Camphor elicits up-regulation of hepatic and pulmonary pro-inflammatory cytokines and chemokines via activation of NF-kB in rats

Somade, Oluwatobi T.; Ajayi, Babajide O.; Tajudeen, Nurudeen O.; Atunlute, Eniola M.; James, Adewale Segun; Kehinde, Samuel Abiodun

doi:10.1016/j.pathophys.2019.07.005

Cited by 23 publications

(8 citation statements)

References 55 publications

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“…In our previous study, we reported that administration of methyl cellosolve significantly increase the renal levels of inflammatory cytokines after 7, 14 and 21 days of administration in rats [ 46 ]. Also administration of camphor was reported to increase the hepatic expressions of pro-inflammatory cytokines (TNF-α, IL-1β, and IL-6) and two chemokines called regulated upon activation normal T cell expressed and secreted (RANTES), and monocyte chemo-attractant protein 1 (MCP-1) in a dose dependent manner in rats [ 47 ].…”

Section: Discussionmentioning

confidence: 99%

Hepatic oxidative stress, up-regulation of pro-inflammatory cytokines, apoptotic and oncogenic markers following 2-methoxyethanol administrations in rats

Somade

Ajayi

Olunaike

et al. 2020

Biochemistry and Biophysics Reports

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2-methoxyethanol (2-ME) is an organic solvent widely used in the manufacture of brake fluids, paints, resins, varnish, nail polish, acetate cellulose, wood coloring, and as a plasticizer in plastics manufacturing. We therefore, investigated its effect on the liver, in a time-course study in male Wistar rats. Animals were orally administered 50 mg/kg body weight of 2-ME for a period of 7, 14, and 21 days. Following 7 days of administration of 2-ME, there was a significant increase in the level of Bax, c-Myc, K-Ras, TNF-α, IL-1β, IL-6, MDA and GPx activity, while the levels of Bcl-2, NO and GSH were significantly reduced compared with control. At the end of 14 days exposure, Bcl-2, and GSH levels, as well as GST activity, were significantly decreased, while levels of Bax, c-Myc, K-Ras, caspase-3, TNF-α, IL-1β, IL-6, MDA and NO were significantly increased compared with control. After 21 days of 2-ME administration, Bcl-2, IL-10, and GSH levels, as well as SOD and GST activities, were significantly decreased, while levels of Bax, c-Myc, K-Ras, caspase-3, p53, TNF-α, IL-1β, IL-6, MDA and NO were significantly increased compared with control. Lastly, liver histopathology confirmed and corroborated the biochemical findings reported above. We therefore, advised that exposures to 2-ME should be strictly avoided as it could trigger hepatic damage through the disorganization of the antioxidant system, up-regulation of inflammatory, apoptotic, and oncogenic markers in rats.

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Section: Discussionmentioning

confidence: 99%

Hepatic oxidative stress, up-regulation of pro-inflammatory cytokines, apoptotic and oncogenic markers following 2-methoxyethanol administrations in rats

Somade

Ajayi

Olunaike

et al. 2020

Biochemistry and Biophysics Reports

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“…Thus, we examined the effect of Sal-miR-58 on nuclear factor kB (NF-kB) p65 and p50, which play an essential role in the inflammatory response through regulation of genes encoding inflammatory cytokines (interleukin 1b [IL-1b], tumor necrosis factor a [TNF-a], IL-6). 21,22 The results showed that the expression levels of NF-kB p65 and p50 in the aortas of Ang IIinfused ApoE À/À mice were significantly higher than those in control mice, while Sal-miR-58 treatment significantly reduced the expression of NF-kB p65 and p50 ( Figure 1H). Consistently, compared with Ang II-infused ApoE À/À mice, the serum levels of inflammatory factors IL-1b, IL-6, and TNF-a also declined significantly after Sal-miR-58 administration to Ang II-infused ApoE À/À mice, as detected by ELISA ( Figure 1I).…”

Section: Synthetic Sal-mir-58 Induces Vsmc Autophagy and Inhibits Thementioning

confidence: 97%

Salvia miltiorrhiza-Derived Sal-miR-58 Induces Autophagy and Attenuates Inflammation in Vascular Smooth Muscle Cells

