Cambendazole Toxicity in Calves

Abstract

The death of 3 of 8 dairy calves was associated with the administration of 98.5 mg/kg cambendazole. Significant lesions consisted of marked pleural effusion, severe pulmonary oedema and necrotic lymphadenopathy.

Review of methodology for the determination of benzimidazole residues in biological matrices

“…Seiler observed anaemia in dogs after prolonged treatment with TBZ [50]. In calves, treatment with cambendazole caused pulmonary oedema and necrotic lymphadenopathy, which was fatal in some cases [51].…”

Eryngial (trans-2-dodecenal), a bioactive compound fromEryngium foetidum: its identification, chemical isolation, characterization and comparison with ivermectinin vitro

“…Mebendazole [methyl 5-benzoyl-2-benzimidazole carbamate] (Vermox; Janssen) was reported to be inactive against the infective larvae in immunosuppressed dogs, and has little effect on the parasite in muscle tissue of mice (Grove, 1982 a ). Use of cambendazole ([5-isopropoxycarbonylamino-2-(4-thiazyl) benzimidazole] (Merck, Sharp & Dohme) has been banned as a result of its linkage to several fatal idiosyncratic reactions in cattle (Hogg, 1978; Main and Vass, 1980).…”

“…Mebendazole [methyl 5-benzoyl-2-benzimidazole carbamate] (Vermox; Janssen) was reported to be inactive against the infective larvae in immunosuppressed dogs, and has little effect on the parasite in muscle tissue of mice (Grove, 1982a). Use of cambendazole ([5-isopropoxycarbonylamino-2-(4thiazyl) benzimidazole] (Merck, Sharp & Dohme) has been banned as a result of its linkage to several fatal idiosyncratic reactions in cattle (Hogg, 1978;Main and Vass, 1980). Alternatively, ivermectin [22,23-dihydroavermectin B 1 ] (Merck, Sharp & Dohme), a broad-spectrum, commercial drug (Fisher, 1985;Grove, 1989) that is a synthetic, lipophilic, macrocyclic lactone (Gustafsson et al 1987;Campbell, 1989), bears promise as an efficacious treatment against strongyloidosis (Naquira et al 1989;Marti et al 1996).…”