In order to meet the large demand of college students in mental health management, an interactive management system for college students' mental health based on mobile devices is proposed. The system is developed based on Android platform, and realizes data interaction and information management through network transmission and background. According to the common psychological problems of young college students, the system has designed different ways of interaction, which has improved the user experience. After testing and analysis, the system has the advantages of low hardware cost, high development efficiency and strong program expansibility, and has good use value and research significance.