Cambios en las características clínicas y desenlaces de pacientes hospitalizados por COVID-19 durante dos años de pandemia: experiencia en un hospital venezolano

Arvelo, María C.; de, María Montes; Sánchez-Traslaviña, Laura; Pujol, Flor H.; Jaspe, Rossana C.; Silva, Isabel C.; Stulin, Irene; Quevedo, Jennireth; Valera, Nathalia; Papa, Irene; Bacci, Santiago; Abreu, Fátima De; Villaroel, Héctor; Catari, Juan C.; Lopez, José L.; Moran, Brigitte; Cárdenas, Claudio; Santucci, Saverio; Viloria, José L.; García, Eleonora; Gómez, Jerry; Martinelli, Antonio; Guzmán, Manuel

doi:10.17843/rpmesp.2022.393.11195

Cited by 3 publications

(3 citation statements)

References 27 publications

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“…A higher representation of healthcare workers was noted in the vaccinated group, likely attributable to this demographic being prioritized for vaccination in accordance with WHO and PAHO guidelines for risk groups [32,39]. Both the vaccinated and unvaccinated cohorts had comparable characteristics in terms of sex, age, and comorbidities, with the exception of bronchial asthma.…”

Section: Discussionmentioning

confidence: 99%

COVID-19 Vaccination and Lethality Reduction: A Prospective Cohort Study in Venezuela

Forero-Peña,

Leyva,

Valenzuela

et al. 2024

Preprint

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Background While rigorous randomized clinical trials have substantiated the efficacy of COVID-19 vaccines in reducing hospitalization and mortality rates, there is a paucity of post-authorization analyses conducted in real-world settings. In Venezuela, the primary vaccines administered are BBIBP-CorV (Sinopharm) and Gam-COVID-Vac (Sputnik-V). However, the performance and effectiveness of these vaccines within this specific population remain to be thoroughly investigated. Methods A prospective cohort study was undertaken from October 5, 2021, to March 31, 2022, across four sentinel hospitals in Venezuela. The outcomes were evaluated at two time points: day 28 and day 48, utilizing the WHO’s COVID-19 Clinical Progression Scale. For the purpose of analysis, patients were classified into two groups: vaccinated and unvaccinated. Results The study included a total of 175 patients, of which 85 (48.6%) were categorized as vaccinated, with the majority (76.5%) having received two doses. The median age of the patients was 68 years, with a slight predominance of females (53.1%), and the majority being unemployed/retired (60.6%). Hypertension (53.1%) and diabetes (18.3%) were the most prevalent comorbidities. The median Charlson index of the patients was 3 points, with no statistically significant differences observed between the groups (p = 0.2). Upon admission, dyspnea was more commonly observed in unvaccinated patients compared to vaccinated patients (76.7% vs. 62.4%, p = 0.039). Almost all laboratory parameters were comparable in both groups, with the exception of the median D-dimer level, which was significantly higher in unvaccinated patients (7.6 vs. 1.4 µg/mL, p = 0.015). A total of 50 patients (28.6%) died of the disease, with a higher proportion of deaths observed in unvaccinated patients compared to vaccinated patients (35.6% vs. 21.2%, p = 0.035). Factors such as advanced age (OR = 1.043, 95%CI = 1.015–1.071, p = 0.002) were associated with increased odds of death, while factors such as vaccination against COVID-19 (OR = 0.428, 95%CI = 0.185–0.99, p = 0.047), high oxygen saturation (OR = 0.964, 95%CI = 0.934–0.995, p = 0.024), and enoxaparin administration (OR = 0.292, 95%CI = 0.093–0.917, p = 0.035) were associated with decreased odds of death. Conclusion In the course of the third and fourth waves of the pandemic, vaccination against COVID-19 was found to be associated with a 57% reduction in lethality among patients treated in four public hospitals in Venezuela.

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Section: Discussionmentioning

confidence: 99%

COVID-19 Vaccination and Lethality Reduction: A Prospective Cohort Study in Venezuela

Forero-Peña,

Leyva,

Valenzuela

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…A higher representation of healthcare workers was noted in the vaccinated group, likely attributable to this demographic being prioritized for vaccination in accordance with WHO and PAHO guidelines for risk groups [33,38]. Both the vaccinated and unvaccinated cohorts had comparable characteristics in terms of sex, age, and comorbidities, with the exception of bronchial asthma.…”

Section: Discussionmentioning

confidence: 99%

“…The diagnosis of SARS-CoV-2 infection was con rmed via antigen testing and reverse transcription polymerase chain reaction (RT-PCR) [32] at the "Rafael Rangel" National Institute of Hygiene (Venezuela). The study period included cases from the third (June to December 2021) and fourth (January to February 2022) waves of the pandemic in Venezuela [33], each characterized by different variants of SARS-CoV-2. A national genomic surveillance study analyzed samples from nasopharyngeal or nasal swabs con rmed positive by RT-PCR during routine COVID-19 diagnosis in Venezuela.…”

