Camellia sinensis (L.) Kuntze Extract Attenuates Ovalbumin-Induced Allergic Asthma by Regulating Airway Inflammation and Mucus Hypersecretion

Kang, Sohi; Kim, Hyun-Yong; Lee, A Yeong; Kim, Hyo Seon; Park, Jun Hong; Moon, Byeong Cheol; Nam, Hyeon Hwa; Chae, Sung-Wook; Jung, Bokyung; Moon, Changjong; Shin, In Sik; Kim, Joong Sun; Seo, Yun-Soo

doi:10.3390/pharmaceutics15092355

Cited by 3 publications

(2 citation statements)

References 61 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ineterleukin-4 (IL-4) levels in the BALF were measured using enzyme-linked immunosorbent assay (ELISA) kits (Mouse IL-4 DuoSet ELISA, DY404-05; R&D Systems, Minneapolis, MN, USA), following the manufacturer’s instructions. Total and OVA-specific IgE in the BALF were quantified using ELISA kits (Mouse IgE ELISA Kit, ab157718, Abcam, Cambridge, UK; LEGEND MAX™ Mouse OVA Specific IgE ELISA Kit, BioLegend, San Diego, CA, USA) [ 45 ].…”

Section: Methodsmentioning

confidence: 99%

An Integrative Study of Scrophularia takesimensis Nakai in an Ovalbumin-Induced Murine Model of Asthma: The Effect on T Helper 2 Cell Activation

Seo,

Song,

Kim

et al. 2024

Pharmaceutics

Self Cite

View full text Add to dashboard Cite

Scrophularia have traditionally been used as herbal medicines to treat neuritis, sore throats, and laryngitis. In particular, S. takesimensis, a Korean endemic species with restricted distribution on Ulleung Island, holds significant resource and genetic value. However, its pharmacological properties have not been thoroughly evaluated. Thus, we provide detailed morphological characteristics and genomic information for S. takesimensis in this study. Moreover, its pharmacological activity was evaluated in an ovalbumin-induced asthma rat model, using extracts of S. takesimensis roots (100 or 200 mg/kg). The distinguishing features of S. takesimensis from related species include the presence or absence of stem wings, leaf shape, and habitat. The chloroplast (cp) genome of this species is 152,420 bp long and exhibits a conserved quadripartite structure. A total of 114 genes were identified, which included 80 protein-coding genes, 30 transfer RNA (tRNA) genes, and 4 ribosomal RNA (rRNA) genes. The gene order, content, and orientation of the S. takesimensis cp genome was highly conserved and consistent with the general structure observed in S. buergeriana and S. ningpoensis cp genomes. Confirming the anti-inflammatory effects of S. takesimensis extract (STE) using an established mouse model of ovalbumin-induced asthma, we observed reduced asthmatic phenotypes, including inflammatory cell infiltration, mucus production, and suppression of T helper 2 (Th2) cell. Furthermore, STE treatment reduced Th2 cell activation and differentiation. This study underscores the medicinal value of S. takesimensis. The importance of preserving S. takesimensis was revealed and crucial insights were provided for further research on its utilization as a medicinal resource.

show abstract

Section: Methodsmentioning

confidence: 99%

An Integrative Study of Scrophularia takesimensis Nakai in an Ovalbumin-Induced Murine Model of Asthma: The Effect on T Helper 2 Cell Activation

Seo,

Song,

Kim

et al. 2024

Pharmaceutics

Self Cite

View full text Add to dashboard Cite

show abstract

“…In addition, there is evidence that certain compounds like quercetin, kaempferol, resveratrol, phlorotannins, and saponins can help reduce allergic reactions by lowering the expression of the FcεRI receptor. This receptor is essential for the long-term sensitization of mast cells and their degranulation during the effector phase [179][180][181][182][183]. Anthocyanidins Food allergy 1 and 5 mg/mL of wild blueberry extract Caco-2 cells (in vitro)…”

