Camphor Intoxication Treated by Lipid Dialysis

Ginn, H. Earl; Anderson, Karl E.; Mercier, Robert K.; Stevens, Timothy W.; Matter, Billy J.

doi:10.1001/jama.1968.03140030062018

Cited by 22 publications

(11 citation statements)

References 1 publication

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“…The other substance found in the blood was camphor that is a highly liposoluble substance with mild topical antiseptic and anesthetic effects . When administered orally, it is readily absorbed by mucous membranes with measurable levels (0.5 to 1.0 gram) 15 min after ingestion in 3 year‐old children and 12 g in adult pregnant woman .…”

Section: Discussionmentioning

confidence: 99%

Fatal Ingestion of Chlumsky Disinfectant Solution

Handlos

Uvíra

Marecová

et al. 2017

Journal of Forensic Sciences

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A 32-year-old pregnant woman in the 25th week of pregnancy underwent oral glucose tolerance screening at the diabetologist's. Later that day, she was found dead in her apartment possibly poisoned with Chlumsky disinfectant solution (solutio phenoli camphorata). An autopsy revealed chemical burns in the digestive system. The lungs and the brain showed signs of severe edema. The blood of the woman and fetus was analyzed using gas chromatography with mass spectrometry and revealed phenol, its metabolites (phenyl glucuronide and phenyl sulfate) and camphor. No ethanol was found in the blood samples. Both phenol and camphor are contained in Chlumsky disinfectant solution, which is used for disinfecting surgical equipment in healthcare facilities. Further investigation revealed that the deceased woman had been accidentally administered a disinfectant instead of a glucose solution by the nurse, which resulted in acute intoxication followed by the death of the pregnant woman and the fetus.

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Section: Discussionmentioning

confidence: 99%

Fatal Ingestion of Chlumsky Disinfectant Solution

Handlos

Uvíra

Marecová

et al. 2017

Journal of Forensic Sciences

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“…25 Initially, local irritation of the GI tract occurred following ingestion, manifest by pain in the mouth and throat, nausea, vomiting, and a nonspecifi c feeling of warmth. 28 Life -threatening effects include status epilepticus, coma, apnea, and pulmonary aspiration. Other clinical features of camphor intoxication include headache, lightheadedness, anxiety, agitation, confusion, hallucinations, hyperrefl exia, and myoclonus.…”

Section: Acute Effectsmentioning

confidence: 99%

Camphor (Cinnamomum camphoraT. Nees & Eberm.)

Barceloux

2008

Medical Toxicology of Natural Substances

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“…Among those with dose-effect information was a level 4 retrospective review (41), a brief level 4 composite case series (8), and 23 individual cases reported in 16 level 4 articles (7,9,10,12,14,25,26,48,(58)(59)(60)(61)(62)(63)(64)(65). The smallest dose of camphorated oil associated with toxicity was 0.5 teaspoonful (500 mg or 18.5 mg/kg), which caused mild toxicity in a 6-yearold boy with mumps (48).…”

Section: Camphorated Oilmentioning

confidence: 99%