Campylobacter infections, Guillain-Barré syndrome, and parenteral gangliosides

Recent Advances in the Understanding of the Immunological Basis of Peripheral Neuropathies

“…Reports of patients developing syndromes similar to MND 26 and GBS 15 , 27 while receiving these compounds raises the possibility that antibodies developing to components of Cronassial react with peripheral nerve gangliosides to produce these conditions. Although gangliosides are not usually immunogenic when given by injection, 28 they can induce an immune response when complexed to serum or tissue proteins 27 . Anti‐GM1 antibodies have been detected in patients developing GBS after parenteral ganglioside therapy 15 , 27 …”