Calycosin enhances Treg differentiation for alleviating skin inflammation in atopic dermatitis

Ma, Xin; Deng, Guoshu; Tian, Na; Wang, Hao; Zhao, Hang; Kuai, Le; Luo, Ying; Gao, Chunjie; Ding, Xiaojie; Li, Bin; Li, Bin

doi:10.1016/j.jep.2024.117883

Journal of Ethnopharmacology

2024

DOI: 10.1016/j.jep.2024.117883

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Calycosin enhances Treg differentiation for alleviating skin inflammation in atopic dermatitis

Xin Ma,

Guoshu Deng,

Na Tian

et al.

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Cited by 6 publications

References 37 publications

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Single‐Atom Catalysts with Isolated Cu₁‐N₄ Sites for Atopic Dermatitis Cascade Catalytic Therapy via Activating PPAR Signaling

Kuai,

Huang,

Mao

et al. 2024

Small

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Atopic dermatitis (AD) is one of the most common allergic skin disorders affecting over 230 million people worldwide, while safe and efficient therapeutic options for AD are currently rarely available. Reactive oxygen species (ROS) accumulation plays a key role in AD's disease progression. Therefore, a novel single‐atom catalyst is designed with isolated Cu1‐N4 sites anchored on carbon support (Cu1‐N4 ISAC), featuring triple antioxidant enzyme‐mimicking activities, for efficient AD cascade catalytic therapy (CCT). The excellent superoxide dismutase (SOD)‐, glutathione peroxidase (GPx)‐, and ascorbate peroxidase (APx)‐like activities of Cu1‐N4 ISACs enable the sequential conversion of O2•− to H2O2 and then to harmless H2O, thereby protecting keratinocytes from oxidative stress damage. Notably, two novel experimental methods are developed to directly prove the SOD‐GPx and SOD‐APx cascade catalytic activities for the first time. In vivo experiments show that Cu1‐N4 ISACs are more potent than a recommended typical medicine (halcinonide solution). Additionally, RNA sequencing and bioinformatic analysis reveal that Cu1‐N4 ISACs reduce inflammation and inhibit ROS production by activating PPAR signaling, which is aberrantly reduced in AD. Therefore, the synthesized catalytic medicine offers an alternative to alleviate AD and has the potential to serve as PPAR agonists for treating similar diseases.

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Single‐Atom Catalysts with Isolated Cu₁‐N₄ Sites for Atopic Dermatitis Cascade Catalytic Therapy via Activating PPAR Signaling

Kuai,

Huang,

Mao

et al. 2024

Small

View full text Add to dashboard Cite

show abstract

Exploring the Common Pathogenic Mechanisms of Psoriasis and Atopic Dermatitis: The Interaction between SGK1 and TIGIT Signaling Pathways

Dong,

Lin,

Wang

et al. 2024

Inflammation

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Potential application of matrine microneedles for the treatment of atopic dermatitis in joint skin

Wang,

Shi,

et al. 2025

International Journal of Pharmaceutics

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Calycosin enhances Treg differentiation for alleviating skin inflammation in atopic dermatitis

Cited by 6 publications

References 37 publications

Single‐Atom Catalysts with Isolated Cu₁‐N₄ Sites for Atopic Dermatitis Cascade Catalytic Therapy via Activating PPAR Signaling

Single‐Atom Catalysts with Isolated Cu₁‐N₄ Sites for Atopic Dermatitis Cascade Catalytic Therapy via Activating PPAR Signaling

Exploring the Common Pathogenic Mechanisms of Psoriasis and Atopic Dermatitis: The Interaction between SGK1 and TIGIT Signaling Pathways

Potential application of matrine microneedles for the treatment of atopic dermatitis in joint skin

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About

Calycosin enhances Treg differentiation for alleviating skin inflammation in atopic dermatitis

Cited by 6 publications

References 37 publications

Single‐Atom Catalysts with Isolated Cu1‐N4 Sites for Atopic Dermatitis Cascade Catalytic Therapy via Activating PPAR Signaling

Single‐Atom Catalysts with Isolated Cu1‐N4 Sites for Atopic Dermatitis Cascade Catalytic Therapy via Activating PPAR Signaling

Exploring the Common Pathogenic Mechanisms of Psoriasis and Atopic Dermatitis: The Interaction between SGK1 and TIGIT Signaling Pathways

Potential application of matrine microneedles for the treatment of atopic dermatitis in joint skin

Contact Info

Product

Resources

About

Single‐Atom Catalysts with Isolated Cu₁‐N₄ Sites for Atopic Dermatitis Cascade Catalytic Therapy via Activating PPAR Signaling

Single‐Atom Catalysts with Isolated Cu₁‐N₄ Sites for Atopic Dermatitis Cascade Catalytic Therapy via Activating PPAR Signaling