Camptothecin loaded casein nanosystem for tuning the therapeutic efficacy against highly metastatic triple-negative breast cancer cells

Abstract

The heterogenic dilema of TNBC and the side effects of chemo drugs leads to the failure of successful therapy. Protein-based nanoplatforms have emerged as an important domain in protein-engineered biomedicine...

The Effect of A2 Milk on Gastrointestinal Symptoms in Comparison to A1/A2 Milk: A Single-center, Randomized, Double-blind, Cross-over Study

“…The beneficial action of casein protein is generally thought to be based on immune enhancement. Casein peptides are reported to act as enhancers of the immune system and induce death of malignant cells [ 1 ], and could be involved in the development of the mucosal immune system [ 36 ] and erythropoiesis [ 37 ] in mice. Casein also inhibited the azoxymethane-induced colon carcinogenesis in rats [ 38 ].…”

7-Amino-6H-anthra[9,1-cd] Isothiazol-6-one-Casein Nanosystem for Live Cell Staining and Augmenting Therapeutic Effectiveness in Triple Negative Breast Cancer

“…Casein nanosystems represent a fascinating and promising frontier in cancer therapy. These nanosystems are engineered using Casein, a protein found in milk, and they offer a versatile platform for delivering therapeutic agents to combat cancer. , By encapsulating drugs or other therapeutic molecules within these nanosystems, researchers are developing innovative ways to target and treat cancer cells with precision and efficacy. ,, The unique properties of the Casein nanosystem, such as biocompatibility and stability, make them an ideal option for drug delivery in cancer therapy. These proteins exist as colloids with a mass of 108 Da and a diameter of 200 nm.…”

“…10,11 By encapsulating drugs or other therapeutic molecules within these nanosystems, researchers are develop- ing innovative ways to target and treat cancer cells with precision and efficacy. 10,12,13 The unique properties of the Casein nanosystem, such as biocompatibility and stability, make them an ideal option for drug delivery in cancer therapy. These proteins exist as colloids with a mass of 108 Da and a diameter of 200 nm.…”