2021
DOI: 10.1097/jcp.0000000000001442
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Camptocormia Secondary to Antipsychotic-Associated Dystonia of the Rectus Abdominis Muscles Detected by Abdominal Computed Tomography

Abstract: However, dopamine supersensitivity can be permanent as seen in tardive dyskinesia. Antipsychotic dose and D2 receptor occupancy follow a hyperbolic association. A similar hyperbolic relationship is seen with antipsychotic dose and therapeutic effects. 12,13 Applying this to perphenazine helps us understand that a maximum response can be expected at lower doses and less robust response at higher doses since most of the D2 receptors are already occupied. Similarly, in reverse, maximal chances of withdrawal are a… Show more

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