Campylobacter pylori—Associated Gastritis and Peptic Ulcer Disease in Children

Evaluation of invasive and non-invasive methods for the diagnosis of Helicobacter pylori infection in symptomatic children and adolescents

“…The high sensitivity (93%) observed is consistent with other pediatric studies in older children and adolescents, 14,26,33,42,43 as was also the specificity (79%). 44,45 However, these results must be evaluated carefully, considering that the age of patients can influenced serology results, 28,29 because children's holdings of antibodies can be lower than for adults.…”

“…Histology showed high sensitivity (93%) as in other studies. 14,25 The false negative results are expected in biopsy-based method, because it is possible to obtain a fragment without Helicobacter pylori due to patchy distribution of bacteria in gastric mucosa. It has been described as a high specificity method, as we observed (100%).…”

“…4,[5][6][7][8] Nowadays, there is general consensus that Helicobacter pylori infection is the main etiological factor of primary gastritis in children and adults [9][10][11][12] and a significant correlation between Helicobacter pylori-associated gastritis and peptic ulcer disease has been found, especially with duodenal ulcer 10,13,14 . Gastric cancer 4,15 and lymphoproliferative gastric diseases, especially Malt lymphoma, also have been correlated with Helicobacter pylori infection.…”

Pyloric Narrowing with Increased Fibrous Tissue of the Mucosa in an Infant.

“…The mucosal histology is thought to be nonspecific, different from eosinophilic gastroenteritis and Helicobacter pylori-positive gastritis (Drumm et al 1987 ; Kilbridge et al 1988). It remains unclear whether or not the mucosal inflammation and fibrous change were secondary to frequent bilious vomiting.…”

Antral Brushings and Biopsies for GastricCampylobacter pylori: A Comparative Study of a Rapid Urease Test, Culture and Histology

“…Histologic studies: Two anrral biopsies were routinely processed a nd stained with hematoxylin and eosin. Hematoxylin and eosi n have been shown to be as effective as the G iemsa stain for detecting C pylori (32). One investigator reviewed each biopsy for the presence of C pylori and gastritis.…”