Section: Study Design and Populationmentioning

confidence: 99%

COVID-19 Vaccination and Mortality Reduction: A Prospective Cohort Study in Venezuela

Forero-Peña,

Leyva,

Valenzuela

et al. 2023

Preprint

View full text Add to dashboard Cite

Background While rigorous randomized clinical trials have substantiated the efficacy of COVID-19 vaccines in reducing hospitalization and mortality rates, there is a paucity of post-authorization analyses conducted in real-world settings. In Venezuela, the primary vaccines administered are Sinopharm and Sputnik-V. However, the performance and effectiveness of these vaccines within this specific population remain to be thoroughly investigated. Methods A prospective cohort study was undertaken from October 5, 2021, to March 31, 2022, across four sentinel hospitals in Venezuela. The outcomes were evaluated at two time points: day 28 and day 48, utilizing the WHO’s COVID-19 Clinical Progression Scale. For the purpose of analysis, patients were classified into two groups: vaccinated and unvaccinated. Results The study included a total of 175 patients, of which 85 (48.6%) were categorized as vaccinated, with the majority (76.5%) having received two doses. The median age of the patients was 68 years, with a slight predominance of females (53.1%), and the majority being unemployed/retired (60.6%). Hypertension (53.1%) and diabetes (18.3%) were the most prevalent comorbidities. The median Charlson index of the patients was 3 points, with no statistically significant differences observed between the groups (p = 0.2). Upon admission, dyspnea was more commonly observed in unvaccinated patients compared to vaccinated patients (76.7% vs. 62.4%, p = 0.039). Almost all laboratory parameters were comparable in both groups, with the exception of the median D-dimer level, which was significantly higher in unvaccinated patients (7.6 vs. 1.4 µg/mL, p = 0.015). A total of 50 patients (28.6%) died of the disease, with a higher proportion of deaths observed in unvaccinated patients compared to vaccinated patients (35.6% vs. 21.2%, p = 0.035). Factors such as advanced age (OR = 1.043, 95%CI = 1.015–1.071, p = 0.002) were associated with increased odds of death, while factors such as vaccination against COVID-19 (OR = 0.428, 95%CI = 0.185–0.99, p = 0.047), high oxygen saturation (OR = 0.964, 95%CI = 0.934–0.995, p = 0.024), and enoxaparin administration (OR = 0.292, 95%CI = 0.093–0.917, p = 0.035) were associated with decreased odds of death. Conclusion In the course of the third and fourth waves of the pandemic, vaccination against COVID-19 was found to be associated with a 57% reduction in mortality among patients treated in four public hospitals in Venezuela.

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COVID-19 vaccination and lethality reduction: a prospective observational study in Venezuela during the last two waves

Forero-Peña,

Leyva,

Valenzuela

et al. 2024

Discov Public Health

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Background In Venezuela, the predominant vaccines administered are BBIBP-CorV and Gam-COVID-Vac. Despite robust evidence from randomized clinical trials validating the effectiveness of COVID-19 vaccines in mitigating hospitalization and mortality, there is still a lack of post-authorization safety studies conducted within this demographic population. Methods A prospective observational study from October 5, 2021 to March 31, 2022 encompassed COVID-19 vaccinated and unvaccinated patients from four sentinel hospitals in Venezuela. Patient lethality was predicted using Charlson Comorbidity index. Clinical outcomes were assessed through WHO’s COVID-19 Clinical Progression Scale. Results Out of the 175 patients assessed, 85 (48.6%) were vaccinated. The median Charlson Comorbidity index was 3 points, with no statistically significant differences observed between the groups (p = 0.2). A total of 50 (28.6%) patients died during the study period, with higher proportion of deaths in unvaccinated patients (35.6% vs. 21.2%, p = 0.035). Advanced age (OR = 1.043, 95% CI = 1.015–1.071, p = 0.002) was associated with increased death risk, whereas vaccination against COVID-19 (OR = 0.428, 95% CI = 0.185–0.99, p = 0.047), high oxygen saturation (OR = 0.964, 95% CI = 0.934–0.995, p = 0.024), and enoxaparin administration (OR = 0.292, 95% CI = 0.093–0.917, p = 0.035) were associated with decreased death risk. Conclusion During the third and fourth waves of the pandemic, COVID-19 vaccination was associated with a 57% reduction in lethality among patients in four public hospitals in Venezuela.

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Cambios en las características clínicas y desenlaces de pacientes hospitalizados por COVID-19 durante dos años de pandemia: experiencia en un hospital venezolano

Cited by 3 publications

References 27 publications

COVID-19 Vaccination and Lethality Reduction: A Prospective Cohort Study in Venezuela

COVID-19 Vaccination and Lethality Reduction: A Prospective Cohort Study in Venezuela

COVID-19 Vaccination and Mortality Reduction: A Prospective Cohort Study in Venezuela

COVID-19 vaccination and lethality reduction: a prospective observational study in Venezuela during the last two waves

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