Calystegines isolated from Ipomoea spp. possibly associated with an ataxia syndrome in cattle in North Western Australia.

Abstract

This paper describes the calystegines isolated from Ipomoea spp., including their chemical structure and characteristics. The possible relationship of these chemicals with the ataxia syndrome in cattle in North western Australia is also discussed.

Convolvulaceae Juss.

“…These Old World species of Ipomoea also produce calystegins similar to those described in Convolvulus arvensis and isolated from Solanum dimidiatum (Dorling et al 2001;Haraguchi et al 2003;Barbosa et al 2006Barbosa et al , 2007Cholich et al 2007Cholich et al , 2009 ). These alkaloids are potent competitive inhibitors of β-glucosidase and α-galactosidase (Molyneux et al 1994(Molyneux et al , 1995Srilatha et al 1997;de Balogh et al 1998;Drager 2004).…”

Identification of Indole Diterpenes in Ipomoea asarifolia and Ipomoea muelleri, Plants Tremorgenic to Livestock

“…Ipomoea species have been reported to cause a neurologic disease with lesions characteristic of a lysosomal storage disease as well as a tremorgenic syndrome with little or no diagnostic lesions in livestock. − Two species, Ipomoea asarifolia and Ipomoea muelleri , members of the Convolvulaceae plant family, are reported to be associated with a tremorgenic syndrome in livestock. , Ipomoea asarifolia has been associated with a tremorgenic syndrome in goats, sheep, and cattle in Northeastern Brazil and the Island of Marajo, − whereas I. muelleri has been reported to cause a similar syndrome in sheep and cattle in Western Australia. − …”

Alpha-mannosidosis in goats caused by the swainsonine-containing plant Ipomoea verbascoidea

“…The occurrence of ataxia in cattle was associated with the presence of different calystegines in Ipomoea spp. 9 In contrast, calystegines B 2 and C 1 showed no inhibition of β-glucosidase in human lymphoblasts, but increased the activity of the enzyme, suggesting that calystegines have little risk of inducing intoxication of livestock. 19 An important observation in I. verbascoidea poisoning was the absence of cytoplasmic vacuolization in nerve and epithelial cells in goats 3, 5 (naturally poisoned), and 9 (experimentally poisoned).…”