A study was conducted to estimate the effect of UV-C (200-280 nm) radiation stress on growth and physiochemical responses of Camelina sativa L. cv. Calina (EC643910; a potential bio-fuel crop) for its possible mass multiplication at high-altitude under high radiations. The germination percentage in terms of radicle protrusion and opening of cotyledonary leaves significantly decreased 13.98 and 27.8 %, respectively, as compared to control. However, no significant change was observed in growth parameters including root and shoot lengths and fresh biomass. The relative membrane leakage rate and lipid peroxidation as a malondialdehyde contents significantly increased with the value of *99 % and 0.17 mM g -1 FW, respectively, under UV-C stress. Also, the proline, glycine betaine and total soluble sugars contents increased by *330, *440, *144 %, respectively, as compared to control. Among non-enzymatic antioxidants, the ascorbic acid and total phenol contents significantly increased by *284 and *537 %, respectively, as compared to control. Likewise, the activity of antioxidant enzyme, ascorbate peroxidase, guaiacol peroxidase and catalase increased under UV-C stress with the value of 1.03, 0.05 and 0.06 lmol mg protein -1 min -1 , respectively. In addition, the chlorophyll a, b and total (a ? b) contents decreased by *180, *151 and *147 %, respectively, as compared to control. In contrast, the total carotenoids and anthocyanin contents increased by *160 and *184 %, respectively. Our findings suggest the adaptive growth and physiochemical responses of C. sativa under UV-C stress. Therefore, it may be recommended for large-scale cultivation at high-altitude under intense natural radiations for future bio-fuel production.