Cambios en los niveles de factor de crecimiento nervioso con el envejecimiento y el tratamiento neurotrófico en primates no humanos

Lorigados, Lourdes; Pavón, Nancy; Serrano, Teresa; Ma, Robinson; Ci, Fernández; Alvarez, P

doi:10.33588/rn.3305.2001185

Cited by 2 publications

(1 citation statement)

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“…Interestingly, sortilin exhibits the highest accumulation with ongoing development of the forebrain (Hermans-Borgmeyer et al 1999). Some results support the idea that NTs are promising candidates for improving remyelination and thus ameliorating MS. A critical point for making a treatment with neurotrophins effective is the need to achieve a local concentration in a range of 1-10 ng/ml, which is way beyond the endogenous level (pg range; Lorigados et al 2001). Several possibilities exist to circumvent the bloodbrain barrier, which is impermeable for NTs under normal conditions (Althaus 2004;Blesch 2006).…”

Section: Resultsmentioning

confidence: 99%

Oligodendroglial Cells and Neurotrophins: A Polyphonic Cantata in Major and Minor

et al. 2008

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Oligodendrocytes met neurotrophins in the early 1990s of the last century. Since then, their relationship underwent functional ups and downs partially dependent on the developmental stage of the oligodendroglial cells and the species, from which the cells were derived. This review provides a brief overview of oligodendroglial cells and neurotrophins, characterizes neurotrophin signaling during oligodendroglial development, and discusses the significance of proneurotrophins and sortilin for oligodendroglial death and survival. Furthermore, data are provided that TrkA, the tyrosine kinase competent NGF receptor, is localized to caveolincontaining microdomains on the oligodendroglial plasma membrane; an interplay of caveolin and NGF signaling via TrkA might be of functional importance. Finally, experimental evidence of studies is presented which support the idea that neurotrophins are promising candidates for improving oligodendroglial regeneration and remyelination.

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