Section: Actions On the Immune Systemmentioning

confidence: 99%

Dietary Polyphenols, Plant Metabolites, and Allergic Disorders: A Comprehensive Review

Farhan,

Rizvi,

Aatif

et al. 2024

Pharmaceuticals

View full text Add to dashboard Cite

Given the ongoing rise in the occurrence of allergic disorders, alterations in dietary patterns have been proposed as a possible factor contributing to the emergence and progression of these conditions. Currently, there is a significant focus on the development of dietary therapies that utilize natural compounds possessing anti-allergy properties. Dietary polyphenols and plant metabolites have been intensively researched due to their well-documented anti-inflammatory, antioxidant, and immunomodulatory characteristics, making them one of the most prominent natural bioactive chemicals. This study seeks to discuss the in-depth mechanisms by which these molecules may exert anti-allergic effects, namely through their capacity to diminish the allergenicity of proteins, modulate immune responses, and modify the composition of the gut microbiota. However, further investigation is required to fully understand these effects. This paper examines the existing evidence from experimental and clinical studies that supports the idea that different polyphenols, such as catechins, resveratrol, curcumin, quercetin, and others, can reduce allergic inflammation, relieve symptoms of food allergy, asthma, atopic dermatitis, and allergic rhinitis, and prevent the progression of the allergic immune response. In summary, dietary polyphenols and plant metabolites possess significant anti-allergic properties and can be utilized for developing both preventative and therapeutic strategies for targeting allergic conditions. The paper also discusses the constraints in investigating and broad usage of polyphenols, as well as potential avenues for future research.

show abstract

An Updated Comprehensive Review of Plants and Herbal Compounds with Antiasthmatic Effect

Rajizadeh,

Najafipour,

Bejeshk

2024

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Background. Asthma is a common disease with rising prevalence worldwide, especially in industrialized countries. Current asthma therapy with traditional medicines lacks satisfactory success, hence the patients’ search for alternative and complementary treatments for their diseases. Researchers have conducted many studies on plants with antiallergic and antiasthmatic effects in recent decades. Many of these plants are now used in clinics, and searching for their mechanism of action may result in creating new ideas for producing more effective drugs. Purpose. The goal of this review was to provide a compilation of the findings on plants and their active agents with experimentally confirmed antiasthmatic effects. Study Design and Method. A literature search was conducted from 1986 to November 2023 in Scopus, Springer Link, EMBASE, Science Direct, PubMed, Google Scholar, and Web of Science to identify and report the accumulated knowledge on herbs and their compounds that may be effective in asthma treatment. Results. The results revealed that 58 plants and 32 herbal extracted compounds had antiasthmatic activity. Also, 32 plants were shown to have anti-inflammatory and antioxidative effects or may act as bronchodilators and potentially have antiasthmatic effects, which must be investigated in future studies. Conclusion. The ability of herbal medicine to improve asthma symptoms has been confirmed by clinical and preclinical studies, and such compounds may be used as a source for developing new antiasthmatic drugs. Moreover, this review suggests that many bioactive compounds have therapeutic potential against asthma.

show abstract

Camellia sinensis (L.) Kuntze Extract Attenuates Ovalbumin-Induced Allergic Asthma by Regulating Airway Inflammation and Mucus Hypersecretion

Cited by 3 publications

References 61 publications

An Integrative Study of Scrophularia takesimensis Nakai in an Ovalbumin-Induced Murine Model of Asthma: The Effect on T Helper 2 Cell Activation

An Integrative Study of Scrophularia takesimensis Nakai in an Ovalbumin-Induced Murine Model of Asthma: The Effect on T Helper 2 Cell Activation

Dietary Polyphenols, Plant Metabolites, and Allergic Disorders: A Comprehensive Review

An Updated Comprehensive Review of Plants and Herbal Compounds with Antiasthmatic Effect

Contact Info

Product

Resources

About