Qin

Zheng

Yang

et al. 2020

Molecular Therapy - Nucleic Acids

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“…During hyperglycemia-mediated oxidative stress, high levels of ROS lead to endothelial dysfunctions by damaging DNA, proteins, lipids, and by deregulating NO production and the redox sensitive transcription factor, nuclear factor erythroid 2-related factor 2 (Nrf2), which regulates the expression of genes encoding redox enzymes [ 10 , 17 , 18 , 19 , 20 , 21 ]. Furthermore, high glucose-induced oxidative stress activates the nuclear translocation of the nuclear factor kappa B (NFκB) transcriptional factor that induces the production of pro-inflammatory cytokines, such as interleukin-6 (IL-6) [ 22 ]. Conversely, hyperglycemia-caused redox changes may inhibit AMP-activated protein kinase (AMPK) signaling pathway, which exerts anti-inflammatory effects and acts as a key regulator of the endothelial function through induction of eNOS activity and NO vasodilator production [ 23 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

Medicinal Plant Polyphenols Attenuate Oxidative Stress and Improve Inflammatory and Vasoactive Markers in Cerebral Endothelial Cells during Hyperglycemic Condition

Taïlé

Arcambal

Clerc³

et al. 2020

Antioxidants

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Blood-brain barrier endothelial cells are the main targets of diabetes-related hyperglycemia that alters endothelial functions and brain homeostasis. Hyperglycemia-mediated oxidative stress may play a causal role. This study evaluated the protective effects of characterized polyphenol-rich medicinal plant extracts on redox, inflammatory and vasoactive markers on murine bEnd3 cerebral endothelial cells exposed to high glucose concentration. The results show that hyperglycemic condition promoted oxidative stress through increased reactive oxygen species (ROS) levels, deregulated antioxidant superoxide dismutase (SOD) activity, and altered expression of genes encoding Cu/ZnSOD, MnSOD, catalase, glutathione peroxidase (GPx), heme oxygenase-1 (HO-1), NADPH oxidase 4 (Nox4), and nuclear factor erythroid 2-related factor 2 (Nrf2) redox factors. Cell preconditioning with inhibitors of signaling pathways highlights a causal role of nuclear factor kappa B (NFκB), while a protective action of AMP-activated protein kinase (AMPK) on redox changes. The hyperglycemic condition induced a pro-inflammatory response by elevating NFκB gene expression and interleukin-6 (IL-6) secretion, and deregulated the production of endothelin-1 (ET-1), endothelial nitric oxide synthase (eNOS), and nitric oxide (NO) vasoactive markers. Importantly, polyphenolic extracts from Antirhea borbonica, Ayapana triplinervis, Dodonaea viscosa, and Terminalia bentzoe French medicinal plants, counteracted high glucose deleterious effects by exhibiting antioxidant and anti-inflammatory properties. In an innovative way, quercetin, caffeic, chlorogenic and gallic acids identified as predominant plant polyphenols, and six related circulating metabolites were found to exert similar benefits. Collectively, these findings demonstrate polyphenol protective action on cerebral endothelial cells during hyperglycemic condition.

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Camphor elicits up-regulation of hepatic and pulmonary pro-inflammatory cytokines and chemokines via activation of NF-kB in rats

Cited by 23 publications

References 55 publications

Hepatic oxidative stress, up-regulation of pro-inflammatory cytokines, apoptotic and oncogenic markers following 2-methoxyethanol administrations in rats

Hepatic oxidative stress, up-regulation of pro-inflammatory cytokines, apoptotic and oncogenic markers following 2-methoxyethanol administrations in rats

Salvia miltiorrhiza-Derived Sal-miR-58 Induces Autophagy and Attenuates Inflammation in Vascular Smooth Muscle Cells

Medicinal Plant Polyphenols Attenuate Oxidative Stress and Improve Inflammatory and Vasoactive Markers in Cerebral Endothelial Cells during Hyperglycemic Condition

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