Camptothecin-Discovery, Clinical Perspectives and Biotechnology

doi:10.4172/2329-6836.1000175

Cited by 7 publications

(1 citation statement)

References 84 publications

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“…The semi-synthetic derivatives of CPT, topotecan and irinotecan have been employed worldwide as clinical antitumor agents against lungs, cervix, ovaries, and colon cancers [3][4][5]. The annual CPT production by plants globally is only 600 kg; thus, it cannot meet the world market's estimated demand of about 3000 kg per year [6]. Despite the high demand for CPT for use in antitumor drugs, CPT has been extracted mainly from two arboreous plants, Camptotheca acuminata and Nothapodytes foetida (Olacaceae), which have a slow growth rate and low plant productivity and require wide cultivation area and high photosynthetic photon flux density (PPFD) [2,7].…”

Section: Introductionmentioning

confidence: 99%

Optimal harvest-time to maximize the annual camptothecin production by Ophiorrhiza pumila in a plant factory with artificial light

et al. 2022

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Ophiorrhiza pumila is a medicinal plant that grows in subtropical forests and produces camptothecin (CPT). To determine an optimal harvest time of O. pumila in a plant factory with artificial light (PFAL), we investigated the CPT distribution in each organ and at the developmental stage and estimated the annual CPT production. For this study, the O. pumila plants were grown in controlled environments (16 h light period, photosynthetic photon flux density of 100 μmol m−2 s−1 under white light-emitting diode lamps, air temperature of 28 °C, relative humidity of 80%, and CO2 concentration of 1000 μmol mol−1). First, the stem, root, and seed pod had higher CPT contents than the leaves, flower, and ovary. The optimal harvest time of O. pumila in a PFAL was 63 days after transplanting (DAT), because the CPT content in the whole organs was the highest at the seed-ripening stage. Second, based on these results, the estimated annual CPT production of O. pumila cultivated in a PFAL was 380 mg m−2 y−1 (63 DAT). This value was 4.3 times greater than the annual CPT production by Camptotheca acuminata in a greenhouse. We concluded that the CPT production by O. pumila in a PFAL throughout the year has many advantages, although the demand for electrical energy was high compared to that of Camptotheca acuminata in a greenhouse.

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Section: Introductionmentioning

confidence: 99%

Optimal harvest-time to maximize the annual camptothecin production by Ophiorrhiza pumila in a plant factory with artificial light

et al. 2022

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Leaving No Stone Unturned: Unraveling the Path to Maximizing the Potential for Discovery of Novel Antineoplastics

Karimi,

Umoru,

El Rahi

2023

Environmental Oncology

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Micropropagation and Conservation of Selected Endangered Anticancer Medicinal Plants from the Western Ghats of India

Swamy

Paramashivaiah²,

Hiremath³

et al. 2018

Anticancer Plants: Natural Products and Biotechnological Implements

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Globally, cancer is a constant battle which severely affects the human population. The major limitations of the anticancer drugs are the deleterious side effects on the quality of life. Plants play a vital role in curing many diseases with minimal or no side effects. Phytocompounds derived from various medicinal plants serve as the best source of drugs to treat cancer. The global demand for phytomedicines is mostly reached by the medicinal herbs from the tropical nations of the world even though many plant species are threatened with extinction. India is one of the mega diverse countries of the world due to its ecological habitats, latitudinal variation, and diverse climatic range. Western Ghats of India is one of the most important depositories of endemic herbs. It is found along the stretch of south western part of India and constitutes rain forest with more than 4000 diverse medicinal plant species. In recent times, many of these therapeutically valued herbs have become endangered and are being included under the red-listed plant category in this region. Due to a sharp rise in the demand for plantbased products, this rich collection is diminishing at an alarming rate that eventually triggered dangerous to biodiversity. Thus, conservation of the endangered medicinal plants has become a matter of importance. The conservation by using only in situ approaches may not be sufficient enough to safeguard such a huge bio-resource of endangered medicinal plants. Hence, the use of biotechnological methods would be vital to complement the ex vitro protection programs and help to reestablish endangered plant species. In this backdrop, the key tools of biotechnology that could assist plant conservation were developed in terms of in vitro regeneration, seed banking, DNA storage, pollen storage, germplasm storage, gene bank (field gene banking), tissue bank, and cryopreservation. In this chapter, an attempt has been made to critically review major endangered medicinal plants that possess anticancer compounds and their conservation aspects by integrating various biotechnological tools

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Camptothecin-Discovery, Clinical Perspectives and Biotechnology

Cited by 7 publications

References 84 publications

Optimal harvest-time to maximize the annual camptothecin production by Ophiorrhiza pumila in a plant factory with artificial light

Optimal harvest-time to maximize the annual camptothecin production by Ophiorrhiza pumila in a plant factory with artificial light

Leaving No Stone Unturned: Unraveling the Path to Maximizing the Potential for Discovery of Novel Antineoplastics

Micropropagation and Conservation of Selected Endangered Anticancer Medicinal Plants from the Western Ghats of India

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