Camptothecin and its analogues: a review on their chemotherapeutic potential

Sriram, Dharmarajan; Yogeeswari, P; Rathinasabapathy, Thirumurugan; Bal, Tanushree Ratan

doi:10.1080/14786410412331299005

Cited by 136 publications

(86 citation statements)

References 74 publications

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“…It is usually classified in the tupelo family Nyssaceae, which includes two species: Camptotheca acuminata Decne and Camptotheca lowreyana. Camptotheca acuminata has been used as traditionally Chinese medicine for centuries, all parts of this fast growing tree contain the secondary metabolite, camptothecin (CPT, an indole alkaloid), which is an effective drug against several types of cancer [2][3][4] . It is reported that CPT can induce apoptosis or death in various cancer cells by interfering with the topoisomerase I, an essential enzyme in the DNA replication process [5][6][7][8] .…”

Section: Introductionmentioning

confidence: 99%

Characterization and antitumor activity of camptothecin from endophytic fungus Fusarium solani isolated from Camptotheca acuminate

Ran

Zhang

et al. 2017

Afr H. Sci.

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Background: Camptothecin (CPT) is a potent drug against cancers, originally from plants. The endophytic fungi could produce the secondary metabolite same as the host and is used as medicine. Objectives:The aim of this paper was to investigate an endophytic fungal CPT with anti-neoplastic activity. Methods: Endophytic fungi were isolated from Camptotheca acuminata in China. CPT from strain S-019 was characterized by TLC, HPLC and EI-MS analysis. Anti-tumor activity of fungal CPT was detected by MTT and fluorescent dye methods using Vero and PC-3 cells. Results: A total of 94 endophytic fungi strains were isolated from tissues of C. acuminata and 16 fungi strains displayed cytotoxic activity on Vero or PC3 cells. Of which, the fungal strain S-019, classified as Fusarium solani, displayed impressive cytotoxic activity on cancer cells and was found to produce CPT by analysis of TLC, HPLC and EI-MS methods. Bioassay studies confirmed that the fungi CPT had potent cytotoxicity on Vero cells and induced apoptosis of Vero cells. Conclusion:The endophytic fungi from camptotheca trees are a reliable source for natural anticancer compounds. The endophytic fungi could produce CPT same as plant. The fungal CPT exhibited effective activity at inhibiting cell growth and inducing apoptosis on Vero cells.

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Section: Introductionmentioning

confidence: 99%

Characterization and antitumor activity of camptothecin from endophytic fungus Fusarium solani isolated from Camptotheca acuminate

Ran

Zhang

et al. 2017

Afr H. Sci.

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“…Many of these novel anticancer agents have a history of use in traditional medicine, notably in TCM. The most prominent among them are: i) camptothecin, isolated from the Chinese 'happy tree' Camptotheca acuminata (19); ii) podophyllotoxin from Podophyllum peltatum, originally used by Native Americans but also found in large amounts in Podophyllum emodi var. Chinense (20); and iii) paclitaxel initially obtained from Taxus brevifolia and present in high quantities in Taxus chinensis (21).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of aqueous extracts of Taraxacum officinale on growth and invasion of breast and prostate cancer cells

Sigstedt

Hooten²,

Callewaert³

et al. 2008

Int J Oncol

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Abstract. Ethnotraditional use of plant-derived natural products plays a significant role in the discovery and development of potential medicinal agents. Plants of the genus Taraxacum, commonly known as dandelions, have a history of use in Chinese, Arabian and Native American traditional medicine, to treat a variety of diseases including cancer. To date, however, very few studies have been reported on the anti-carcinogenic activity of Taraxacum officinale (TO). In the present study, three aqueous extracts were prepared from the mature leaves, flowers and roots, and investigated on tumor progression related processes such as proliferation and invasion. Our results show that the crude extract of dandelion leaf (DLE) decreased the growth of MCF-7/AZ breast cancer cells in an ERK-dependent manner, whereas the aqueous extracts of dandelion flower (DFE) and root (DRE) had no effect on the growth of either cell line. Furthermore, DRE was found to block invasion of MCF-7/ AZ breast cancer cells while DLE blocked the invasion of LNCaP prostate cancer cells, into collagen type I. Inhibition of invasion was further evidenced by decreased phosphorylation levels of FAK and src as well as reduced activities of matrix metalloproteinases, MMP-2 and MMP-9. This study provides new scientific data on TO and suggests that TO extracts or individual components present in the extracts may be of value as novel anti-cancer agents. IntroductionPlants of the genus Taraxacum, also known as dandelions, are members of the Asteraceae family. These perennial plants are widespread throughout the warmer temperate zones of the Northern Hemisphere and have been used for centuries as a remedy for various ailments by several societies. Dandelions play a pivotal role in traditional Chinese medicine (TCM) and are frequently used for treatment of breast, uterine and lung tumors as well as hepatitis and digestive diseases (1,2), while Native Americans use dandelion roots and herbs to treat kidney disease, dyspepsia and heartburn. In traditional Arabian medicine, dandelions have been applied to remedy liver and spleen disorders (3), whereas European herbalists authorize the use of dandelions for fever, boils, eye problems, diabetes and diarrhea (4).The variety of health benefits associated with the use of dandelions has been attributed to specific Taraxacum species as extracts of the whole plants or specific plant parts. Anticarcinogenic activities have been reported for the aqueous root extract of Taraxacum japonicum on mouse skin tumors (5). Further study revealed that taraxasterol and taraxerol, triterpenoids isolated from T. japonicum, were responsible for the observed effect on mouse skin tumors and that taraxasterol inhibited spontaneous mammary carcinogenesis, after oral administration (6). Taraxinic acid, isolated from Taraxacum coreanum showed potent antiproliferative activity against HL-60 cells (7) and the ethanolic extracts of the Chinese dandelion root (Taraxacum mongolicum) inhibited the growth of B16 2F2 mouse melanoma cells (8). Antitumor...

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“…Among others, two water soluble analogues of the alkaloid camptothecin are increasingly in clinical use [167][168][169][170]. Like many other pharmaceutical drug candidates, camptothecins have suboptimal properties mostly caused by their low water solubility and this resulted in their failure in early clinical trials [167].…”

Section: Methodsmentioning

confidence: 99%

Polyester Dendrimers: Smart Carriers for Drug Delivery

Twibanire

Grindley

2014

Polymers

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Polyester dendrimers have been shown to be outstanding candidates for biomedical applications. Compared to traditional polymeric drug vehicles, these biodegradable dendrimers show excellent advantages especially as drug delivery systems because they are non-toxic. Here, advances on polyester dendrimers as smart carriers for drug delivery applications have been surveyed. Both covalent and non-covalent incorporation of drugs are discussed.

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Camptothecin and its analogues: a review on their chemotherapeutic potential

Cited by 136 publications

References 74 publications

Characterization and antitumor activity of camptothecin from endophytic fungus <i>Fusarium solani</i> isolated from <i>Camptotheca acuminate</i>

Characterization and antitumor activity of camptothecin from endophytic fungus <i>Fusarium solani</i> isolated from <i>Camptotheca acuminate</i>

Evaluation of aqueous extracts of Taraxacum officinale on growth and invasion of breast and prostate cancer cells

Polyester Dendrimers: Smart Carriers for Drug Delivery

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