Camptothecin-incorporating N-phthaloylchitosan-g-mPEG self-assembly micellar system: Effect of degree of deacetylation

Opanasopit, Praneet; Ngawhirunpat, Tanasait; Rojanarata, Theerasak; Choochottiros, Chantiga; Chirachanchai, Suwabun

doi:10.1016/j.colsurfb.2007.06.001

Cited by 45 publications

(22 citation statements)

References 30 publications

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“…Furthermore, these CAC values are lower than those of other acyl chitosan derivatives previously reported e.g. N-phthaloyl chitosan (28 g/ml) [34], linolenic acid modified chitosan (50 g/ml) [35], and deoxycholic acid modified chitosan (17-41 g/ml) [36,37]. The lower CAC values of chitosan copolymers indicate the finite amount of the chitosan derivatives to form self-aggregates a condition which will probably maintain the stability of ATV polymeric micelles in highly diluted conditions permitting safe drug delivery to the target area.…”

Section: Critical Association Concentration (Cac)contrasting

confidence: 54%

Anticancer effect of atorvastatin nanostructured polymeric micelles based on stearyl-grafted chitosan

Mekhail

Kamel

Awad

et al. 2012

International Journal of Biological Macromolecules

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Section: Critical Association Concentration (Cac)contrasting

confidence: 54%

Anticancer effect of atorvastatin nanostructured polymeric micelles based on stearyl-grafted chitosan

Mekhail

Kamel

Awad

et al. 2012

International Journal of Biological Macromolecules

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“…Such polymeric micelles have been extensively researched for drug encapsulation, enhanced tumor targeting and longer in vivo circulation to aid an improved delivery system. Various approaches have been utilized to prepare polymeric micelles of desired properties using block copolymer, their lipid [ 111 ] or cyclodextrin [ 112 ] derivatives, diblock copolymers [ 113 ], triblock copolymers [ 114 ], pluronic polymer [ 115 ] and graft polymers [ 116 ].…”

Section: Micellar Delivery Systemsmentioning

confidence: 99%

Pharmaceutical Nanotechnology: Overcoming Drug Delivery Challenges in Contemporary Medicine

et al. 2014

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Drug discovery process has been in forefront utilizing recent advances in molecular biology, -together with medicinal chemistry, protein structure based screening, and computational analysis, as part of rational approach to discovering drug molecules that will address unmet clinical needs. For example, proteins identifi ed from structural biology platform can serve as targets for discovering new drug molecules. The discovery of antisense oligonucleotides (ASN), plasmid DNA (pDNA), peptides and protein therapeutics has also shown a greater potential in treating several complex diseases. A recent development in drug discovery is RNA interference (RNAi) which uses small stretches of double stranded RNA with 21-23 nucleotides in length, to inhibit the expression of a gene of interest bearing its complementary sequence [ 1 ]. Small interfering RNA (siRNA) can induce RNAi in human cells. This RNAi technology has many advantages over other posttranscriptional gene silencing methods, such as gene knockouts and antisense technologies [ 2 ]. In addition, only a few molecules of siRNA need to enter a cell to inactivate a gene at almost any stage of development. MicroRNA (miRNA), advancement from siRNA, is a new class of drugs still in the investigative stage based on nucleic acid chemistry. miRNA with 19-25 nucleotides in length, interfere pathways that involve in disease process [ 3 ]. In general, all these recent drugs have shown a great potential in the clinical management of several complex diseases like cancer, metabolic diseases, auto-immune diseases, cardiovascular diseases, eye diseases, neurodegenerative disorders and other illness [ 1 ].

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“…Therefore, poly (ethylene glycol) is widely used as a pharmacological polymer with high hydrophilicity, biocompatibility and biodegradability. In recent years, derivative poly (ethylene glycol)-g-derivative chitosan to obtain nanoparticles has been studied by many researchers (Ouchi et al, 1998;Jung et al, 2006) (Park et al, 2008) (Yang et al, 2008b) (Opanasopit et al, 2007). The grafted poly (ethylene glycol) methyl ether onto N-Phthaloyl chitosan chains, aggregated to obtain sphere-like nanoparticles (an et al, 2004).…”

Section: Linear Hydrophobic Moleculesmentioning

confidence: 99%

“…A poorly water-soluble anticancer drug, methotrexate was physically entrapped inside the nanoparticles. Other group synthesized amphiphilic grafted copolymers, N-phthaloyl chitosan-grafted poly (ethylene glycol) methyl ether (Opanasopit et al, 2007). These copolymers could form micelle-like nanoparticles.…”

Section: Linear Hydrophobic Moleculesmentioning

confidence: 99%

Nanoparticles Based on Modified Polysaccharides

Namazi¹,

Fathi²,

Heydari³

2012

The Delivery of Nanoparticles

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Camptothecin-incorporating N-phthaloylchitosan-g-mPEG self-assembly micellar system: Effect of degree of deacetylation

Cited by 45 publications

References 30 publications

Anticancer effect of atorvastatin nanostructured polymeric micelles based on stearyl-grafted chitosan

Anticancer effect of atorvastatin nanostructured polymeric micelles based on stearyl-grafted chitosan

Pharmaceutical Nanotechnology: Overcoming Drug Delivery Challenges in Contemporary Medicine

Nanoparticles Based on Modified Polysaccharides

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