Cambios en la resonancia magnética cerebral asociados al síndrome de fibromialgia

Effects of 24-Week Exergame Intervention on the Gray Matter Volume of Different Brain Structures in Women with Fibromyalgia: A Single-Blind, Randomized Controlled Trial

“…Preprocessing data include the following steps: (1) motion correction and averaging [50]; (2) removal of nonbrain tissue [51]; (3) automated Talairach transformation [52]; (4) segmentation of subcortical white matter and deep gray matter structures [53]; (5) intensity normalization [54]; (6) tessellation of the gray matter and white matter boundary [55]; (7) topology correction; (8) surface deformation following intensity gradients to reconstruction [53]. Structures that are part of the "pain matrix" (left and right regions of the hippocampus, insula, thalamus, amygdala, and cerebellum, in addition to total gray matter) and have an interest in the study of FM [56,57] were selected.…”

Impact of Fibromyalgia in the Hippocampal Subfields Volumes of Women—An MRI Study

“…Previous research has reported central nervous system (CNS) abnormalities in people with FM [10], including functional, metabolic, and structural alterations in brain regions involved in pain processing [11][12][13][14][15][16]. Besides, alterations in the immune system, sleep patterns, fatigue, and moods contributed to pain and dysfunction in people with FM.…”

“…The hippocampus is one of the most studied brain structures that play an important role in numerous processes, including memory, navigation, cognition, moods, stress, and pain [23][24][25][26] related to FM symptomatology. A previous review focused on FM showed alterations in the volume and metabolite levels of the hippocampus [12]. This region is composed of a series of sub-regions such as the subiculum, the dentate gyrus and cornus ammonis [27] among others.…”

Tratamiento de la fibromialgia en pacientes con afectación emocional durante programas cognitivo-conductuales y sin componente de expresión de las emociones a través del dibujo

“…En una reciente revisión sobre el tema (Murga et al, 2017) se concluye que los principales hallazgos son cambios en el volumen en hipocampo, ínsula, corteza prefrontal y corteza cingular y cambios en los niveles de Nacetilaspartato, colina y glutamato, entre otros metabolitos. Sin embargo, estos hallazgos son inespecíficos y comunes a otros cuadros de dolor crónico (Murga et al, 2017).…”

“…Esta región junto con la corteza prefrontal interviene en los procesos de inhibición y facilitación del dolor, por lo que ambas estructuras influyen en la modulación del dolor. Los cambios estructurales en estos sistemas podrían contribuir al mantenimiento y cronificación del dolor tanto en la fibromialgia como en otros síndromes de dolor crónico (Murga et al, 2017).…”