Campylobacter-Like Organisms in Patient With Ménétrier's Disease

Lepore, MichaelJ.; Smith, F; Bonanno, C.L.

doi:10.1016/s0140-6736(88)91251-2

Cited by 21 publications

(5 citation statements)

References 4 publications

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“…Recently, a new issue has been raised about the possible role of H. pylori (once called Campylobacter pylori) in PLE in childhood (11,16) and in Menetrier's disease in adulthood (10). In our patients, H. pylori did not seem to playa role.…”

Section: Discussionmentioning

confidence: 52%

Increased Tight Junction Width in Two Children with Ménétrier's Disease

Oderda,

Cinti,

Cangiotti

et al. 1990

J. pediatr. gastroenterol. nutr.

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SummaryProtein‐losing enteropathy (PLE) and edema are usually the most prominent clinical features in children with Ménétrier's disease. However, the changes in gastrointestinal mucosa that can cause PLE have not been described yet in children. We studied by electron microscopy the mucosa of the gastric fundus, which is the site where macroscopic changes are most prominent, in two children with Ménétrier's disease. We found that tight junction width was increased to 10.5 ± 0.94 nm (mean ± 1 SD) in one child and to 9.7 ± 0.7 in the other. Tight junction width returned to normal when PLE and edema subsided. These ultrastructural changes were similar to those described in adults with the disease, although the clinical course of Ménétrier's disease is very different in adults and in children. Both patients showed evidence of cytomegalovirus (CMV) infection, as indicated by increasing IgG antibodies against the virus or recovery of the virus in the urine. Although Helicobacter pylori was found in the antral mucosa of one patient, the clinical course of the disease was not related to this microorganism. We conclude that increased tight junction width plays a role in PLE seen in Ménétrier's disease in children and that CMV, rather than Helicobacter pylori, is associated with the disease.

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Section: Discussionmentioning

confidence: 52%

Increased Tight Junction Width in Two Children with Ménétrier's Disease

Oderda,

Cinti,

Cangiotti

et al. 1990

J. pediatr. gastroenterol. nutr.

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show abstract

“…Hypertrophic gastropathy has been associated previously with several infectious agents, including cytomegalovirus (CMV)(2,4,5,14,17,19,21), H. pylori (22,23), mycoplasma(24), herpes virus (19), and duodenal Giardia lamblia (25). Whether these agents are important etiologically is unclear.…”

Section: Discussionmentioning

confidence: 99%

Transient Hypertrophic Gastropathy

Jacobe,

Lam,

Elliott

1998

J. pediatr. gastroenterol. nutr.

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“…Although the etiology of childhood Ménétriér's disease is unclear, mainly allergic phenomena and infection have been implicated in the pathogenesis. Epidemiological evidence mainly supports cytomegalovirus (CMV), but other microorganisms including Helicobacter pylori and Mycoplasma pneumoniae have been implicated (11)(12)(13)(14)(15)(16)(17). This report describes a young child with Ménétriér's disease and provides additional evidence for an association between this disorder and CMV infection in childhood.…”

mentioning

confidence: 81%