CAM/Drug-Induced Hepatotoxicity: Implications in Viral Hepatitis

Parvez, Mohammad K.; Al‐Dosari, Mohammed S.

doi:10.17554/j.issn.2224-3992.2016.05.552

Cited by 2 publications

(3 citation statements)

References 22 publications

(25 reference statements)

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“…Since the first report on the detection of SARS-CoV-2 in the fecal sample of clinically confirmed COVID-19 patients [23], its plausible waterborne transmission through contaminated water has become an important water-based epidemiological issue [19]. Subsequently, ample data on wastewater or sewage surveillance for SARS-CoV-2 has emerged from across the world [24].…”

Section: Quantitative Detection Of Viral Load In Water Samplesmentioning

confidence: 99%

“…Notably, a proportion of SARS-CoV-2-infected patients have also shown gastrointestinal and hepatobiliary manifestations, including fecal shedding of high-titer infectious particles [10][11][12][13][14][15][16][17][18]. In the last two years of the COVID-19 pandemic, there have been a growing number of reports on the worldwide detection of SARS-CoV-2 in wastewater, raw sewage, hospital septic tanks, biological sludge and effluent, lakes, and rivers [19]. In view of the highlighted fecal contamination of water, a potential risk of waterborne transmission of SARS-CoV-2 in countries with poor sanitation and inadequate wastewater management has been envisaged.…”

Section: Introductionmentioning

confidence: 99%

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A Prevalence Risk Analysis of Waterborne Transmission of SARS-CoV-2

2022

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We statistically analyzed 31 published studies comprising 113 water samples collected from 17 countries for SARS-CoV-2 positivity. The pooled estimated prevalence of viral RNA in the tested samples was 64.1% [95% CI:51.6%, 74.9%] with considerable heterogeneity (I2: 90.1%, P<0.001). Notably, wastewater, sewage, hospital septic-tank, biological sludge, and effluent demonstrated statistical significance (P<0.05) for RNA positivity. The country-wise pooled estimated prevalence for Germany, India, Turkey, Spain, the Netherlands, Italy, the USA, and Japan were 88% (76%, 94%), 85% (33%, 98%), 83% (43%, 97%), 78% (54%, 92%), 60% (41%, 77%), 53% (36%, 70%), 53% (27%, 77%), and 25% (13%,43%), respectively. Further subgroup analyses showed that the prevalence of SARS-CoV-2 among the tested water samples was significantly higher in middle-income countries compared to high-income groups. Our data, therefore, suggests wastewater-based epidemiological surveillance as an important tool for community-wide monitoring of SARS-CoV-2. Doi: 10.28991/SciMedJ-2022-04-03-02 Full Text: PDF

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Section: Quantitative Detection Of Viral Load In Water Samplesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Prevalence Risk Analysis of Waterborne Transmission of SARS-CoV-2

2022

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“…In recent decades, several herbal or natural products, mainly the Traditional Chines Medicine (TCM), have become very popular in treating chronic hepatitis B worldwide . However, some of these formulations have been reported to cause liver and other organ toxicity, including serious side effects . Recently, we have reported several medicinal plant extracts and fractions as well as isolation of anti-viral compounds for their novel anti-HBV potential. − …”

Section: Introductionmentioning

confidence: 99%

Novel Anti-Hepatitis B Virus Activity of Euphorbia schimperi and Its Quercetin and Kaempferol Derivatives

et al. 2021

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Natural or plant products, because of their structural diversity, are a potential source for identifying new anti-hepatitis B virus (HBV) agents. Here, we report the anti-HBV activity of Euphorbia schimperi and its quercetin (QRC) and kaempferol derivatives. The anti-HBV-active methanol fraction of E. schimperi was subjected to chromatographic techniques, leading to isolation of three flavonols, following their structure determination by 1 H and 13 C NMR spectroscopies. Their cytotoxicity and anti-HBV potential were assessed using HBV reporter HepG2.2.15 cells, and their modes of action were delineated by molecular docking. The isolated compounds identified as quercetin-3-O-glucuronide (Q3G), quercetin-3-O-rhamnoside (Q3R), and kaempferol-3-O-glucuronide (K3G) were non-cytotoxic to HepG2.2.15 cells. The viral HBsAg/ HBeAg production on day 5 was significantly inhibited by K3G (∼70.2/∼73.4%), Q3G (∼67.8/∼72.1%), and Q3R (∼63.2%/ ∼68.2%) as compared to QRC (∼70.3/∼74.8%) and lamivudine (∼76.5/∼84.5%) used as standards. The observed in vitro anti-HBV potential was strongly supported by in silico analysis, which suggested their structure-based activity via interfering with viral Pol/RT and core proteins. In conclusion, this is the first report on the anti-HBV activity of E. schimperi-derived quercitrin-3-Oglucuronide, quercitrin-3-O-rhamnoside, and kaempferol-3-O-glucuronide, most likely through interfering with HBV proteins.

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CAM/Drug-Induced Hepatotoxicity: Implications in Viral Hepatitis

Cited by 2 publications

References 22 publications

A Prevalence Risk Analysis of Waterborne Transmission of SARS-CoV-2

A Prevalence Risk Analysis of Waterborne Transmission of SARS-CoV-2

Novel Anti-Hepatitis B Virus Activity of Euphorbia schimperi and Its Quercetin and Kaempferol Derivatives

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