement followed by anti-tubercular therapy for 18 months is the mainstay of the management of this unusual presentation.

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Cited by 29 publications
(12 citation statements)
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“…Calvarial TB arises from bacilli seeding from diploic channels, while the balance of virulence and host immune response changes capillary obliteration and granulation begins through fibroblasts (8). Frontal and parietal bones are often affected due to the greater amount of cancellous bone with diploic channels in these bones, however, occipital and spheoid bones are less frequently affected (2,9,10). Dura mater is highly resistant to invasion (5,6).…”
Section: Discussionmentioning
confidence: 99%
“…Calvarial TB arises from bacilli seeding from diploic channels, while the balance of virulence and host immune response changes capillary obliteration and granulation begins through fibroblasts (8). Frontal and parietal bones are often affected due to the greater amount of cancellous bone with diploic channels in these bones, however, occipital and spheoid bones are less frequently affected (2,9,10). Dura mater is highly resistant to invasion (5,6).…”
Section: Discussionmentioning
confidence: 99%
“…[389] The need for surgery in our case was inevitable with an epidural collection causing midline shift and discharging sinus. Most cases in the rural setup present like the reported case.…”
Section: Discussionmentioning
confidence: 99%
“…[10] Primary skull involvement is a rare form of skeletal tuberculosis with few retrospective series offering insights. [389] We report a rare case of primary tuberculous osteomyelitis with epidural abscess causing midline shift and discharging sinus of scalp. The disease progression was arrested with anti-tuberculous therapy, and the patient improved symptomatically.…”
Section: Introductionmentioning
confidence: 99%
“…31 Vertebral compression is usually anteriorly, although posterior cord compression due to tuberculous osteitis in the laminae and pedicles can occur. Epidural tuberculomas can be confused with tumours.…”
Section: Peripheral Radiculopathy/neuropathymentioning
confidence: 98%