Campylobacter jejuni-Associated Hemophagocytic Lymphohistiocytosis and Guillain-Barre Syndrome: A Case Report

Shi, Fang-e; Chen, Mei‐Fang; Li, Yongjie; Dong, Guiying; Zhu, Jihong

doi:10.3389/fmed.2022.895923

Cited by 3 publications

(3 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…HLH can present with a range of clinical and laboratory features, including fever, splenomegaly, neurological dysfunction, coagulopathy, liver dysfunction, cytopenias, hypertriglyceridemia, hyperferritinemia, hemophagocytosis, and reduced natural killer cell activity [ 9 ]. Only two cases of HLH caused by C. jejuni have been reported thus far [ 10 , 11 ].…”

Section: Discussionmentioning

confidence: 99%

Hemophagocytic lymphohistiocytosis and myopericarditis induced by campylobacter: a case report

Chang,

Kao

2024

BMC Infect Dis

View full text Add to dashboard Cite

Background Hemophagocytic lymphohistiocytosis (HLH) is a severe disorder characterized by excessive activation of the immune system, leading to hypercytokinemia and damage to multiple organs. We report a rare case of HLH with myopericarditis caused by Campylobacter infection. Case presentation A 28-year-old male patient with a history of hypertension without medicine control presented at the hospital after a four-day fever, decreasing urine amount, rashes on his trunk and limbs, and other symptoms. He was admitted with a provisional diagnosis of atypical infection and allergic skin rash related to diclofenac. However, his condition deteriorated, and he developed shock, tachycardia, chest distress, and bilateral pleural effusion after admission. Further investigations revealed cardiogenic shock related to myopericarditis, and he was transferred to the ICU. In addition, a stool PCR panel subsequently revealed a positive result for Campylobacter. On day 6, he was diagnosed with HLH. Under Clarithromycin and dexamethasone infusion, leukocytosis, anemia and thrombocytopenia with cardiogenic shock status improved. Then, he was later discharged in stable condition. Conclusions HLH and myopericarditis caused by Campylobacter are very rare. Early detection of Campylobacter-induced HLH and multiple organ failure, as well as prompt use of antibiotics and immunosuppressants, can be helpful for prognosis.

show abstract

Section: Discussionmentioning

confidence: 99%

Hemophagocytic lymphohistiocytosis and myopericarditis induced by campylobacter: a case report

Chang,

Kao

2024

BMC Infect Dis

View full text Add to dashboard Cite

show abstract

“…( 9) Only two cases of HLH caused by C. jejuni have been reported thus far. (10,11) To our knowledge, there have been no reported cases of Campylobacter causing both HLH and perimyocarditis. After ruling out other possible diagnoses, we concluded that Campylobacter infection triggered an autoimmune response, resulting in the development of both HLH and perimyocarditis in our patient.…”

Section: Discussionmentioning

confidence: 99%

Hemophagocytic Lymphohistiocytosis and Myopericarditis Induced by Campylobacter: A Case Report

Chang,

Kao

2023

Preprint

View full text Add to dashboard Cite

Background: Hemophagocytic lymphohistiocytosis (HLH) is a severe disorder characterized by excessive activation of the immune system, leading to hypercytokinemia and damage to multiple organs. We report a rare case of HLH with myopericarditis caused by Corynebacterium infection. Case presentation: A 28-year-old male patient with a history of hypertension without medicine control presented at the hospital after a four-day fever, decreasing urine amount, rashes on his trunk and limbs, and other symptoms. He was admitted with a provisional diagnosis of atypical infection and allergic skin rash related to diclofenac. However, his condition deteriorated, and he developed shock, tachycardia, chest distress, and bilateral pleural effusion after admission. Further investigations revealed cardiogenic shock related to myopericarditis, and he was transferred to the ICU. In addition, a stool PCR panel subsequently revealed a positive result for Campylobacter. On day 6, he was diagnosed with HLH. Under Klaricid and dexamethasone infusion, leukocytosis, anemia and thrombocytopenia with cardiogenic shock status improved. Then, he was later discharged in stable condition. Conclusions: HLH and myopericarditis caused by Campylobacter are very rare. Early detection of Campylobacter-induced HLH and multiple organ failure, as well as prompt use of antibiotics and immunosuppressants, can be helpful for prognosis.

show abstract

“…Over half of the GBS patients have IgG antiganglioside antibodies, ,,, and in many patients with AMAN and AMSAN, they are directed against GM1 and GD1a, but they can also be directed against other gangliosides. ,,, Up to 90% of the patients with MFS have antibodies against the GQ1b ganglioside, but antibodies against other gangliosides were also identified. ,,,− Cell culture studies and animal models of AMAN found that anti-GM1 antibodies block voltage-gated Na + channels, which are important for neuronal excitability and function, at the nodes of Ranvier by initiating a complement-mediated attack. , …”

Section: Molecular Mimicrymentioning

confidence: 99%

Campylobacter jejuni and Postinfectious Autoimmune Diseases: A Proof of Concept in Glycobiology

Stein

2022

ACS Infect. Dis.

View full text Add to dashboard Cite

Glycans, one of the most diverse groups of macromolecules, are ubiquitous constituents of all cells and have many critical functions, including the interaction between microbes and their hosts. One of the best model organisms to study the host−pathogen interaction, the gastrointestinal pathogen Campylobacter jejuni dedicates extensive resources to glycosylation and exhibits a diverse array of surface sugar-coated displays. The first bacterium where Nlinked glycosylation was described, C. jejuni can additionally modify proteins by O-linked glycosylation, has extracellular capsular polysaccharides that are important for virulence and represent the major determinant of the Penner serotyping scheme, and has outer membrane lipooligosaccharides that participate in processes such as colonization, survival, inflammation, and immune evasion. In addition to causing gastrointestinal disease and extraintestinal infections, C. jejuni was also linked to postinfectious autoimmune neuropathies, of which Guillain−Barrésyndrome (GBS) and Miller Fisher syndrome (MFS) are the most extensively characterized ones. These postinfectious autoimmune neuropathies occur when specific bacterial surface lipooligosaccharides mimic gangliosides in the host nervous system. C. jejuni provided the first proof of concept for the involvement of molecular mimicry in the pathogenesis of an autoimmune disease and, also, for the ability of a bacterial polymorphism to shape the clinical presentation of the postinfectious autoimmune neuropathy. The scientific journey that culminated with elucidating the mechanistic details of the C. jejuni−GBS link was the result of contributions from several fields, including microbiology, structural biology, glycobiology, genetics, and immunology and provides an inspiring and important example to interrogate other instances of molecular mimicry and their involvement in autoimmune disease.

show abstract

Campylobacter jejuni-Associated Hemophagocytic Lymphohistiocytosis and Guillain-Barre Syndrome: A Case Report

Cited by 3 publications

References 16 publications

Hemophagocytic lymphohistiocytosis and myopericarditis induced by campylobacter: a case report

Hemophagocytic lymphohistiocytosis and myopericarditis induced by campylobacter: a case report

Hemophagocytic Lymphohistiocytosis and Myopericarditis Induced by Campylobacter: A Case Report

Campylobacter jejuni and Postinfectious Autoimmune Diseases: A Proof of Concept in Glycobiology

Contact Info

Product

Resources

About