Camptocormia as a form of dystonia in Parkinson's disease

Sławek, Jarosław; Derejko, Mirosława; Lass, Piotr

doi:10.1046/j.1468-1331.2003.00503_1.x

Cited by 44 publications

(31 citation statements)

References 14 publications

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“…Although the MADRS is not usually used for screening purposes, one group 79,80 reported on its use in screening for dPD. Cutoff scores in PD of 14/15 for screening (high sensitivity and high NPV) and 17/18 (high specificity and high PPV) for diagnostic purposes have been validated in PD against a diagnosis of major depressive disorder.…”

Section: Depression In Pdmentioning

confidence: 99%

Depression rating scales in Parkinson's disease: Critique and recommendations

Schrag¹,

Barone²,

Brown³

et al. 2007

Movement Disorders

592

348

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Depression is a common comorbid condition in Parkinson's disease (PD) and a major contributor to poor quality of life and disability. However, depression can be difficult to assess in patients with PD due to overlapping symptoms and difficulties in the assessment of depression in cognitively impaired patients. As several rating scales have been used to assess depression in PD (dPD), the Movement Disorder Society commissioned a task force to assess their clinimetric properties and make clinical recommendations regarding their use. A systematic literature review was conducted to explore the use of depression scales in PD and determine which scales should be selected for this review. The scales reviewed were the Beck Depression Inventory (BDI), Hamilton Depression Scale (Ham-D), Hospital Anxiety and Depression Scale (HADS), Zung Self-Rating Depression Scale (SDS), Geriatric Depression Scale (GDS), Montgomery-Asberg Depression Rating Scale (MADRS), Unified Parkinson's Disease Rating Scale (UPDRS) Part I, Cornell Scale for the Assessment of Depression in Dementia (CSDD), and the Center for Epidemiologic Studies Depression Scale (CES-D). Seven clinical researchers with clinical and research experience in the assessment of dPD were assigned to review the scales using a structured format. The most appropriate scale is dependent on the clinical or research goal. However, observer-rated scales are preferred if the study or clinical situation permits. For screening purposes, the HAM-D, BDI, HADS, MADRS, and GDS are valid in dPD. The CES-D and CSDD are alternative instruments that need validation in dPD. For measurement of severity of depressive symptoms, the Ham-D, MADRS, BDI, and SDS scales are recommended. Further studies are needed to validate the CSDD, which could be particularly useful for the assessment of severity of dPD in patients with comorbid dementia. To account for overlapping motor and nonmotor symptoms of depression, adjusted instrument cutoff scores may be needed for dPD, and scales to assess severity of motor symptoms (e.g., UPDRS) should also be included to help adjust for confounding factors. The HADS and the GDS include limited motor symptom assessment and may, therefore, be most useful in rating depression severity across a range of PD severity; however, these scales appear insensitive in severe depression. The complex and time-consuming task of developing a new scale to measure depression specifically for patients with PD is currently not warranted.

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Section: Depression In Pdmentioning

confidence: 99%

Depression rating scales in Parkinson's disease: Critique and recommendations

Schrag¹,

Barone²,

Brown³

et al. 2007

Movement Disorders

592

348

View full text Add to dashboard Cite

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“…Axial or action dystonia is considered to be a possible etiology for CC in PD [34] . For instance, Sławek et al [34] describe a 49-year-old woman with PD who showed a painful trunk flexion/CC which improved markedly after unilateral pallidotomy.…”

Section: Axial or Action Dystonia As A Cause Of CC And Dhs In Pdmentioning

confidence: 99%

“…For instance, Sławek et al [34] describe a 49-year-old woman with PD who showed a painful trunk flexion/CC which improved markedly after unilateral pallidotomy. The only case-control study performed by Bloch et al [21] suggests an axial or action dystonia of the trunk with excessive activation of the abdominal-wall muscles, supported by the observations that CC worsens during walking and standing, and that fatigue worsens CC [7,14] .…”

Section: Axial or Action Dystonia As A Cause Of CC And Dhs In Pdmentioning

confidence: 99%

Camptocormia in Parkinson’s Disease: A Review of the Literature

Ponfick¹,

Gdynia²,

Ludolph³

et al. 2011

Neurodegener Dis

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Camptocormia (CC) is defined as a trunkal flexion which worsens while standing, sitting and walking and disappears in the supine position. CC is a well-known clinical phenomenon in patients with generalized neuromuscular disorders like polymyositis, myasthenia gravis or motor neuron diseases, and it is also described in the context of movement disorders like Parkinson’s disease (PD) or multiple system atrophy. In association with PD, CC seems to be a rare symptom which occurs preferentially in late stages of the disease. Currently, there are 3 main hypotheses on the pathogenesis of CC in PD, i.e. a focal myopathy of the trunk muscles, axial dystonia and a drug-induced etiology. This review gives a synopsis and critical acclaim of these 3 etiologies and refers to the current study data and possible treatment strategies.

