Camel milk lactoferrin reduces the proliferation of colorectal cancer cells and exerts antioxidant and DNA damage inhibitory activities

Habib, Hosam M.; Ibrahim, Wissam H.; Schneider‐Stock, Regine; Hassan, Hassan M.A.

doi:10.1016/j.foodchem.2013.03.039

Cited by 150 publications

(113 citation statements)

References 15 publications

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“…It is demonstrated that the potential for camel lactoferrin to inhibit HCV entry into human leukocytes is with more efficiency than human or bovine lactoferrin [31]. The potential of camel milk lactoferrin for its ability to inhibit the proliferation of the colon cancer cell line has been reported [42]. The concentration of lysozyme, lactoferrin and immunoglobulins in camel milk is higher than in bovine or buffalo milk [30,68].…”

Section: Antibacterial Activitymentioning

confidence: 99%

“…It is known to have a therapeutic potential against many diseases including cancer [42]. It has long been utilized for its beneficial effect in broad range of disease conditions, such as insulin-dependent diabetes mellitus (IDDM) [6], infant diarrhea [121], hepatitis [24,30], allergy [105], lactose intolerance [28], autism [104] and alcohol-induced liver damage [8].…”

Section: Introductionmentioning

confidence: 99%

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Camel Milk: An Important Natural Adjuvant

et al. 2017

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One humped camel (Camelus dromedarius) breeds, indigenous to India, have been shown to have good genetic potential to produce milk. Camel milk not only is cost-effective in terms of feed conversion but also has additional advantage of longer lactation period and unique adaptation mechanisms for warm arid and semiarid regions. The key features of camel milk in comparison with other milk are low fat with high content of unsaturated and long-chain fatty acid. The proteins are rich in lactoferrin and lysozymes, but deficient in b-lactoglobulin. It has higher percentage of total salts, free calcium, protective proteins and vitamin C, and some of the microminerals, viz iron, copper and zinc. Physicochemical properties of camel milk are also unique and useful for food processing. The shelf life of raw camel milk is 8-9 h, which can be extended up to 18-20 h through activation of camel lactoperoxidase system. Heat stability of camel milk is shown to be highest at pH 6.8, and it ferments relatively slowly compared to the cattle milk. The camel milk is successfully processed for producing a variety of products, such as fermented milk ('lassi'), soft cheese, flavored milk and 'kulfee' (a kind of ice cream). Camel milk has been traditionally used in different regions of the world as natural adjuvant for managing a variety of human diseases.

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Section: Antibacterial Activitymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Camel Milk: An Important Natural Adjuvant

et al. 2017

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“…Both camel milk and urine are among natural products endowed in agents with such desirable characteristics. These products possess supreme cytotoxic effect against various cancer cells and cell lines (Table 1) [9][10][11]16,23,[36][37][38][39][40][41][42][43][44][45][46][47][48][49][50][51].…”

Section: Cytotoxic Effectmentioning

confidence: 99%

“…Meanwhile, camel's milk and urine are able to increase the expression of chemo-protective genes, Nqo1 and Gsta1 mRNA levels pertaining to increase the levels of several antioxidant enzymes which prevent the formation of highly reactive oxygen radicals and then protect DNA adduct and cell damage [23,38,56]. In addition, over expression of Nqo1 in several human solid tumors and cancer cells is shown to activate bio-reductive chemotherapeutic agents in tumor cells that allow tumor cytotoxicity without corresponding toxicity to normal cells [57].…”

Section: Cytotoxic Effectmentioning

confidence: 99%

Therapeutic Applications of Camel’s Milk and Urine against Cancer: Current Development Efforts and Future Perspectives

Alebie¹,

Yohannes²,

Worku³

2017

J Cancer Sci Ther

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“…These proteins are among the main sources of bioactive peptides, which are generally latent within the sequence of food proteins (Clare and Swaisgood 2000). When these peptides are released, either during the food processing (by enzymatic hydrolysis or fermentation) or during the gastrointestinal digestion from parent proteins, they may exhibit important biological functions such as antioxidant, antimicrobial (Salami et al 2010), antihypertensive (Quan et al 2008), opioid (Shabo and Yagil 2005), mineral binding (Gorban and Izzeldin 1997), hypocholesterolemic (Ali et al 2013), immunemodulatory (Takeda et al 2011), and anti-proliferative activities (Habib et al 2013).…”

Section: Introductionmentioning

confidence: 99%

ACE- inhibitory and radical scavenging activities of bioactive peptides obtained from camel milk casein hydrolysis with proteinase K

Rahimi

Ghaffari

Salami

et al. 2016

Dairy Sci. & Technol.

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The aim of this study was to evaluate the effects of enzymatic hydrolysis of camel whole casein on their antioxidant and angiotensin-converting enzyme (ACE)-inhibitory properties. Whole camel casein was hydrolyzed by proteinase K (PK), and the hydrolysates were fractionized by ultrafiltration membranes into three fractions. Semi-preparative reversed-phase high-performance liquid chromatography (RP-HPLC) was used to differentiate the mixture of peptides in the 3 kDa permeate fractions. A fraction (F4) with potentials of ACE-inhibitory activity (IC50 = 73 μg.mL −1 ) and radical scavenging activity (IC50 = 6.8 μg.mL −1 ) was selected for further purification and fractionation. The fraction F4C obtained from a second step purification of F4 showed strong ACE-inhibitory activity (IC 50 = 36 μg.mL −1 ) as well as radical scavenging activity (IC 50 = 3.3 μg.mL −1 ). The results of this study suggest that whole camel casein can be considered as a promising source for the production of peptides with potential of ACE-inhibitory and antioxidant activities.

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Camel milk lactoferrin reduces the proliferation of colorectal cancer cells and exerts antioxidant and DNA damage inhibitory activities

Cited by 150 publications

References 15 publications

Camel Milk: An Important Natural Adjuvant

Camel Milk: An Important Natural Adjuvant

Therapeutic Applications of Camel’s Milk and Urine against Cancer: Current Development Efforts and Future Perspectives

ACE- inhibitory and radical scavenging activities of bioactive peptides obtained from camel milk casein hydrolysis with proteinase K

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