Camptothecin-Carrying Cuco2s4 Nanoparticles: Sustained Drug Release And Anticancer Activity

Abstract

Nanocarriers of anticancer drugs are delicately designed with precision addition at every attempt. In this paper, we report CuCo2S4 nanoparticles that show light-absorption in the NIR-II wavelength range and possess magnetic characteristics. The synthesized nanoparticles are characterized employing XRD, SEM, DLS, TGA, and XPS methods. The nanoparticles form a composite with biocompatible polymeric β-cyclodextrin. The nanoparticles possess a band gap energy of 2.25 eV. The magnetic property arises due to the cobalt-incorporation in the nanoparticles. The anticancer drug, camptothecin, is loaded in the nanocarrier with an 89% adsorption efficiency. The in vitro release of the drug occurs in a sustained fashion. Further, the in vitro anticancer potential of the nanocarrier is examined on breast cancer (MDA=MB-231) cell lines and the activities of the free- and the drug-loaded nanocarrier are compared. The cobalt-containing copper sulfide nanoparticle-poly-β-cyclodextrin composite works as a promising nanocarrier of camptothecin.

A new biosynthesis of CuCo2S4 nanoparticles as a high‐performance supercapacitor electrode and excellent non‐enzymatic hydrazine sensor

“…In fact, nanomaterials have gained interest for their promising energy applications, such as electrochemical energy storage [3,4] and hydrogen storage [5]. Metal sulphides have been recently used in various application fields such as photocatalyst [6,7], catalyst [8], photovoltaic [9], anti-bacterial activity [10,11], energy storage devices [12,13,14] and non-enzymatic sensors [15,16,17].…”