Camptothecin-catalyzed phospholipid hydrolysis in liposomes

Nanocomposite liposomes containing quantum dots and anticancer drugs for bioimaging and therapeutic delivery: a comparison of cationic, PEGylated and deformable liposomes

“…The higher solubilization effect of QD-loaded liposomes in comparison to formulations without QDs resulted in a faster release rate [13]. Although liposomes retarded camptothecin release to a certain level, an earlier study [27] reported that camptothecin can hydrolyze liposomal bilayers to enhance membrane leakage and accelerate drug release. This effect may be attenuated by adding stearylamine to liposomes, since this dispersion demonstrated the lowest camptothecin release.…”

Treatment of Rat Brain Tumors Using Sustained-Release of Camptothecin from Poly(lactic-co-glycolic acid) Microspheres in a Thermoreversible Hydrogel

“…[17][18][19][20][21] At the same time, many new drug delivery systems were developed, such as liposomes, polymer micelles, and polymer hybrids. [22][23][24][25][26][27][28][29][30] Here, we examined the use of poly(lactic-co-glycolic acid) (PLGA) microspheres embedded in a thermoreversible gelation polymer (TGP) as a system for the sustained delivery of camptothecin to brain tumors. PLGA is a biodegradable polymer that is metabolized in the body into H 2 O and CO 2 .…”

Sequential acid/reduction response of triblock copolymeric nanomicelles to release camptothecin and toll-like receptor 7/8 agonist for orchestrated chemoimmunotherapy

“…Although CPT has an excellent curative effect, its clinical application is limited due to its low water solubility and high toxicity [ 21 ]. Traditional nano-formulations can effectively improve the in vivo pharmacokinetics of CPT, but the physical encapsulation of CPT will still cause damage to the body due to quick leakage in systemic circulation [ 22 ]. Covalent ligation to polymeric carriers might offer chemically better-defined alternatives to physical encapsulation technology.…”