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“…Camptocormia may represent a form of dystonia in patients with PD, but this concept is not universally accepted (11,22). Deep brain stimulation for patients with PD has been widely accepted as an alternative for these patients when medications are no longer effective or side effects are intolerable.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, Nandi et al reported a case of a young man without PD undergoing bilateral globus pallidus internus (GPi) DBS for disabling camptocormia secondary to neuroleptic medication side effects (13). The report by Slawek and colleagues was that of a 49-year-old woman with PD and camptocormia, who underwent unilateral pallidotomy that resulted in significant bilateral symptomatic improvement in her camptocormia (22). Micheli et al targeted the globus pallidus internus bilaterally in their patient with PD and camptocormia also resulting in near complete resolution in the patient's truncal flexion deformity at 14 months postoperatively (11).…”

mentioning

confidence: 99%

Long-term benefit of bilateral subthalamic deep brain stimulation on camptocormia in parkinson’s disease

Lyons¹,

Boucher²,

Patel³

et al. 2010

Turkish Neurosurgery

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We report the case of a 63-year-old female with a long history of severe Parkinson's disease (PD) and subsequent onset of debilitating camptocormia who underwent successful bilateral subthalamic nucleus deep brain stimulation surgery (STN DBS). The literature and previous reports are reviewed. The patient history and details of the surgical procedure are reported including the implantable pulse generator (IPG) settings and response to stimulation. The results of her PD symptom and camptocormia improvements are discussed. Five year postoperatively, the patient has enjoyed good results for both her PD symptoms as well as significant and sustained improvement in her thoracolumbar flexion deformity. She remains on minimal medications and no longer requires any assistive devices for ambulation. Comparison and contrast of the current world literature on DBS for camptocormia is reviewed. We discuss the current targets used for DBS in the setting of camptocormia in the cases reported, both PD associated and not associated. The optimal target has yet to be defined and further work on appropriate patient selection is needed. ÖZUzun süredir şiddetli Parkinson hastalığı (PH) ve yakın zamanda maluliyete neden olan kamptokormisi olan ve bilateral subtalamik nükleus derin beyin stimülasyon cerrahisinin (STN DBS) başarıyla yapıldığı 63 yaşında bir kadın hastayı sunuyoruz. Literatür ve önceki raporlar gözden geçirilmektedir. Hasta öyküsü ve implante edilen puls jeneratörü (IPG) ayarları ve stimülasyona cevap dahil olmak üzere cerrahi işlem ayrıntıları bildirilmiştir. PD belirtilerinin sonuçları ve kamptokormideki gelişmeler anlatılmaktadır. Ameliyattan beş yıl sonra hasta halen PD belirtileri açısından iyi sonuçlar ve torakolumbar fleksiyon deformitesinde önemli ve uzun süreli iyileşme mevcuttu. Hasta çok az sayıda ilaç kullanmakta ve artık ambulasyon için yardımcı cihazlara gereksinim duymamaktadır. Kamptokormi için DBS konusunda mevcut dünya literatürü bilgileri karşılaştırılmış ve değerlendirilmektedir. Bildirilen vakalarda PD ile ilişkili olsun veya olmasın kamptokormi durumunda DBS için kullanılan mevcut hedefleri gözden geçiriyoruz. Optimum hedefin halen tanımlanması gerekmektedir ve uygun hasta seçimi açısından hâlâ yapılması gerekenler vardır.

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Camptocormia as a form of dystonia in Parkinson's disease

Cited by 44 publications

References 14 publications

Depression rating scales in Parkinson's disease: Critique and recommendations

Depression rating scales in Parkinson's disease: Critique and recommendations

Camptocormia in Parkinson’s Disease: A Review of the Literature

Long-term benefit of bilateral subthalamic deep brain stimulation on camptocormia in parkinson’s disease

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